Patents by Inventor Jon Helge Hoem
Jon Helge Hoem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230381415Abstract: Methods and devices for the diagnosis and treatment of microvascular dysfunction, such as microvascular obstruction (MVO) and other dysfunctional diseases of the microvasculature of many organs, including the heart. The present subject matter provides novel devices and methods to successfully diagnose, restore patency, open and preserve flow, and limit reperfusion injury in organs and cases with microvascular dysfunction. The present subject matter provides apparatus and method to detect, measure and treat microvascular dysfunction in real time during scenarios such as invasive angiographic/therapeutic procedures. Such procedures include therapy for organ systems including the heart (acute myocardial infarction—primary percutaneous coronary intervention (PPCI)), brain stroke (CVA), bowel ischemia/infarction, pulmonary emboli/infarction, critical limb ischemia/infarction, renal ischemia/infarction, and others.Type: ApplicationFiled: August 9, 2023Publication date: November 30, 2023Applicant: CorFlow Therapeutics AGInventors: Robert S. SCHWARTZ, Jon Helge HOEM, Martin T. ROTHMAN
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Patent number: 11724030Abstract: Methods and devices for the diagnosis and treatment of microvascular dysfunction, such as microvascular obstruction (MVO) and other dysfunctional diseases of the microvasculature of many organs, including the heart. The present subject matter provides novel devices and methods to successfully diagnose, restore patency, open and preserve flow, and limit reperfusion injury in organs and cases with microvascular dysfunction. The present subject matter provides apparatus and method to detect, measure and treat microvascular dysfunction in real time during scenarios such as invasive angiographic/therapeutic procedures. Such procedures include therapy for organ systems including the heart (acute myocardial infarction—primary percutaneous coronary intervention (PPCI)), brain stroke (CVA), bowel ischemia/infarction, pulmonary emboli/infarction, critical limb ischemia/infarction, renal ischemia/infarction, and others.Type: GrantFiled: September 20, 2019Date of Patent: August 15, 2023Assignee: CorFlow Therapeutics AGInventors: Robert S. Schwartz, Jon Helge Hoem, Martin T. Rothman
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Publication number: 20220378301Abstract: Systems and apparatus are included that are configured to determine the effectiveness of apparatus and methods used to diagnose and unblock microvascular obstruction (MVO). An infusion system blocks antegrade flow for a short time and measures vascular pressure response as an infusate is infused in stepwise fashion at increasingly higher flowrates. During the antegrade flow occlusion, calculations of the real-time vascular resistance can be obtained using the formula R(t)=P(t)/Qmean(t) where: Qmean(t) is the flow mean values generated by the infusion system; P(t) is the distal pressure response in the vessel generated from the flow infusion; and R(t) is the calculated vascular resistance using the two other known parameters.Type: ApplicationFiled: August 12, 2022Publication date: December 1, 2022Applicant: CorFlow Therapeutics AGInventors: Robert S. SCHWARTZ, Jon Helge HOEM, Martin T. ROTHMAN
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Patent number: 11433183Abstract: Devices for the diagnosis and treatment of microvascular obstruction (MVO) and other dysfunctional diseases of the microvasculature of many organs, including the heart. The present subject matter provides novel devices and methods to detect and measure or treat MVO in real time during scenarios such as invasive angiographic/therapeutic procedures. Such procedures include therapy for organ systems including the heart (acute myocardial infarction-primary percutaneous coronary intervention (PPCI)), brain stroke (CVA), bowel ischemia/infarction, pulmonary emboli/infarction, critical limb ischemia/infarction, renal ischemia/infarction, and others. Using methods of the invention, a system comprising specialized infusion and sensing catheter, diagnostic agents, therapeutic agents, and control console with specialized algorithms can both diagnose and treat MVO by eliminating the microvascular clot and debris causing the obstruction.Type: GrantFiled: March 8, 2019Date of Patent: September 6, 2022Assignee: CorFlow Therapeutics AGInventors: Robert S. Schwartz, Jon Helge Hoem, Martin T. Rothman
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Patent number: 11412936Abstract: Systems and apparatus are included that are configured to determine the effectiveness of apparatus and methods used to diagnose and unblock microvascular obstruction (MVO). An infusion system blocks antegrade flow for a short time and measures vascular pressure response as an infusate is infused in stepwise fashion at increasingly higher flowrates. During the antegrade flow occlusion, calculations of the real-time vascular resistance can be obtained using the formula R(t)=P(t)/Qmean(t) where: Qmean (t) is the flow mean values generated by the infusion system; P(t) is the distal pressure response in the vessel generated from the flow infusion; and R(t) is the calculated vascular resistance using the two other known parameters.Type: GrantFiled: September 19, 2018Date of Patent: August 16, 2022Assignee: CorFlow Therapeutics AGInventors: Jon Helge Hoem, Robert S. Schwartz, Martin T. Rothman
