Patents by Inventor Jon Antilla

Jon Antilla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N,N'-DI-P-BROMOPHENYL GUANIDINE TREATMENT FOR STROKE AT DELAYED TIMEPOINTS
    Publication number: 20110201688
    Abstract: 1,3 di-o-tolylguanidine (DTG) was examined as anti-stroke drug with a broad therapeutic window. DTG activates sigma 1 and 2 receptors. Administration of DTG at 24 hours post-stroke to rats reduces neurodegeneration by 85%; this is the only pharmacological agent that has been used successfully at this delayed timepoint. Treatment with DTG provides protection of neurons exposed to hypoxia and blocks activation of immune cells that are responsible for delayed neurodegeneration associated with stroke. Disclosed is an altered DTG structure, placing a bromide at the para position to increase tissue penetrance and efficacy. Results show that N,N?-di-p-bromophenyl guanidine protects cultured neurons under hypoxic conditions but is more potent than DTG. Moreover, N,N?-di-p-bromophenyl guanidine is as least as efficacious as DTG in treating rats 24 hours after experimental stroke.
    Type: Application
    Filed: April 20, 2011
    Publication date: August 18, 2011
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Keith Pennypacker, Javier Cuevas, Jon Antilla, Michelle Cortes-Salva
  • Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
    Publication number: 20060264673
    Abstract: The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate.
    Type: Application
    Filed: May 9, 2006
    Publication date: November 23, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Stephen Buchwald, Artis Klapars, Jon Antilla, Gabriel Job, Martina Wolter, Fuk Kwong, Gero Nordmann, Edward Hennessy
  • Copper-catalyzed formation of carbon heteroatom and carbon-carbon bonds
    Publication number: 20050215794
    Abstract: The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate.
    Type: Application
    Filed: January 4, 2005
    Publication date: September 29, 2005
    Inventors: Stephen Buchwald, Artis Klapars, Jon Antilla, Gabriel Job, Martina Wolter, Fuk Kwong, Gero Nordmann, Edward Hennessy
  • Catalytic asymmetric synthesis of chiral aziridines
    Patent number: 6258960
    Abstract: The present invention relates to the synthesis of chiral cis-aziridines (IIIa and IIIb) by reacting an imine (I) with a diazo compound (II) in the presence of a chiral vaulted biary-Lewis Acid complex as shown below:
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: July 10, 2001
    Assignee: Arch Development Corporation
    Inventors: Jon Antilla, William D. Wulff