Abstract: Systems, apparatus, and methods are disclosed for intelligent communication over multiple communications platforms. A dispatch controller interfaces with at least one communication platform to obtain and convert messages to a platform-agnostic format annotated with user and source information. A processing and routing controller applies natural language processing and machine learning techniques to interpret user requests and simultaneously become better at interpreting user requests. A task performance controller invokes specific tasks extracted from routed messages and/or initiates responses to user requests. At least one message bus communicates between the dispatch controller, the processing controller, and the task performance controller, and at least one memory device stores data and processor-executable instructions employed by the dispatch controller, the processing controller, and the task performance controller.

Abstract: State machine methods and apparatus improve computer network functionality relating to natural language communication. In one example, a state machine implements an instance of a workflow to facilitate natural language communication with an entity, and comprises one or more transitions, wherein each transition is triggered by an event and advances the state machine to an outcome state. One or more state machine transitions comprise a work unit that executes one or more computer-related actions relating to natural language communication. An artificial intelligence (AI) agent implements one or more machine learning techniques to monitor inputs/outputs of a given work unit and the respective outcome states of the state machine to determine a status or behavior of the state machine. The AI agent also may generate one or more events to trigger one or more transitions/work units of the state machine, based on one or more inputs monitored by the AI agent and one or more of the machine learning techniques.

Abstract: Systems, apparatus, and methods are disclosed for intelligent communication over multiple communications platforms. A dispatch controller interfaces with at least one communication platform to obtain and convert messages to a platform-agnostic format annotated with user and source information. A processing and routing controller applies natural language processing and machine learning techniques to interpret user requests and simultaneously become better at interpreting user requests. A task performance controller invokes specific tasks extracted from routed messages and/or initiates responses to user requests. At least one message bus communicates between the dispatch controller, the processing controller, and the task performance controller, and at least one memory device stores data and processor-executable instructions employed by the dispatch controller, the processing controller, and the task performance controller.

Abstract: The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers.

Abstract: The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers.

Abstract: Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample.

Abstract: The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers.

Abstract: The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue.

Abstract: The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a biological sample from the subject. The presently-disclosed subject matter further provides methods for determining treatment efficacy and/or progression of a cardiovascular disease in a subject by measuring amounts of one or more of the biomarkers in a biological sample from the subject. The presently-disclosed subject matter also provides antibodies and kits for measuring the biomarkers.

Abstract: Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample.

Abstract: The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue.

Abstract: The present invention relates generally to the electrophoretic separation of biomolecules, including but not limited to proteins, peptides, DNA and RNA. The methods of this invention are particularly useful when applied to two-dimensional gel electrophoresis.

Abstract: The present invention relates generally to the electrophoretic separation of biomolecules, including but not limited to proteins, peptides, DNA and RNA. The methods of this invention are particularly useful when applied to two-dimensional gel electrophoresis.

Abstract: A method and apparatus for supplying power to a computer, and initiating loading of software in the computer in response to a first signal. The invention allows a fax to be received, or a modem session initiated by a computer while the computer is unattended and powered down. The invention initiates the loading of the appropriate software in the computer for conducting the incoming session. The invention also directs incoming calls so that only one phone line is required for voice, fax, and modem sessions.