Abstract: A lithotripsy device includes an elongate body comprising a distal tip portion having an end surface that forms a non-zero angle with a longitudinal axis of the elongate body, a balloon circumferentially around a portion of the elongate body enclosing the end surface of the tip portion defining an interior configured to receive a fluid, and at least one emitter positioned at the end surface of the tip portion of the elongate body. The at least one emitter is configured to generate pressure waves in the fluid propagating through the balloon to disintegrate a calcified lesion. A method of using a lithotripsy device is also provided.

Abstract: An intravascular device includes a tube member. The tube member comprises a distal portion and a proximal portion. Each of the distal portion and the proximal portion of the tube member comprises a plurality of cuts circumferentially extending around a longitudinal axis of the tube member. The plurality of cuts of the distal portion of the tube member comprises a first pitch, a first cut length, and a first uncut length, the plurality of cuts of the proximal portion of the tube member comprises a second pitch, a second cut length, and a second uncut length, and the first pitch is less than the second pitch, the first cut length is greater than the second length, and the first uncut length is less than the second uncut length.

Abstract: A thrombectomy device includes a coring member configured to disintegrate a thrombus in a vessel into fragments from a proximal side of the thrombus and a catch member configured to be anchored at a distal side of the thrombus to provide embolic protection. The coring member and the catch member are operable independently of each other. Methods of removing a thrombus from a vessel employ a rotating coring device to disintegrate the thrombus into fragments.

Abstract: A lithotripsy device includes an elongate body comprising a distal tip portion having an end surface that forms a non-zero angle with a longitudinal axis of the elongate body, a balloon circumferentially around a portion of the elongate body enclosing the end surface of the tip portion defining an interior configured to receive a fluid, and at least one emitter positioned at the end surface of the tip portion of the elongate body. The at least one emitter is configured to generate pressure waves in the fluid propagating through the balloon to disintegrate a calcified lesion. A method of using a lithotripsy device is also provided.

Abstract: A guidewire device includes an elongate core wire and a tube member over the distal section of the elongate core wire. The tube member comprises a plurality of transverse cuts at a plurality of axial locations of the tube member, forming a plurality of circumferentially extending rings joined by a plurality of beams. The plurality of transverse cuts comprises a tapered geometry with a cut width at the outer surface of the tube member being greater than a cut width at the inner surface of the tube member.

Abstract: A balloon catheter includes a tubular body and a balloon circumferentially around a portion of the tubular body. The tubular body includes an outer surface and an inner surface defining a lumen of the tubular body. The balloon comprises a proximal end portion and a distal end portion each being secured to the tubular body, and a distensible portion defining an interior that is in fluid communication with the lumen of the tubular body. The distal end portion of the balloon extends through the outer surface and the inner surface into the lumen of the tubular body, forming a sealing portion circumferentially around the inner surface of the tubular body. A catheter assembly including a balloon catheter and a method of use are also provided.

Abstract: A guidewire device includes an elongate core wire and a tube member over the distal section of the elongate core wire. The tube member comprises a plurality of transverse cuts at a plurality of axial locations of the tube member, forming a plurality of circumferentially extending rings joined by a plurality of beams. The plurality of transverse cuts comprises a tapered geometry with a cut width at the outer surface of the tube member being greater than a cut width at the inner surface of the tube member.

Abstract: An intravascular device includes a tube member. The tube member comprises a distal portion and a proximal portion. Each of the distal portion and the proximal portion of the tube member comprises a plurality of cuts circumferentially extending around a longitudinal axis of the tube member. The plurality of cuts of the distal portion of the tube member comprises a first pitch, a first cut length, and a first uncut length, the plurality of cuts of the proximal portion of the tube member comprises a second pitch, a second cut length, and a second uncut length, and the first pitch is less than the second pitch, the first cut length is greater than the second length, and the first uncut length is less than the second uncut length.

Abstract: An endovascular system includes a delivery device operable to deliver a tubular implant through a catheter. The delivery device comprises a delivery wire, a set of stoppers comprising a distal stopper and a proximal stopper fixedly attached to the delivery wire, a coupler disposed between the distal stopper and the proximal stopper, and a protection cover wrapping at least an end portion of the tubular implant. A method of delivering a tubular implant is also described.

