Abstract: A fundus imaging device includes an objective optical system formed of a plurality of eccentrically disposed mirrors, and an SLO optical system and an OCT optical system which irradiate a fundus with light from a light source via the objective optical system and receive fundus reflected light. The fundus imaging device further includes a correction mirror as a part of the objective optical system, or between the objective optical system and the SLO optical system or the OCT optical system. The correction mirror corrects an eccentric aberration which occurs due to eccentric arrangement of the plurality of mirrors.

Abstract: A fundus imaging device includes an objective optical system formed of a plurality of eccentrically disposed mirrors, and an SLO optical system and an OCT optical system which irradiate a fundus with light from a light source via the objective optical system and receive fundus reflected light. The fundus imaging device further includes a correction mirror as a part of the objective optical system, or between the objective optical system and the SLO optical system or the OCT optical system. The correction mirror corrects an eccentric aberration which occurs due to eccentric arrangement of the plurality of mirrors.

Abstract: An ophthalmic photographing apparatus is provided with a SLO optical system including a first optical scanner for scanning a laser beam to obtain a front image of an examinee's eye by the laser beam, a OCT optical system including a second optical scanner for scanning measurement light to obtain a tomographic image of the examinee's eye by use of interference between the measurement light and reference light, an optical path combiner for combining optical paths of the SLO optical system and the OCT optical system, an objective lens system placed between the optical path combiner and the examinee's eye, and a relay lens system placed between the second optical scanner and the optical path combiner. The second optical scanner is placed on a side closer to the relay lens system than a focal point distance of the relay lens is.

Abstract: An ophthalmic photographing apparatus is provided with a SLO optical system including a first optical scanner for scanning a laser beam to obtain a front image of an examinee's eye by the laser beam, a OCT optical system including a second optical scanner for scanning measurement light to obtain a tomographic image of the examinee's eye by use of interference between the measurement light and reference light, an optical path combiner for combining optical paths of the SLO optical system and the OCT optical system, an objective lens system placed between the optical path combiner and the examinee's eye, and a relay lens system placed between the second optical scanner and the optical path combiner. The second optical scanner is placed on a side closer to the relay lens system than a focal point distance of the relay lens is.

Abstract: There is provided a process for producing a bicyclo [3.1.0] hexane derivative represented by the formula (I) and a salt thereof including; causing an enzyme to act on an optically inactive compound represented by the formula (II) causing an asymmetric acylation reaction and a highly-stereoselective conversion to an optically active compound represented by the formula (III); and converting the compound represented by the formula (III) to the compound represented by the formula (I) or a salt thereof.

Abstract: Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.

Abstract: There is provided a process for producing a bicyclo [3.1.0] hexane derivative represented by the formula (I) and a salt thereof including; causing an enzyme to act on an optically inactive compound represented by the formula (II) causing an asymmetric acylation reaction and a highly-stereoselective conversion to an optically active compound represented by the formula (III); and converting the compound represented by the formula (III) to the compound represented by the formula (I) or a salt thereof.

Abstract: Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.

Abstract: A method for introducing hydroxyl groups into vitamin D compound at the 1.alpha.- and/or 25-positions in the presence of a cyclodextrin compound by the use of a reaction mixture containing a microorganism being capable of hydroxylating vitamin D compound or a enzyme produced from the microorganism, is disclosed.

Abstract: Mucor circinelloides f. griseo-cyanus IFO 4563 is cultivated in a medium containing 6-O-methylerythromycin A as a substrate to obtain 14-hydroxy-6-O-methyl-erythromycin A. This compound and its salt have anti-bacterial activity.

Abstract: A method for introducing hydroxyl groups into vitamin D compounds at 1.alpha.- and/or 25-positions by use of a solution containing the mycelium of Actinomycetales being capable of hydroxylating vitamin D compound or the enzyme produced from the mycelium, is disclosed.