Patents by Inventor Jon E. Adler

Jon E. Adler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using T1R hetero-oligomeric taste receptors to screen for compounds which modulate sweet or umami taste signaling
    Patent number: 10591464
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: March 17, 2020
    Assignee: Firmenich Incorporated
    Inventors: Jon E. Adler, Xiaodong Li, Lena Luukkonen, Hong Xu, Fernando Echeverri
  • T1R HETERO-OLIGOMERIC TASTE RECEPTORS
    Publication number: 20190212329
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Application
    Filed: August 28, 2018
    Publication date: July 11, 2019
    Inventors: JON E. ADLER, XIAODONG LI, LENA LUUKKONEN, HONG XU, FERNANDO ECHEVERRI
  • Methods of using TIR hetero-oligomeric receptors for screening compounds that modulate sweet or umami taste
    Patent number: 10088472
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: October 2, 2018
    Assignee: SENOMYX, INC.
    Inventors: Jon E. Adler, Xiaodong Li, Lena Luukkonen, Hong Xu, Fernando Echeverri
  • METHOD FOR IDENTIFYING COMPOUNDS THAT MODULATE A T2R TASTE RECEPTOR
    Publication number: 20180128842
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Application
    Filed: October 17, 2017
    Publication date: May 10, 2018
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Method for identifying compounds that modulate a T2R taste receptor
    Patent number: 9817000
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: November 14, 2017
    Assignee: The Regents of the University of California
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • T1R HETERO-OLIGOMERIC TASTE RECEPTORS
    Publication number: 20170219567
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Application
    Filed: September 14, 2016
    Publication date: August 3, 2017
    Inventors: Jon E. ADLER, Xiaodong Li, Lena Luukkonen, Hong Xu, Fernando Echeverri
  • Methods of screening T1R hetero-oligomeric taste receptors for sweet taste modulators
    Patent number: 9476869
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: October 25, 2016
    Assignee: Senomyx, Inc.
    Inventors: Jon E. Adler, Xiaodong Li, Lena Luukkonen, Hong Xu, Fernando Echeverri
  • METHOD FOR IDENTIFYING COMPOUNDS THAT MODULATE A T2R TASTE RECEPTOR
    Publication number: 20150260733
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Application
    Filed: May 19, 2015
    Publication date: September 17, 2015
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Method for identifying compounds that modulate a T2R taste receptor
    Patent number: 9063124
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: June 23, 2015
    Assignee: The Regents of the University of California
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • T1R Hetero-Oligomeric Taste Receptors
    Publication number: 20150024407
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Application
    Filed: July 22, 2014
    Publication date: January 22, 2015
    Inventors: Jon E. ADLER, Xiaodong LI, Lena STASZEWSKI, Hong XU, Fernando ECHEVERRI
  • Methods of screening heteromeric T1R2/T1R3 receptors for compounds which modulate sweet taste signaling
    Patent number: 8809000
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: August 19, 2014
    Assignee: Senomyx, Inc.
    Inventors: Jon E. Adler, Xiaodong Li, Lena Staszewski, Hong Xu, Fernando Echeverri
  • T2R, A NOVEL FAMILY OF TASTE RECEPTORS
    Publication number: 20140120553
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Application
    Filed: November 20, 2013
    Publication date: May 1, 2014
    Applicant: The Regents of the University of California
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Nucleic acids encoding T2R bitter taste receptors
    Patent number: 8624012
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: January 7, 2014
    Assignee: The Regents of the University of California
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • Methods for identifying compounds which modulate T2R bitter taste receptors
    Patent number: 8580527
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: November 12, 2013
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Mark Hoon, Nick Ryba, Ken Mueller
  • Nucleic acid encoding a T2R taste receptor
    Patent number: 8329885
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: December 11, 2012
    Assignees: The Regents of the University of California, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Charles Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • NUCLEIC ACIDS ENCODING A G-PROTEIN COUPLED RECEPTOR INVOLVED IN SENSORY TRANSDUCTION
    Publication number: 20120142029
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
    Type: Application
    Filed: November 4, 2011
    Publication date: June 7, 2012
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Juergen Lindemeier
  • Methods of indentifying sweet taste modulators
    Patent number: 8119359
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: February 21, 2012
    Assignee: Senomyx, Inc.
    Inventors: Jon E. Adler, Xiaodong Li, Lena Staszewski, Hong Xu, Fernando Echeverri
  • T2R, A NOVEL FAMILY OF TASTE RECEPTORS
    Publication number: 20120009598
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Application
    Filed: December 13, 2010
    Publication date: January 12, 2012
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
  • NUCLEIC ACIDS ENCODING A G-PROTEIN COUPLED RECEPTOR INVOLVED IN SENSORY TRANSDUCTION
    Publication number: 20110105741
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
    Type: Application
    Filed: December 3, 2010
    Publication date: May 5, 2011
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zucker, Jon E. Adler, Juergen Lindemeier
  • Nucleic acids encoding T2R taste receptors
    Patent number: 7868150
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: January 11, 2011
    Assignee: The Regents of the University of California
    Inventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon