Patents by Inventor Johnson Y. N. Lau

Johnson Y. N. Lau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis C virus protease-dependent chimeric pestivirus
    Patent number: 6326137
    Abstract: A chimeric bovine viral diarrhea virus (BVDV) that depends on a hepatitis C virus (HCV). The invention further relates to using the chimeric, infectious virus to screen for HCV NS3 inhibitor compounds in cell culture models or in animal models of viral infection.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: December 4, 2001
    Assignee: Schering Corporation
    Inventors: Zhi Hong, Vicki C. H. Lai, Johnson Y. N. Lau
  • Viral specific requirements for self-priming RNA replication of hepatitis C virus replicase
    Patent number: 6322966
    Abstract: The present invention relates to identification of the features of an RNA template that provide for efficient “copy-back” self-priming activity of hepatitis C virus replicase. This activity can be used to screen for anti-HCV replicase compounds, or to characterize the biological relevance of lead compounds that have already been identified. The specific features of the optimal RNA templates can be used for developing a system to characterize HCV NS5B polymerase mechanistically and kinetically, and for designing small RNA molecules to co-crystallize with HCV NS5B polymerase.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: November 27, 2001
    Inventors: Weidong Zhong, Zhi Hong, Johnson Y. N. Lau
  • De novo priming activity of hepatitis C virus replicase
    Patent number: 6297005
    Abstract: The present invention relates to identification of a novel, de novo priming activity of hepatitis C virus replicase. This activity can be used to screen for anti-HCV replicase compounds, or to characterize the biological relevance of lead compounds that have already been identified.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: October 2, 2001
    Assignee: Schering Corporation
    Inventors: Weidong Zhong, Zhi Hong, Annette Schettino Uss, Johnson Y. N. Lau