Patents by Inventor Jon Roffey

Jon Roffey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT
    Publication number: 20230183197
    Abstract: The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: wherein R1, R2, R3, R4, R6 and R10 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which MLH1 and/or PMS2 activity is implicated.
    Type: Application
    Filed: June 1, 2020
    Publication date: June 15, 2023
    Inventors: Julian Blagg, Jon Roffey, Martin Drysdale, Paul Winship, David Clark