Abstract: Provided herein are chimeric receptors, such as chimeric antigen receptors (CARs), comprising BCMA-binding molecules, such as anti-BCMA antibodies and antigen-binding fragments thereof, such as heavy chain variable (VH) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

Abstract: A musical instrument includes a soundboard, a bridge in contact with the soundboard, vibratable strings in contact with the bridge, a movable member disposed adjacent to the vibratable strings, a driving mechanism engaged with the movable member and configured to cause the movable member to move relative to the vibratable strings, and actuators. Each actuator is configured to displace, when actuated, an associated vibratable string such that the string is caused to come into contact with the movable member at a point of contact. Displacement of the string corresponds to movement within a first plane that is orthogonal to a second plane, the second plane being tangential to the movable member at the point of contact.

Abstract: A device and method for washing a person's hands includes first and second cleaning agents having an indicator that is visually responsive to interaction of the cleaning agents. The cleaning agents may have different pH characteristics and the indicator is responsive to changes in these pH characteristics as the cleaning agents are mixed together. For example, the indicator may be blue in the presence of an unmixed cleaning agent but turns clear or some other color as the pH changes upon mixing with another cleaning agent. A dispenser includes separated chambers for holding respective cleaning agents, each chamber being associated with a pump and the pumps being associated to simultaneously expel respective cleaning agents. Thus, the cleaning agents may be dispensed onto a user's hands and, when the hands are rubbed together, produce the desired color change as the hands are thoroughly rubbed together.