Patents by Inventor Johnson M. Liu

Johnson M. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloning of the human nuclear receptor co-repressor gene
    Patent number: 6949624
    Abstract: The present invention relates to the discovery of the human nuclear receptor co-repressor gene and the human nuclear receptor co-repressor protein, a molecule that recruits a complex of proteins that alters chromatin structure and mediates transcriptional repression. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: September 27, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Johnson M. Liu, Jianxiang Wang
  • Adeno-associated virus capable of expressing factor IX protein and cells comprising the same
    Patent number: 6670176
    Abstract: The subject invention concerns a recombinant adeno-associated virus vector characterized as being capable of delivering and expressing at least one mammalian gene into a genome of a mammalian host cell such that the expression of the gene is regulated in a tissue specific manner by cis-acting regulatory and promoter elements of the gene. A method of using this recombinant adeno-associated virus vector for therapeutic purposes is also provided.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: December 30, 2003
    Assignees: National Institutes of Health, University of Pittsburgh
    Inventors: Richard Jude Samulski, Christopher E. Walsh, Arthur W. Nienhuis, Johnson M. Liu, Jeffrey L. Miller
  • Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy
    Patent number: 6268213
    Abstract: The subject invention concerns a recombinant adeno-associated virus vector characterized as being capable of delivering and expressing at least one mammalian gene into a genome of a mammalian host cell such that the expression of the gene is regulated in a tissue specific manner by cis-acting regulatory and promoter elements of the gene. A method of using this recombinant adeno-associated virus vector for therapeutic purposes is also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 31, 2001
    Inventors: Richard Jude Samulski, Christopher E. Walsh, Arthur W. Nienhuis, Johnson M. Liu, Jeffrey L. Miller