Abstract: Polyfluorinated compounds are disclosed, including polyfluorinated cannabinoid and cannabinoid-like compounds. Also disclosed are methods of producing the polyfluorinated compounds.

Abstract: The present invention provides methods and materials for use in increasing HSP20 activation in a biological system, for example by increasing phosphorylation of Ser16 of HSP20. In one aspect, the invention provides a method for increasing HSP20 activation in a biological system, comprising contacting the system with an antagonist capable of inhibiting PDE4 binding to HSP20, the antagonist comprising or consisting essentially of a fragment of PDE4 or an analogue thereof. In a further aspect the invention provides a method of screening for an agent able to increase activation of HSP20. A preferred antagonist has a C-terminal lysine residue.

Abstract: A brewable coffee product usable to produce a coffee beverage. A first version coffee product includes ground roasted coffee, cocoa, a vanilla flavoring ingredient, and wheat, oats, corn, or barley flakes, or combinations thereof. One or more additional flavoring ingredients may be included such as mint, cinnamon, peppermint, or maple syrup. The coffee product may be individually packaged for single cup dipping. A second version of the coffee product includes ground roasted coffee and a plurality of elongate, non-toxic flow-facilitating members in the form of spaghetti, macaroni, noodles, or a combination thereof which facilitate flow of brewing water through the product during drip brewing. The pasta product also raises the pH of the coffee beverage brewed therewith to reduce acidity thereof.