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Publication number: 20210361170Abstract: Methods and systems are provided for diagnosis and/or treatment of microvascular dysfunction, such as microvascular obstruction (MVO), in which the effects of collateral flow around a treatment site are addressed by injecting volumetric flows into a vessel using an infusion system to prevent or render negligible the collateral flow. Arterial pressures and fluidic flow rates sufficient to negate the collateral flow may be used to indicate the presence and/or severity of MVO for diagnostic and/or therapeutic purposes.Type: ApplicationFiled: May 21, 2021Publication date: November 25, 2021Inventors: Robert S. SCHWARTZ, Jon Helge HOEM, Sabrina FREY, Oliver BLUDAU
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Publication number: 20210366620Abstract: Systems, methods and apparatus are included that are configured to model microvascular obstruction (MVO) in patients. According to one aspect of the present disclosure, a multi-scale model is configured to mimic myocardial microcirculation of coronary vessels. The model includes collaterals configured to provide alternative pathways possibly bypassing the MVO, and configured to model coronary artery compliance for spatially resolved fluid transport through the coronary vessels. The model is configured to simulate the MVO by increasing flow resistance in at least one of the modelled coronary vessels, or by blocking the at least one of the modelled coronary vessels completely. The model is also configured to mimic behavior of fluid transport in the coronary vessels during diagnostics or treatment, to design and optimize therapy protocols for the MVO.Type: ApplicationFiled: May 31, 2019Publication date: November 25, 2021Applicants: CorFlow Therapeutics AG, Interstate University of Applied Sciences Buchs, University of BernInventors: Andre BERNARD, Peter HEEB, Cornelia NEF, Dominik OBRIST, Francesco CLAVICA, Sabrina FREY, Robert S. SCHWARTZ, Jon Helge HOEM, Oliver BLUDAU
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Publication number: 20200093991Abstract: Methods and devices for the diagnosis and treatment of microvascular dysfunction, such as microvascular obstruction (MVO) and other dysfunctional diseases of the microvasculature of many organs, including the heart. The present subject matter provides novel devices and methods to successfully diagnose, restore patency, open and preserve flow, and limit reperfusion injury in organs and cases with microvascular dysfunction. The present subject matter provides apparatus and method to detect, measure and treat microvascular dysfunction in real time during scenarios such as invasive angiographic/therapeutic procedures. Such procedures include therapy for organ systems including the heart (acute myocardial infarction—primary percutaneous coronary intervention (PPCI)), brain stroke (CVA), bowel ischemia/infarction, pulmonary emboli/infarction, critical limb ischemia/infarction, renal ischemia/infarction, and others.Type: ApplicationFiled: September 20, 2019Publication date: March 26, 2020Inventors: Robert S. Schwartz, Jon Helge Hoem, Martin T. Rothman
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Publication number: 20190275248Abstract: Devices for the diagnosis and treatment of microvascular obstruction (MVO) and other dysfunctional diseases of the microvasculature of many organs, including the heart. The present subject matter provides novel devices and methods to detect and measure or treat MVO in real time during scenarios such as invasive angiographic/therapeutic procedures. Such procedures include therapy for organ systems including the heart (acute myocardial infarction-primary percutaneous coronary intervention (PPCI)), brain stroke (CVA), bowel ischemia/infarction, pulmonary emboli/infarction, critical limb ischemia/infarction, renal ischemia/infarction, and others. Using methods of the invention, a system comprising specialized infusion and sensing catheter, diagnostic agents, therapeutic agents, and control console with specialized algorithms can both diagnose and treat MVO by eliminating the microvascular clot and debris causing the obstruction.Type: ApplicationFiled: March 8, 2019Publication date: September 12, 2019Inventors: Robert S. Schwartz, Jon Helge Hoem, Martin T. Rothman
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Publication number: 20190082976Abstract: Systems and apparatus are included that are configured to determine the effectiveness of apparatus and methods used to diagnose and unblock microvascular obstruction (MVO). An infusion system blocks antegrade flow for a short time and measures vascular pressure response as an infusate is infused in stepwise fashion at increasingly higher flowrates. During the antegrade flow occlusion, calculations of the real-time vascular resistance can be obtained using the formula R(t)=(t)/Qmean(t) where: Qmean (t) is the flow mean values generated by the infusion system; P(t) is the distal pressure response in the vessel generated from the flow infusion; and R(t) is the calculated vascular resistance using the two other known parameters.Type: ApplicationFiled: September 19, 2018Publication date: March 21, 2019Inventors: Jon Helge Hoem, Robert S. Schwartz, Martin T. Rothman