Patents by Inventor Jon F. Kayyem
Jon F. Kayyem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20100028984Abstract: The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips comprise a substrate that includes an array of detection electrodes, each including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contacts, detecting current as an indication of the presence of the labels on the first biochip and detecting current as an indication of the presence of the labels on the second biochip.Type: ApplicationFiled: July 17, 2007Publication date: February 4, 2010Inventors: Hau H. DUONG, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Robert H. Terbrueggen
-
Publication number: 20080202927Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: ApplicationFiled: January 25, 2007Publication date: August 28, 2008Applicant: Clinical Micro Sensors, Inc.Inventors: Jon F. Kayyem, Stephen D. O'Connor
-
Patent number: 7384749Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.Type: GrantFiled: January 30, 2006Date of Patent: June 10, 2008Assignee: Clinical Micro Sensors, Inc.Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
-
Patent number: 7381533Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.Type: GrantFiled: December 6, 2005Date of Patent: June 3, 2008Assignee: Clinical Micro Sensors, Inc.Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
-
Patent number: 7312087Abstract: The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: GrantFiled: January 11, 2001Date of Patent: December 25, 2007Assignee: Clinical Micro Sensors, Inc.Inventors: Hau H. Duong, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Robert H. Terbrueggen
-
Patent number: 7045285Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.Type: GrantFiled: April 21, 2000Date of Patent: May 16, 2006Assignee: Clinical Micro Sensors, Inc.Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
-
Patent number: 7033760Abstract: The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.Type: GrantFiled: August 3, 2001Date of Patent: April 25, 2006Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon F. Kayyem
-
Patent number: 6962686Abstract: A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.Type: GrantFiled: October 11, 1995Date of Patent: November 8, 2005Assignee: California Institute of TechnologyInventors: Jon F. Kayyem, Thomas J. Meade, Scott E. Fraser
-
Publication number: 20050074403Abstract: A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.Type: ApplicationFiled: October 11, 1995Publication date: April 7, 2005Inventors: JON F. KAYYEM, THOMAS J. MEADE, SCOTT E. FRASER
-
Publication number: 20030150723Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.Type: ApplicationFiled: September 5, 2002Publication date: August 14, 2003Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu
-
Publication number: 20020177135Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: ApplicationFiled: July 11, 2001Publication date: November 28, 2002Inventors: Hau H. Doung, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Nathan Swami, Robert H. Terbrueggen
-
Patent number: 6479240Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.Type: GrantFiled: May 22, 2000Date of Patent: November 12, 2002Assignee: Clinical Micro Sensors, Inc.Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu
-
Publication number: 20020034759Abstract: The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.Type: ApplicationFiled: August 3, 2001Publication date: March 21, 2002Applicant: California Institute of TechnologyInventors: Thomas J. Meade, Jon F. Kayyem
-
Patent number: 6291188Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: August 15, 2000Date of Patent: September 18, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon F. Kayyem
-
Patent number: 6265155Abstract: The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.Type: GrantFiled: February 28, 1997Date of Patent: July 24, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon F. Kayyem
-
Patent number: 6096273Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.Type: GrantFiled: November 5, 1996Date of Patent: August 1, 2000Assignee: Clinical Micro SensorsInventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
-
Patent number: 5591578Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of the nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes. Hybridization assays employing these complexes are disclosed.Type: GrantFiled: December 10, 1993Date of Patent: January 7, 1997Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon F. Kayyem, Scott E. Fraser