Patents by Inventor Jon M. Jacobs
Jon M. Jacobs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9651563Abstract: Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.Type: GrantFiled: July 14, 2015Date of Patent: May 16, 2017Assignee: Battelle Memorial InstituteInventors: Jon M. Jacobs, Kristin E. Burnum-Johnson, Erin M. Baker, Richard D. Smith, Marina A. Gritsenko, Daniel Orton
-
Publication number: 20150323551Abstract: Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.Type: ApplicationFiled: July 14, 2015Publication date: November 12, 2015Applicant: Battelle Memorial InstituteInventors: Jon M. Jacobs, Kristin E. Burnum-Johnson, Erin M. Baker, Richard D. Smith, Marina A. Gritsenko, Daniel Orton
-
Patent number: 9134326Abstract: Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.Type: GrantFiled: March 13, 2014Date of Patent: September 15, 2015Assignee: Battelle Memorial InstituteInventors: Jon M. Jacobs, Kristin E. Burnum-Johnson, Erin M. Baker, Richard D. Smith, Marina A. Gritsenko, Daniel Orton
-
Publication number: 20140273275Abstract: Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: BATTELLE MEMORIAL INSTITUTEInventors: JON M. JACOBS, KRISTIN E. BURNUM-JOHNSON, ERIN M. BAKER, RICHARD D. SMITH, MARINA A. GRITSENKO, DANNY ORTON
-
Patent number: 8673644Abstract: A method for identifying persons with increased risk of developing type 2 diabetes mellitus utilizing selected biomarkers described hereafter either alone or in combination. The present invention allows for broad based, reliable, screening of large population bases and provides other advantages, including the formulation of effective strategies for characterizing, archiving, and contrasting data from multiple sample types under varying conditions.Type: GrantFiled: May 13, 2008Date of Patent: March 18, 2014Assignee: Battelle Memorial InstituteInventors: Thomas O. Metz, Wei-Jun Qian, Jon M. Jacobs, Ashoka D. Polpitiya, David G. Camp, II, Richard D. Smith
-
Patent number: 7923253Abstract: A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.Type: GrantFiled: November 5, 2008Date of Patent: April 12, 2011Assignee: Battelle Memorial InstituteInventors: Thomas O Metz, Weijun Qian, Jon M. Jacobs, David G. Camp, II, Richard D. Smith
-
Publication number: 20090286324Abstract: A method for identifying persons with increased risk of developing type 2 diabetes mellitus utilizing selected biomarkers described hereafter either alone or in combination. The present invention allows for broad based, reliable, screening of large population bases and provides other advantages, including the formulation of effective strategies for characterizing, archiving, and contrasting data from multiple sample types under varying conditions.Type: ApplicationFiled: May 13, 2008Publication date: November 19, 2009Inventors: Thomas O. Metz, Wei-Jun Qian, Jon M. Jacobs, Ashoka D. Polpitiya, David G. Camp, II, Richard D. Smith
-
Publication number: 20090117578Abstract: A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.Type: ApplicationFiled: November 5, 2008Publication date: May 7, 2009Inventors: Thomas O. Metz, Weijun Qian, Jon M. Jacobs, David G. Camp, II, Richard D. Smith
-
Patent number: 7179419Abstract: A method for sterilizing medical devices and similar instruments in diffusion-restricted containers is provided. The sterilization method includes placing a liquid solution containing vaporizable germicide such as hydrogen peroxide into the diffusion-restricted container and vaporizing the germicide. The containers can be attachable and detachable to a sterilization system, and used as a vacuum chamber. An attachable/detachable container containing an article to be sterilized can be nested with a second container, and the article and inside and outside of the inner container are sterilized. The sterile article inside the nested containers can be transported and the sterile inner container with the sterilized article can removed from the outer container and placed in a sterile environment without contaminating the sterile environment. The sterile article can then be removed from the sterile container and utilized.Type: GrantFiled: October 31, 2002Date of Patent: February 20, 2007Assignee: Johnson & Johnson Medical Div Ethicon, Inc.Inventors: Szu-Min Lin, Anthony Lemus, Harold R. Williams, Paul T. Jacobs, Tralance O. Addy, Jon M. Jacobs
-
Publication number: 20030206827Abstract: A method for sterilizing medical devices and similar instruments in diffusion-restricted containers is provided. The sterilization method includes placing a liquid solution containing vaporizable germicide such as hydrogen peroxide into the diffusion-restricted container and vaporizing the germicide. The containers can be attachable and detachable to a sterilization system, and used as a vacuum chamber. An attachable/detachable container containing an article to be sterilized can be nested with a second container, and the article and inside and outside of the inner container are sterilized. The sterile article inside the nested containers can be transported and the sterile inner container with the sterilized article can removed from the outer container and placed in a sterile environment without contaminating the sterile environment. The sterile article can then be removed from the sterile container and utilized.Type: ApplicationFiled: October 31, 2002Publication date: November 6, 2003Inventors: Szu-Min Lin, Anthony Lemus, Harold R. Williams, Paul T. Jacobs, Tralance O. Addy, Jon M. Jacobs