Abstract: Methods of determining a disease score of a patient diagnosed with lysosomal storage disease (LSD) are described. The disease score includes one or more of the following: (i) one or more biofluid biomarkers; (ii) one or more neurophysiological measurements; and (iii) one or more neurobehavior measurement. Also described method of treating LSD including determining the disease score and administering to the patient a therapy. The therapy includes one or more of the following: (i) enzyme replacement therapy, (ii) gene therapy; and (iii) a small molecule.

Abstract: A nanostructured article includes a substrate; a plurality of first nanostructures disposed on, and extending away from, the substrate; and a covalently crosslinked fluorinated polymeric layer disposed on the plurality of first nanostructures. The plurality of first nanostructures includes polyurethane. The polymeric layer at least partially fills spaces between the first nanostructures to an average minimum height above the substrate of at least 30 nm such that the polymeric layer has a nanostructured surface defined by, and facing away from, the plurality of first nanostructures.

Abstract: A method for manufacturing concrete from waste plastic. The waste plastic may be in the form of used baling twine. The used baling twine may contain residue from the baled material, such as hay, alfalfa, or other animal fodder, for example. This organic residue may include cellulose fibers, sugars, and alkalis from the fodder. Baling twine may be processed into a fiber which is then mixed into the cementitious mixture. Concrete made from such a mixture may have improved mechanical performance due to the included organic residue, such as increased tensile strength and energy absorption capabilities, for example.

Abstract: A method of detecting and warning an operator of an off-road vehicle of objects in limited-visibility environments. The method includes: detecting a potentially-hazardous object within the vicinity of the vehicle, using a sensor of the vehicle; transmitting data relating to the potentially-hazardous object to a vehicle processor; determining whether the potentially-hazardous object is in a projected path of the vehicle or in a proximity zone of the vehicle; and alerting the operator of the vehicle to the presence and location of the potentially-hazardous object when the potentially-hazardous object is in the projected path of the vehicle or in the proximity zone of the vehicle.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for optimizing a process of manufacturing a product. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for manufacturing a product, based on a causal model that measures causal relationships between input settings and a measure of a quality of the product; ii) determining the measure of the quality of the product manufactured using the configuration of input settings; and iii) adjusting, based on the measure of the quality of the product manufactured using the configuration of input settings, the causal model.

Abstract: A nanostructured article includes a substrate; a plurality of first nanostructures disposed on, and extending away from, the substrate; and a covalently crosslinked fluorinated polymeric layer disposed on the plurality of first nanostructures. The plurality of first nanostructures includes polyurethane. The polymeric layer at least partially fills spaces between the first nanostructures to an average minimum height above the substrate of at least 30 nm such that the polymeric layer has a nanostructured surface defined by, and facing away from, the plurality of first nanostructures.

Abstract: In a cloud system that includes a cloud server and multiple edge devices implementing the ThingWorx platform, an improved file transfer method for transferring multiple files from the edge device to a file repository of the cloud server. The method provides multi-level path traversal and copy from a specified root level, in a file system containing a plurality of nested variably named paths, with the abilities to exclude path(s) in the path traversal and copy, to specify custom date(s) in the past as the earliest date to transfer file(s), to specify and track copy retries, and to track and report file copy metrics.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: An integrated seal used in an air block of a transmission line conveying apparatus comprising: a ring-shaped front sealing member; a hollow cylindrical rear sealing member, the hollow cylindrical rear sealing member and the ring-shaped front sealing member sharing a central axis; and a connecting sealing member connecting the ring-shaped front sealing member and the hollow cylindrical rear sealing member.

Abstract: An external urine collection system for collecting urine excreted by a user through the user's external urethral orifice includes a urinary assembly having a sleeve and a cup that define a collection chamber. The sleeve can be attached to an area around the user's external urethral orifice by an adhesive. The cup can be coupled to the sleeve through a male connector and female connector that form a liquid tight seal between the sleeve and the cup. An outlet is defined by at least one of the sleeve and the cup for draining urine excreted by the user into the urinary assembly.

