Patents by Inventor Jon R. Rosar

Jon R. Rosar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Manufacture and Use of Implantable Pressure-Actuated Drug Delivery Systems
    Publication number: 20140188213
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Application
    Filed: February 13, 2014
    Publication date: July 3, 2014
    Applicant: Johns Hopkins University
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Rosar, Robert C. Matteson, George L/ Coles, Jason J. Benkoski, Morgana M. Trexler
  • Implantable pressure-actuated drug delivery systems and methods of manufacture and use
    Patent number: 8696740
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: April 15, 2014
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Rosar, Robert C. Matteson, III, George L. Coles, Jr., Jason J. Benkoski, Morgana M. Trexler
  • Implantable Pressure-Actuated Drug Delivery Systems and Methods of Manufacture and Use
    Publication number: 20120010698
    Abstract: Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.
    Type: Application
    Filed: January 5, 2011
    Publication date: January 12, 2012
    Inventors: Chao-Wei Hwang, Hala J. Tomey, Jon R. Rosar, Robert C. Matteson, III, George L. Coles, JR., Jason J. Benkoski, Morgana M. Trexler