Abstract: Disclosed herein are compositions, systems, and methods relating to three-dimensional bioprinted tissue models, in particular liver tissue modes. Compositions, systems, and methods as described here provide for improved tissue models, thereby improving their utility for diagnostic, clinical, and research purposes. In certain aspects, tissue models as described herein exhibit gene expression profiles, enzymatic function, and enzyme/protein secretion comparable to in vivo organs.

Abstract: Perfusion systems compatible with 12- and 96-well plates well plates are provided. The system includes a chamber insert and a reservoir lid that couple together to fit the well plate. Each well receives an insert with compartments for media supply compartment and media collection to service media in the well. The reservoir lid includes a media supply well and a media collection port. When the system is assembled, the media supply well is in fluid communication with the media supply compartment and the media collection port is in fluid communication with the media collection compartment.

Abstract: Embodiments of the present disclosure include separating devices and systems and methods of use. Embodiments of the present disclosure include separation devices including magnetic arrays and sheet-flow separation chambers. In an embodiment, the separating device enables the generation of multiple, and in some configurations, intersecting, high gradient magnetic field lines, resulting in strong separation forces, which permit for scale up to large areas and/or volumes (e.g., extracorporeal blood filtration system).

Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.

Abstract: In one aspect, the disclosure relates to a support material for 3D printing of soft materials having feature sizes <5 µm that persist over time, methods of 3D printing using the same, and articles that include soft matter constructed using the disclosed methods. In one aspect, the support materials can be jammed inverse emulsions having silicone oils as the continuous phase and glycerol/water mixtures as the dispersed phase. In some aspects, the support materials also include a surfactant. In any of these aspects, the support materials can be optically clear.

Abstract: The present disclosure includes composite microparticles for magnetically triggered release of a biologically active agent. Also included are systems including the biocompatible composite microparticles and an alternating current (AC) magnetic field generator to magnetically trigger release of a biologically active agent from the microparticles. The present disclosure further includes methods of delivering a biologically active agent to a patient in vivo using the microparticles and systems of the present disclosure. The present disclosure also includes methods of making biocompatible composite microparticles of the present disclosure for magnetically triggered release of a biologically active agent.

Abstract: Embodiments of the present disclosure include separating devices and systems and methods of use. Embodiments of the present disclosure include separation devices including magnetic arrays and sheet-flow separation chambers. In an embodiment, the separating device enables the generation of multiple, and in some configurations, intersecting, high gradient magnetic field lines, resulting in strong separation forces, which permit for scale up to large areas and/or volumes (e.g., extracorporeal blood filtration system).

Abstract: Provided herein is a liposome comprising ribonucleic acid (RNA) molecules, a lipid mixture comprising DOTAP and cholesterol, and iron oxide nanoparticles (IONPs). Also provided herein is a liposome comprising ribonucleic acid (RNA) molecules and a lipid mixture comprising DOTAP and cholesterol, wherein the DOTAP and cholesterol are present in the lipid mixture at a DOTAP:cholesterol ratio of about 3:1 by mass. Related cells comprising the liposome, populations of cells, and compositions are also provided. Methods of making a liposome and methods of using the liposome are further provided.

Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.

Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.

Abstract: Embodiments of the present disclosure provide for polymer conjugates, methods of making the polymer conjugates, methods of using polymer conjugates, and the like, where the polymer conjugates include magnetic particles (e.g. iron oxide particles). Embodiments of the present disclosure can be advantageous for one or more of the following reasons: strong and rapid magnetic response, multiple types of agents can be attached to the polymer conjugate, the size of the polymer conjugate can be controlled, and the polymer conjugates can be produced in a cost-effective manner.

Abstract: Embodiments of the present disclosure include separating devices and systems and methods of use. Embodiments of the present disclosure include separation devices including magnetic arrays and sheet-flow separation chambers. In an embodiment, the separating device enables the generation of multiple, and in some configurations, intersecting, high gradient magnetic field lines, resulting in strong separation forces, which permits for scale up to large areas and/or volumes (e.g., extracorporeal blood filtration system).

Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.

Abstract: TGF-? growth factor and its latent complex are conjugated to magnetic micro- or nanoparticles and to magnetic micro- or nanodiscs. By exposing the resulting conjugates to magnetic fields, the TGF-? growth factor can be released from its latent complex in vivo, potentially making it useful in tissue engineering and regenerative medicine. And by exposing a conjugate of TGF-? growth factor and a magnetic particle to a sufficiently strong, radiofrequency magnetic field, the TGF-? growth factor can be denatured and thereby deactivated, potentially making it possible to avoid triggering tumorigenesis, atherosclerosis, fibrotic disease, and cancer.

Abstract: TGF-? growth factor and its latent complex are conjugated to magnetic micro- or nanoparticles and to magnetic micro- or nanodiscs. By exposing the resulting conjugates to magnetic fields, the TGF-? growth factor can be released from its latent complex in vivo, potentially making it useful in tissue engineering and regenerative medicine. And by exposing a conjugate of TGF-? growth factor and a magnetic particle to a sufficiently strong, radiofrequency magnetic field, the TGF-? growth factor can be denatured and thereby deactivated, potentially making it possible to avoid triggering tumorigenesis, atherosclerosis, fibrotic disease, and cancer.