Abstract: Methods of determining suitability to be treated with an immunotherapy comprising receiving a sample from the subject and determining the presence of Ly6E expressing neutrophils in the sample, wherein the presence of the Ly6E neutrophils indicates the subject is suitable for treatment are provided. Pharmaceutical composition comprising Ly6E neutrophils, and methods of treatment by administering Ly6E neutrophils are also provided.

Abstract: An apparatus for detecting anomalies in an acoustic signal, the apparatus including: one or more microphones for receiving an acoustic signal of an environment; and a processor implementing: an acoustic signal processing module configured to: analyse the acoustic signal to identify anomalies in the acoustic signal indicative of events occurring in the environment; and classify the anomalies in the acoustic signal into one or more event classifications; and a communications module configured to output the one or more event classifications, wherein the apparatus is located in the environment and includes an environmental enclosure arranged to house the processor and to protect the processor from environmental contaminants.

Abstract: An apparatus for detecting anomalies in an acoustic signal, the apparatus including: one or more microphones for receiving an acoustic signal of an environment; and a processor implementing: an acoustic signal processing module configured to: analyse the acoustic signal to identify anomalies in the acoustic signal indicative of events occurring in the environment; and classify the anomalies in the acoustic signal into one or more event classifications; and a communications module configured to output the one or more event classifications, wherein the apparatus is located in the environment and includes an environmental enclosure arranged to house the processor and to protect the processor from environmental contaminants.

Abstract: The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI.

Abstract: The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI.

Abstract: The present invention relates to materials and methods for performing assays directed to monitoring activity and function of intracellular components, such as proteins associated with organelles and other intracellular structures. In particular, the invention relates to permeabilised cell preparations and their use in studying activity of intracellular components, in particular for studying sarcoplasmic reticulum function.

Abstract: A thermoelectric sensor for monitoring biological samples is provided, the sensor comprising a substrate (26) having a plurality of thermocouple sensing junctions (18) arranged circularly about a central region, a number of reference junctions (30) arranged about the sensing junctions (18), and a low thermal mass air cavity (32) provided adjacent to the sensing junctions. A heating element (16) may also be provided. The sensor of the invention may be used to monitor temperature changes from individual cells or groups of cells, or from biologically active compounds or samples, as a result of biological activity. The sensor may thus be used for screening candidate drugs and the like.

Abstract: An implantable, refillable, rate-controlled drug delivery device, with a hollow reservoir, and a drug delivery tube communicating with the hollow reservoir. The drug delivery tube includes at least one rate-limiting permeable membrane which regulates drug delivery. A method of controlling the delivery of a drug to an internal portion of a body is disclosed.