Patents by Inventor Joice Thomas

Joice Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF HPK1 AND METHODS OF USE THEREOF
    Publication number: 20240124490
    Abstract: Disclosed herein are compounds that are Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors having a structure according to Formula I, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.
    Type: Application
    Filed: July 6, 2023
    Publication date: April 18, 2024
    Applicant: Arcus Biosciences, Inc.
    Inventors: Joshua R. Corbin, Sandeep Dhanju, Corinne Nicole Foley, Jeremy Fournier, Padmanabha V. Kattamuri, Manmohan Reddy Leleti, Pradeep Nareddy, Jay Patrick Powers, Ehesan Ul Sharif, Joice Thomas
  • OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20230111856
    Abstract: The first selective SuFEx antagonists to ?-opioid receptors (MOR) were developed by functionalizing an opioid scaffold with an SO2—F warhead. Our model, based on a MOR structure with antagonist ?-FNA, indicates the naloxone carbonyl as an advantageous point for derivatization as it is chemically accessible and is not involved in interaction with receptors. Of the three accessible Tyr residues in MOR pocket, Tyr77, Tyr130 and Tyr150, Tyr150 in proximity to the carbonyl of the docked naloxone was selected as a target, which resulted in the development of highly potent antagonists.
    Type: Application
    Filed: March 2, 2021
    Publication date: April 13, 2023
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Vsevolod KATRITCH, Valery V. FOKIN, Saheem ZAIDI, Joice THOMAS
  • Anti-cancer compounds
    Patent number: 9278958
    Abstract: The present invention relates to compounds having cytostatic activity against tumor cells. The compounds of the invention are of formula (I), or derivatives hereof, wherein R0, R1, R2, A, and X have defined meanings as described in claim 1.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 8, 2016
    Assignees: Katholieke Universiteit Leuven K.U. Leuven R&D, Universita Degli Studi Di Ferrara
    Inventors: Jan Balzarini, Wim Dehaen, Joice Thomas, Sandra Liekens, Romeo Romagnoli, Pier Giovanni Baraldi
  • NOVEL ANTI-CANCER COMPOUNDS
    Publication number: 20150126559
    Abstract: The present invention relates to compounds having cytostatic activity against tumor cells. The compounds of the invention are of formula (I), or derivatives hereof, wherein R0, R1, R2, A, and X have defined meanings as described in claim 1.
    Type: Application
    Filed: June 21, 2013
    Publication date: May 7, 2015
    Applicant: UNIVERSITA DEGLI STUDI DI FERRARA
    Inventors: Jan Balzarini, Wim Dehaen, Joice Thomas, Sandra Liekens, Romeo Romagnoli, Pier Giovanni Baraldi