Abstract: Percutaneous therapy or drug delivery devices are described herein. The device can include one or multiple lumens inside a cannula or catheter body. The device can include features for reducing or preventing backflow or reflux of infusate along the device insertion track, such as one or more bullet noses, over tubes, and/or micro-tips. The device can be used in any of a variety of treatment methods, including to inject cancer therapy medicinal products directly into pulmonary tumors or tumors located in other regions of the body. The device can include features to keep the distal tip secure during patient respiration or during other patient movement, and can reduce the incidence of reflux during therapy delivery.