Abstract: The present disclosure relates to systems, methods, and computer readable media for modeling thermal effects within a multi-laser device. For example, systems described herein may include a plurality of laser devices that output energy streams having corresponding operating windows. One or more systems described herein may include a set of accumulators for tracking quantities of energy samples within operating windows and populating a queue representative of the tracked quantities. One or more systems described herein may additionally include filters and a summing module for determining temperature values for operating windows and synchronizing the temperature values with one another to determine an accurate system temperature for the multi-laser device. The features described herein facilitate synchronization of data for corresponding operating windows to provide an accurate determination of system temperature based on a combination of self-heating and crosstalk effects between multiple laser devices.

Abstract: The present disclosure relates to systems, methods, and computer readable media for modeling thermal effects within a multi-laser device. For example, systems described herein may include a plurality of laser devices that output energy streams having corresponding operating windows. One or more systems described herein may include a set of accumulators for tracking quantities of energy samples within operating windows and populating a queue representative of the tracked quantities. One or more systems described herein may additionally include filters and a summing module for determining temperature values for operating windows and synchronizing the temperature values with one another to determine an accurate system temperature for the multi-laser device. The features described herein facilitate synchronization of data for corresponding operating windows to provide an accurate determination of system temperature based on a combination of self-heating and crosstalk effects between multiple laser devices.

Abstract: The present disclosure relates to systems, methods, and computer readable media for modeling thermal effects within a multi-laser device. For example, systems described herein may include a plurality of laser devices that output energy streams having corresponding operating windows. One or more systems described herein may include a set of accumulators for tracking quantities of energy samples within operating windows and populating a queue representative of the tracked quantities. One or more systems described herein may additionally include filters and a summing module for determining temperature values for operating windows and synchronizing the temperature values with one another to determine an accurate system temperature for the multi-laser device. The features described herein facilitate synchronization of data for corresponding operating windows to provide an accurate determination of system temperature based on a combination of self-heating and crosstalk effects between multiple laser devices.

Abstract: Systems and methods are disclosed herein for providing improved cache structures and methods that are optimally sized to support a predetermined range of late stage adjustments and in which image data is intelligently read out of DRAM and cached in such a way as to eliminate re-fetching of input image data from DRAM and minimize DRAM bandwidth and power. The systems and methods can also be adapted to work with compressed image data and multiple LSR processing engines.

Abstract: Techniques for post-rendering image transformation including outputting an image frame including a plurality of first pixels by sequentially generating and outputting multiple color component fields including a first color component field and a second color component field by applying one or more two-dimensional (2D) image transformations to at least one portion of the plurality of source pixels by first, second, and third image transformation pipelines, to generate transformed pixel color data for the first color component field and the second color component field.

Abstract: Systems and methods are disclosed herein for providing improved cache structures and methods that are optimally sized to support a predetermined range of late stage adjustments and in which image data is intelligently read out of DRAM and cached in such a way as to eliminate re-fetching of input image data from DRAM and minimize DRAM bandwidth and power. The systems and methods can also be adapted to work with compressed image data and multiple LSR processing engines.

Abstract: Systems and methods are disclosed herein for providing improved cache structures and methods that are optimally sized to support a predetermined range of late stage adjustments and in which image data is intelligently read out of DRAM and cached in such a way as to eliminate re-fetching of input image data from DRAM and minimize DRAM bandwidth and power. The systems and methods can also be adapted to work with compressed image data and multiple LSR processing engines.

Abstract: Systems and methods are disclosed herein for providing improved cache structures and methods that are optimally sized to support a predetermined range of late stage adjustments and in which image data is intelligently read out of DRAM and cached in such a way as to eliminate re-fetching of input image data from DRAM and minimize DRAM bandwidth and power. The systems and methods can also be adapted to work with compressed image data.