Patents by Inventor Jon P. Anderson
Jon P. Anderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9809842Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.Type: GrantFiled: March 24, 2014Date of Patent: November 7, 2017Assignee: LI-COR, Inc.Inventors: Ahmed Bouzid, Chris Lesiak, Daniel W. Konz, David L. Franzen, William Biggs, Jon P. Anderson
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Patent number: 9595430Abstract: A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (MALDI) for use with a mass spectrometer. The nanoparticles can be coated with polymers that activate to immobilize the analytes or assist with MALDI. The separation can occur in two dimensions.Type: GrantFiled: March 25, 2015Date of Patent: March 14, 2017Assignees: LI-COR, INC., Purdue Research FoundationInventors: Michael D. Furtaw, Jon P. Anderson, Mary J. Wirth, Robert E. Birdsall, Yimin Hua, Zhaorui Zhang
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Publication number: 20150279648Abstract: A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (MALDI) for use with a mass spectrometer. The nanoparticles can be coated with polymers that activate to immobilize the analytes or assist with MALDI. The separation can occur in two dimensions.Type: ApplicationFiled: March 25, 2015Publication date: October 1, 2015Applicants: LI-COR, Inc., Purdue Research FoundationInventors: Michael D. Furtaw, Jon P. Anderson, Mary J. Wirth, Robert E. Birdsall, Yimin Hua, Zhaorui Zhang
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Publication number: 20150276674Abstract: The present invention provides systems, methods and kits which enable or utilize an immunologically-based assay, such as a Western immunoassay, to separate, detect or to monitor an analyte or a mixture of analytes such as biomolecules.Type: ApplicationFiled: March 25, 2015Publication date: October 1, 2015Applicants: LI-COR, INC., PURDUE RESEARCH FOUNDATIONInventors: Michael D. Furtaw, Jon P. Anderson, Mary J. Wirth, Robert Birdsall, Yimin Hua, Pei-Hsun Wei
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Patent number: 9045798Abstract: The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for sequencing a nucleic acid comprising immobilizing a plurality of complexes comprising a target nucleic acid, a primer nucleic acid, and a polymerase onto a surface, contacting the surface with a plurality of charged particles comprising a nucleotide phosphate by applying an electric field, reversing the electric field to transport unbound charged particles away from the surface, and detecting the incorporation of a nucleotide phosphate into a single molecule of the primer nucleic acid.Type: GrantFiled: March 15, 2006Date of Patent: June 2, 2015Assignee: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.Inventors: John G. K. Williams, Jon P. Anderson
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Publication number: 20150086994Abstract: The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for sequencing a nucleic acid comprising immobilizing a plurality of complexes comprising a target nucleic acid, a primer nucleic acid, and a polymerase onto a surface, contacting the surface with a plurality of charged particles comprising a nucleotide phosphate by applying an electric field, reversing the electric field to transport unbound charged particles away from the surface, and detecting the incorporation of a nucleotide phosphate into a single molecule of the primer nucleic acid.Type: ApplicationFiled: October 7, 2014Publication date: March 26, 2015Inventors: John G. K. Williams, Jon P. Anderson
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Publication number: 20140206568Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.Type: ApplicationFiled: March 24, 2014Publication date: July 24, 2014Applicant: LI-COR, Inc.Inventors: Ahmed Bouzid, Chris Lesiak, Daniel W. Konz, David L. Franzen, William Biggs, Jon P. Anderson
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Patent number: 8722346Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.Type: GrantFiled: June 17, 2013Date of Patent: May 13, 2014Assignee: Li-Cor, Inc.Inventors: Ahmed Bouzid, Chris Lesiak, Daniel W. Konz, David L. Franzen, William Biggs, Jon P. Anderson
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Patent number: 8592148Abstract: The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for sequencing a nucleic acid comprising immobilizing a plurality of complexes comprising a target nucleic acid, a primer nucleic acid, and a polymerase onto a surface, contacting the surface with a plurality of charged particles comprising a nucleotide phosphate by applying an electric field, reversing the electric field to transport unbound charged particles away from the surface, and detecting the incorporation of a nucleotide phosphate into a single molecule of the primer nucleic acid.Type: GrantFiled: October 31, 2008Date of Patent: November 26, 2013Assignee: Pacific Biosciences of CaliforniaInventors: John G. K. Williams, Jon P. Anderson
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Publication number: 20130280737Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.Type: ApplicationFiled: June 17, 2013Publication date: October 24, 2013Applicant: Li-Cor, Inc.Inventors: Ahmed Bouzid, Chris Lesiak, Daniel W. Konz, David L. Franzen, William Biggs, Jon P. Anderson
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Patent number: 8486644Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.Type: GrantFiled: March 28, 2012Date of Patent: July 16, 2013Assignee: Li-Cor, Inc.Inventors: Ahmed Bouzid, Chris Lesiak, Daniel W. Konz, David L. Franzen, William Biggs, Jon P. Anderson
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Publication number: 20130157282Abstract: Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.Type: ApplicationFiled: March 28, 2012Publication date: June 20, 2013Applicant: Li-Cor, Inc.Inventors: Ahmed Bouzid, Chris Lesiak, Daniel W. Konz, David L. Franzen, William Biggs, Jon P. Anderson
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Publication number: 20110177496Abstract: The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for sequencing a nucleic acid comprising immobilizing a plurality of complexes comprising a target nucleic acid, a primer nucleic acid, and a polymerase onto a surface, contacting the surface with a plurality of charged particles comprising a nucleotide phosphate by applying an electric field, reversing the electric field to transport unbound charged particles away from the surface, and detecting the incorporation of a nucleotide phosphate into a single molecule of the primer nucleic acid.Type: ApplicationFiled: October 31, 2008Publication date: July 21, 2011Applicant: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.Inventors: JOHN G.K. WILLIAMS, JON P. ANDERSON
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Publication number: 20090092966Abstract: Metal colloidal aggregates substrates useful for metal enhanced fluorescence applications, are disclosed. Method of making and using these colloidal aggregates for enhancing the fluorescent signal in biological assays are also described.Type: ApplicationFiled: May 30, 2007Publication date: April 9, 2009Applicant: LI-COR, Inc.Inventors: Jon P. Anderson, Teresa M. Urlacher
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Patent number: 7462452Abstract: The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for sequencing a nucleic acid comprising immobilizing a plurality of complexes comprising a target nucleic acid, a primer nucleic acid, and a polymerase onto a surface, contacting the surface with a plurality of charged particles comprising a nucleotide phosphate by applying an electric field, reversing the electric field to transport unbound charged particles away from the surface, and detecting the incorporation of a nucleotide phosphate into a single molecule of the primer nucleic acid.Type: GrantFiled: April 29, 2005Date of Patent: December 9, 2008Assignee: Pacific Biosciences of California, Inc.Inventors: John G. K. Williams, Jon P. Anderson