Patents by Inventor Jon H. Astle
Jon H. Astle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080194043Abstract: The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1? or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1? or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1? or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.Type: ApplicationFiled: March 21, 2008Publication date: August 14, 2008Inventors: Jon H. ASTLE, Christopher C. BURGESS, Theodore J. CATINO, Poornima DWIVEDI, Maryanne HUNTRESS, Karen Anne JOHNSON, Marcia E. LEWIS, Peter J. MAIMONIS, Gary A. MOLINO, Susan H. MYEROW, Arunthathi THIAGALINGAM, Lisa Allyn BOARDMAN, Lawrence J. BURGART, Stephen N. THIBODEAU, Sheryl BROWN-SHIMER
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Publication number: 20080131889Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: April 30, 2007Publication date: June 5, 2008Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam
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Patent number: 7258973Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: GrantFiled: July 17, 2001Date of Patent: August 21, 2007Assignees: Mayo Foundation for Medical Education & Research, Bayer Healthcare, LLCInventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen Thibodeau, Lawrence J. Burgart, Lisa Allyn Boardman
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Patent number: 7211398Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: GrantFiled: October 25, 2002Date of Patent: May 1, 2007Assignees: Bayer Corporation, Mayo Foundation for Medical Education and ResearchInventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen Thibodeau, Lawrence J. Burgart, Lisa Allyn Boardman
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Publication number: 20040157278Abstract: The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1&agr; or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1&agr; or TIMP1 expression is indicative of the presence of colorectal cancer. The invention further relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1&agr; or TIMP1 nucleic acid or amino acid molecules in a clinical sample, in addition to detecting the presence of one or more additional colorectal cancer associated markers.Type: ApplicationFiled: December 12, 2003Publication date: August 12, 2004Applicants: Bayer Corporation, Mayo Foundation for Medical Education & ResearchInventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Maryanne Huntress, Karen Anne Johnson, Marcia E. Lewis, Peter J. Maimonis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Lisa Allyn Boardman, Lawrence J. Burgart, Stephen N. Thibodeau, Sheryl Brown-Shimer
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Publication number: 20040146879Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: June 30, 2003Publication date: July 29, 2004Applicants: Bayer HealthCare LLC, Mayo Foundation for Medical Education & ResearchInventors: Jon H. Astle, Lisa Allyn Boardman, Lawrence J. Burgart, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam, Stephen N. Thibodeau
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Publication number: 20040110668Abstract: This invention relates to novel nucleic acid sequences which are differentially expressed in cancer cells. The invention also relates to proteins and peptides encoded by the sequences, to diagnostic assays and therapeutic agents based on the sequences and proteins, and to probes, antisense constructs, and antibodies derived from the sequences and proteins or peptides. The subject nucleic acids have been found to be differentially expressed by tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: October 2, 2001Publication date: June 10, 2004Inventors: Christopher C. Burgess, Jon H. Astle, Eddie Carroll, Theodore J. Catino, Poornima Dwivedi, Gary A. Molino, Arunthathi Thiagalingam, Marcia E. Lewis
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Publication number: 20030097666Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: May 31, 2001Publication date: May 22, 2003Inventors: Wilson O. Endege, Kathleen E. Steinmann, Jon H. Astle, Christopher C. Burgess, Eddie Carroll, Theodore J. Catino, Poornima Dwivedi, Donna M. Ford, Marcia E. Lewis, Gary A. Molino, John E. Mohahan, Robert Schlegel
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Publication number: 20030082620Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: October 25, 2002Publication date: May 1, 2003Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam
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Publication number: 20020192699Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The invention further relates to polynucleotides differentially expressed in prostate cancer.Type: ApplicationFiled: July 23, 2002Publication date: December 19, 2002Applicant: Chiron CorporationInventors: Jimmy Zhang, Jon H. Astle, Eddie Carroll, Wilson O. Endege, Donna M. Ford, John E. Monahan, Robert Schlegel, Kathleen E. Steinmann
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Patent number: 6476207Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The invention further relates to polynucleotides differentially expressed in prostate cancer.Type: GrantFiled: June 9, 1999Date of Patent: November 5, 2002Assignee: Chiron CorporationInventors: Jimmy Zhang, Jon H. Astle, Eddie Carroll, III, Wilson O. Endege, Donna M. Ford, John E. Monahan, Robert Schlegel, Kathleen E. Steinmann
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Publication number: 20020144298Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly colon cancer cell lines and/or tissue.Type: ApplicationFiled: June 11, 2001Publication date: October 3, 2002Inventors: Wilson O. Endege, Kathleen E. Steinmann, Jon H. Astle, Christopher C. Burgess, Steven E. Bushnell, Eddie Carroll, Theodore J. Catino, Adnan Derti, Donna M. Ford, Marcia E. Lewis, John E. Mohahan, Robert Schlegel
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Publication number: 20020034758Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: ApplicationFiled: July 17, 2001Publication date: March 21, 2002Inventors: Jon H. Astle, Christopher C. Burgess, Theodore J. Catino, Poornima Dwivedi, Marcia E. Lewis, Gary A. Molino, Susan H. Myerow, Arunthathi Thiagalingam
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Patent number: 6262333Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs. and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly colon cancer cell lines and/or tissue.Type: GrantFiled: June 8, 1999Date of Patent: July 17, 2001Assignee: Bayer CorporationInventors: Wilson O. Endege, Kathleen E. Steinmann, Jon H. Astle, Christopher C. Burgess, Steven E. Bushnell, Eddie Carroll, III, Theodore J. Catino, Adnan Derti, Donna M. Ford, Marcia E. Lewis, John E. Monahan, Robert Schlegel
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Patent number: 6262334Abstract: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.Type: GrantFiled: August 30, 1999Date of Patent: July 17, 2001Assignee: Bayer CorporationInventors: Wilson O. Endege, Kathleen E. Steinmann, Jon H. Astle, Christopher C. Burgess, Eddie Carroll, III, Theodore J. Catino, Poornima Dwivedi, Donna M. Ford, Marcia E. Lewis, Gary A. Molino, John E. Monahan, Robert Schlegel