Abstract: A pop up stopper comprising multiple aperture and at least one non-aperture lever rod engagement locations to allow use of the stopper as a replacement with different pre-existing actuating and drain systems when the existing stopper is broken, worn or needs to be replaced for aesthetic reasons. An existing lever rod is selectively positionable to engage with one of the lever rod engagement locations that are disposed at varying heights on the stopper. Most preferably, there are six lever rod engagement locations, four aperture locations and two non-aperture locations. A seal disposed below a cap and around a body of the stopper comprises an enlarged annular ring near its outer edge to provide increased surface area for sealing a drain opening. The body of the stopper has a maximum width measured in cross section of 1.04 inches or less.

Abstract: In one example, a method includes running a downhole system into a downhole environment that comprises a wellbore, and the downhole system is configured such that a reusable plug of the downhole system is positioned uphole of a perforation gun of the downhole system, then, with the perforation gun, perforating a casing at a stage of the wellbore, and the perforating is performed using a projectile, and the perforating is performed by firing the projectile from a chamber of the perforation gun.

Abstract: Provided are chimeric antigen receptors (CARs), which contain antibody portions specific to G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D) and polynucleotides that encode CARs specific for GPRC5D. The disclosure further relates to genetically engineered cells, containing such GPRCSD-binding receptors, and uses thereof in adoptive cell therapy.

Abstract: Provided herein are chimeric receptors, such as chimeric antigen receptors (CARs), comprising BCMA-binding molecules, such as anti-BCMA antibodies and antigen-binding fragments thereof, such as heavy chain variable (VH) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

Abstract: Provided herein are chimeric receptors, such as chimeric antigen receptors (CARs), comprising BCMA-binding molecules, such as anti-BCMA antibodies and antigen-binding fragments thereof, such as heavy chain variable (VH) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

Abstract: The present disclosure relates in some aspects to methods, compositions and uses involving immunotherapies, such as adoptive cell therapy, e.g., T cell therapy, and an immunomodulatory compound, such as a structural or functional analog or derivative of thalidomide and/or an inhibitor of E3-ubiquitin ligase. The provided methods, compositions and uses include those for combination therapies involving the administration or use of one or more immunomodulatory compounds in conjunction with a T cell therapy, such as a genetically engineered T cell therapy involving cells engineered with a recombinant receptor, such as chimeric antigen receptor (CAR)-expressing T cells. Also provided are compositions, methods of administration to subjects, articles of manufacture and kits for use in the methods.

Abstract: Provided are CRIS PR/CAS-related methods, compositions and components for editing a target nucleic acid sequence, or modulating expression of a target nucleic acid sequence, and applications thereof in connection with cancer immunotherapy comprising adoptive transfer of engineered T cells or T cell precursors.

Abstract: A musical instrument includes a soundboard, a bridge in contact with the soundboard, vibratable strings in contact with the bridge, a movable member disposed adjacent to the vibratable strings, a driving mechanism engaged with the movable member and configured to cause the movable member to move relative to the vibratable strings, and actuators. Each actuator is configured to displace, when actuated, an associated vibratable string such that the string is caused to come into contact with the movable member at a point of contact. Displacement of the string corresponds to movement within a first plane that is orthogonal to a second plane, the second plane being tangential to the movable member at the point of contact.

Abstract: A device and method for washing a person's hands includes first and second cleaning agents having an indicator that is visually responsive to interaction of the cleaning agents. The cleaning agents may have different pH characteristics and the indicator is responsive to changes in these pH characteristics as the cleaning agents are mixed together. For example, the indicator may be blue in the presence of an unmixed cleaning agent but turns clear or some other color as the pH changes upon mixing with another cleaning agent. A dispenser includes separated chambers for holding respective cleaning agents, each chamber being associated with a pump and the pumps being associated to simultaneously expel respective cleaning agents. Thus, the cleaning agents may be dispensed onto a user's hands and, when the hands are rubbed together, produce the desired color change as the hands are thoroughly rubbed together.