Patents by Inventor Jon B. Klein

Jon B. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10041956
    Abstract: Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: August 7, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Michael L. Merchant, Jon B. Klein, Michael E. Brier, Adam E. Gaweda
  • Publication number: 20150247868
    Abstract: Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent.
    Type: Application
    Filed: May 14, 2015
    Publication date: September 3, 2015
    Inventors: Michael L. Merchant, Jon B. Klein, Michael E. Brier, Adam E. Gaweda
  • Patent number: 9057731
    Abstract: Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: June 16, 2015
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Michael L. Merchant, Jon B. Klein, Michael E. Brier, Adam E. Gaweda
  • Patent number: 8394601
    Abstract: Methods and kits are provided for diagnosing a kidney disease, or the risk thereof, in a subject. The methods include determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: March 12, 2013
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Jon B. Klein, Michael Merchant, Grzegorz Boratyn
  • Publication number: 20120009606
    Abstract: The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.
    Type: Application
    Filed: September 16, 2011
    Publication date: January 12, 2012
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Jon B. Klein, Michael Merchant, Grzegorz Boratyn
  • Publication number: 20110318761
    Abstract: Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17.
    Type: Application
    Filed: June 23, 2011
    Publication date: December 29, 2011
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Michael L. Merchant, Jon B. Klein, Michael E. Brier, Adam E. Gaweda
  • Patent number: 8039227
    Abstract: Methods for diagnosing a kidney disease, or the risk thereof, in a subject are provided. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: October 18, 2011
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Jon B. Klein, Michael Merchant, Grzegorz Boratyn
  • Publication number: 20090081713
    Abstract: The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.
    Type: Application
    Filed: September 19, 2008
    Publication date: March 26, 2009
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Jon B. Klein, Michael Merchant, Grzegorz Boratyn
  • Patent number: 5248499
    Abstract: The invention relates in general to the prevention and treatment of microbial infections in transplant patients. More particularly, the invention concerns the use of lymphokines, and specifically gamma interferon (IFN-.gamma.) for the prophylaxis and treatment of microbial infections in transplant recipients, without increasing the incidence of graft rejections.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: September 28, 1993
    Assignee: Genentech, Inc.
    Inventors: Christine Czarniecki, Jon B. Klein, A. David Slater, Gerald Sonnenfeld