Abstract: Systems and methods for remotely monitoring the amount of fuel in one or more fuel tanks are disclosed. A fuel monitoring device includes a sensor configured to monitor the operation of a valve coupled to an output of a fuel tank and a network and communication system configured to receive data from the sensor related to the operation of the valve and establish communication with one or more remote systems via a communications network. The fuel monitoring device communicates the data related to the operation of the sensor to a remote server system via the communications network. Based on the data received from the fuel monitoring device and one or more remote systems, the remote server system can determine the amount of fuel remaining in the tank, and can predict when the tank will require additional fuel.

Abstract: A hand-held device (2) for applying a barrier material (4, 6) to a lock of hair to be treated with a highlighting composition (32) is disclosed. The device may comprise one or two rolls (8, 10) of a tape of barrier material (4, 6) that is dispensed to the lock of hair as the same time as the roll or rolls (8, 10) are unrolled. The device may also contain the highlighting composition (32), either applied on the rolled tape or via a reservoir contained in the body.

Abstract: A hand-held device (2) for applying a barrier material (4, 6) to a lock of hair to be treated with a highlighting composition (32) is disclosed. The device may comprise one or two rolls (8, 10) of a tape of barrier material (4, 6) that is dispensed to the lock of hair as the same time as the roll or rolls (8, 10) are unrolled. The device may also contain the highlighting composition (32), either applied on the rolled tape or via a reservoir contained in the body.

Abstract: Disclosed is a vaccine against Lyme Disease or its causative agent Borrelia burgdorferi (sensu stricto or sensu lato) containing a plasmid a DNA encoding a promoter for driving expression in a mammalian cell, DNA encoding a leader peptide for facilitating secretion/release of a prokaryotic protein sequence from a mammalian cell, a DNA encoding Borrelia OspA or OspB, and a DNA encoding a terminator. Disclosed too is an immunogenic composition against Lyme Disease or its causative agent Borrelia burgdorferi (sensu stricto or sensu lato) containing a plasmid comprising a DNA encoding a promoter for driving expression in a mammalian cell, DNA encoding a leader peptide for facilitating secretion/release of a prokaryotic protein sequence from a mammalian cell, a DNA encoding a Borrelia OspC, and a DNA encoding a terminator. And, methods for making and using such vaccines and the immunogenic composition are also disclosed.

Abstract: Plasmid DNA encoding at least one Borrelia genospecies antigen and methods for making and using such a plasmid are disclosed and claimed. The genospecies can be burgdorferi, garinii and/or afzelli. The antigen can be OspA and/or OspB and/or OspC. Compositions containing the plasmid DNA are useful for administration to a host susceptible to Lyme Disease for an in vivo response, such as a protective response, or for generating useful antibodies. The inventive plasmid can also be transfected into cells for generating antigens in vitro. And, the inventive plasmid can be prepared by isolating DNA (such as DNA coding for: promoter, leader sequence, antigen, and terminator) and performing a ligation or ligations, such as a three-way ligation. More particularly, administration of DNA encoding Borrelia genospecies antigen, e.g.

Abstract: Disclosed are the compounds of the formula ##STR1## wherein n represents the integer 1,2,3 or 4; R.sub.1 represents hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy or lower alkoxy; R.sub.2 represents hydrogen or lower alkyl; R.sub.3 represents hydrogen, lower alkyl or halogen; R.sub.4 represents amino, lower alkylamino, di-lower alkylamino, morpholino, N-lower alkyl or N-aryl piperazino, pyrrolidino, piperidino or substituted piperidino selected from ##STR2## in which R.sub.5 represents hydrogen, halogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful in mammals as calmodulin antagonists for the treatments of gastrointestinal disorders.