Patents by Inventor Jon R. Appel, Jr.

Jon R. Appel, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5556762
    Abstract: Synthetic peptide combinatorial libraries (sets) having a single, predetermined amino acid residue at a single, predetermined oligopeptide chain position and mixtures of amino acid residues at the other chain positions are disclosed, as are their processes of synthesis and use in determining the amino acid residue sequence of an oligopeptide ligand that binds to an acceptor molecule.
    Type: Grant
    Filed: September 11, 1992
    Date of Patent: September 17, 1996
    Assignee: Houghten Pharmaceutical Inc.
    Inventors: Clemencia Pinilla, Jon R. Appel, Jr., Richard A. Houghten
  • Patent number: 5504190
    Abstract: A process for the synthesis of a complex mixture pool of solid support-coupled monomeric repeating unit compounds such as amino acid derivatives is disclosed in which the mixture pool contains an equimolar representation of reacted monomeric repeating unit compounds coupled. Also disclosed is a process for the stepwise synthesis of a complex mixture of coupled or free, unsupported oligomers such as oligopeptides. A set of self-solubilizing, unsupported mixed oligopeptides having one or more predetermined amino acid residues at one or more of the same, predetermined positions in the oligopeptide chain in which the set contains equimolar amounts of a plurality of different amino acid residues, preferably at least six different residues, at one or more of the same predetermined positions of the oligopeptide chain is also disclosed, as are methods of making and using the same.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: April 2, 1996
    Assignee: Torrey Pines Institute for Molecular Studies
    Inventors: Richard A. Houghten, Julio H. Cuervo, Clemencia Pinilla, Jon R. Appel, Jr., Silvie Blondelle