Patents by Inventor Joice Thomas

Joice Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of HPK1 and methods of use thereof
    Patent number: 12649751
    Abstract: Disclosed herein are compounds that are Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors having a structure according to Formula I, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
    Type: Grant
    Filed: July 6, 2023
    Date of Patent: June 9, 2026
    Assignee: Arcus Biosciences, Inc.
    Inventors: Joshua R. Corbin, Sandeep Dhanju, Corinne Nicole Foley, Jeremy Fournier, Padmanabha V. Kattamuri, Manmohan Reddy Leleti, Pradeep Nareddy, Jay Patrick Powers, Ehesan Ul Sharif, Joice Thomas
  • Opioid receptor antagonists
    Patent number: 12643907
    Abstract: The first selective SuFEx antagonists to ?-opioid receptors (MOR) were developed by functionalizing an opioid scaffold with an SO2—F warhead. Our model, based on a MOR structure with antagonist ?-FNA, indicates the naloxone carbonyl as an advantageous point for derivatization as it is chemically accessible and is not involved in interaction with receptors. Of the three accessible Tyr residues in MOR pocket, Tyr77, Tyr130 and Tyr150, Tyr150 in proximity to the carbonyl of the docked naloxone was selected as a target, which resulted in the development of highly potent antagonists.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: June 2, 2026
    Assignee: University of Southern California
    Inventors: Vsevolod Katritch, Valery V. Fokin, Saheem Zaidi, Joice Thomas
  • Piperidylurea compounds and methods of use thereof
    Patent number: 12630562
    Abstract: Disclosed herein are compounds having a structure according to Formula II, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
    Type: Grant
    Filed: August 5, 2025
    Date of Patent: May 19, 2026
    Assignee: Arcus Biosciences, Inc.
    Inventors: Joshua R. Corbin, Sandeep Dhanju, Corinne Nicole Foley, Jeremy Fournier, Padmanabha V. Kattamuri, Manjunath Lamani, Manmohan Reddy Leleti, Pradeep Nareddy, Ehesan Ul Sharif, Joice Thomas, Monika Yadav
  • PIPERIDYLUREA COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20260042777
    Abstract: Disclosed herein are compounds having a structure according to Formula II, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
    Type: Application
    Filed: August 5, 2025
    Publication date: February 12, 2026
    Applicant: Arcus Biosciences, Inc.
    Inventors: Joshua R. Corbin, Sandeep Dhanju, Corinne Nicole Foley, Jeremy Fournier, Padmanabha V. Kattamuri, Manjunath Lamani, Manmohan Reddy Leleti, Pradeep Nareddy, Ehesan Ul Sharif, Joice Thomas, Monika Yadav
  • AXL COMPOUNDS
    Publication number: 20240246967
    Abstract: Compounds of Formula I that inhibit AXL, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by AXL.
    Type: Application
    Filed: May 20, 2022
    Publication date: July 25, 2024
    Inventors: Corinne Nicole FOLEY, Manjunath LAMANI, Manmohan Reddy LELETI, Dillon Harding MILES, Pradeep NAREDDY, Srinivas PALADUGU, Jay Patrick POWERS, Shiwei QU, Joice THOMAS, Ehesan Ul SHARIF, Rebecca Louise GRANGE, Guiling ZHAO
  • INHIBITORS OF HPK1 AND METHODS OF USE THEREOF
    Publication number: 20240124490
    Abstract: Disclosed herein are compounds that are Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors having a structure according to Formula I, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
    Type: Application
    Filed: July 6, 2023
    Publication date: April 18, 2024
    Applicant: Arcus Biosciences, Inc.
    Inventors: Joshua R. Corbin, Sandeep Dhanju, Corinne Nicole Foley, Jeremy Fournier, Padmanabha V. Kattamuri, Manmohan Reddy Leleti, Pradeep Nareddy, Jay Patrick Powers, Ehesan Ul Sharif, Joice Thomas
  • OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20230111856
    Abstract: The first selective SuFEx antagonists to ?-opioid receptors (MOR) were developed by functionalizing an opioid scaffold with an SO2—F warhead. Our model, based on a MOR structure with antagonist ?-FNA, indicates the naloxone carbonyl as an advantageous point for derivatization as it is chemically accessible and is not involved in interaction with receptors. Of the three accessible Tyr residues in MOR pocket, Tyr77, Tyr130 and Tyr150, Tyr150 in proximity to the carbonyl of the docked naloxone was selected as a target, which resulted in the development of highly potent antagonists.
    Type: Application
    Filed: March 2, 2021
    Publication date: April 13, 2023
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Vsevolod KATRITCH, Valery V. FOKIN, Saheem ZAIDI, Joice THOMAS
  • Anti-cancer compounds
    Patent number: 9278958
    Abstract: The present invention relates to compounds having cytostatic activity against tumor cells. The compounds of the invention are of formula (I), or derivatives hereof, wherein R0, R1, R2, A, and X have defined meanings as described in claim 1.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 8, 2016
    Assignees: Katholieke Universiteit Leuven K.U. Leuven R&D, Universita Degli Studi Di Ferrara
    Inventors: Jan Balzarini, Wim Dehaen, Joice Thomas, Sandra Liekens, Romeo Romagnoli, Pier Giovanni Baraldi
  • NOVEL ANTI-CANCER COMPOUNDS
    Publication number: 20150126559
    Abstract: The present invention relates to compounds having cytostatic activity against tumor cells. The compounds of the invention are of formula (I), or derivatives hereof, wherein R0, R1, R2, A, and X have defined meanings as described in claim 1.
    Type: Application
    Filed: June 21, 2013
    Publication date: May 7, 2015
    Applicant: UNIVERSITA DEGLI STUDI DI FERRARA
    Inventors: Jan Balzarini, Wim Dehaen, Joice Thomas, Sandra Liekens, Romeo Romagnoli, Pier Giovanni Baraldi