Abstract: A guidewire device employs an expandable structure or a plurality of disks to center a core wire to improve torque transmission control. Also disclosed are a guidewire device including a radiopaque coil or braid constructed of two or more different materials to improve the shapeability and shape retention of the device, and a guidewire device including an indicator to provide a visual indication of changes of the stiffness profile of the device to assist the physician during the clinical use. A guidewire device including a core wire constructed from a metal composite wire to provide for more manufacturing options through various combinations of the metal composite wire inner core and outer sheath and/or through adjusting the metal composite wire inner core fill percentage is also disclosed.

Abstract: An intravascular device includes a tube member. The tube member comprises a distal portion and a proximal portion. Each of the distal portion and the proximal portion of the tube member comprises a plurality of cuts circumferentially extending around a longitudinal axis of the tube member. The plurality of cuts of the distal portion of the tube member comprises a first pitch, a first cut length, and a first uncut length, the plurality of cuts of the proximal portion of the tube member comprises a second pitch, a second cut length, and a second uncut length, and the first pitch is less than the second pitch, the first cut length is greater than the second length, and the first uncut length is less than the second uncut length.

Abstract: A catheter device includes a tube member. The tube member comprises a distal portion and a proximal portion. Each of the distal portion and the proximal portion of the tube member comprises a plurality of cuts circumferentially extending around a longitudinal axis of the tube member. The plurality of cuts of the distal portion of the tube member comprises a first pitch, a first cut length, and a first uncut length, the plurality of cuts of the proximal portion of the tube member comprises a second pitch, a second cut length, and a second uncut length, and the first pitch is less than the second pitch, the first cut length is greater than the second length, and the first uncut length is less than the second uncut length.

Abstract: A guidewire device includes an elongate core wire and a tube member over the distal section of the elongate core wire. The tube member comprises a plurality of transverse cuts at a plurality of axial locations of the tube member, forming a plurality of circumferentially extending rings joined by a plurality of beams. The plurality of transverse cuts comprises a tapered geometry with a cut width at the outer surface of the tube member being greater than a cut width at the inner surface of the tube member.

Abstract: An endovascular system includes a delivery device operable to advance and/or retract a tubular implant disposed in the lumen of a catheter. The delivery device comprises a delivery wire, a set of stoppers comprising a distal stopper and a proximal stopper fixedly attached to the delivery wire, and a coupler disposed between the distal stopper and the proximal stopper of the set. The coupler is configured to contact and apply an outwardly radial force to a distal end portion of the tubular implant in the lumen of the catheter to grip the tubular implant in the lumen of the catheter. The proximal stopper of the set is configured to engage the coupler when the delivery wire is advanced to apply a translating force in a distal direction to the coupler thereby generating a pulling force in the distal direction on a portion of the tubular implant proximal of the distal end portion of the tubular implant.

Abstract: A thrombectomy device includes a coring member configured to disintegrate a thrombus in a vessel into fragments from a proximal side of the thrombus and a catch member configured to be anchored at a distal side of the thrombus to provide embolic protection. The coring member and the catch member are operable independently of each other. Methods of removing a thrombus from a vessel employ a rotating coring device to disintegrate the thrombus into fragments.

Abstract: A lithotripsy device includes an elongate body comprising a distal tip portion having an end surface that forms a non-zero angle with a longitudinal axis of the elongate body, a balloon circumferentially around a portion of the elongate body enclosing the end surface of the tip portion defining an interior configured to receive a fluid, and at least one emitter positioned at the end surface of the tip portion of the elongate body. The at least one emitter is configured to generate pressure waves in the fluid propagating through the balloon to disintegrate a calcified lesion. A method of using a lithotripsy device is also provided.

Abstract: An occlusion device includes a braided mesh body and at least one pinch member. The braided mesh body comprises plural strands each having a first end portion and a second end portion. The plural strands fold over to bring the second end portions of the plural strands adjacent to the first end portions of the plural strands forming a double-layer of the braided mesh body. In an example occlusion device, at least one of the plural strands is radiopaque, and the at least one pinch member is non-radiopaque.

Abstract: A balloon catheter includes a tubular body and a balloon circumferentially around a portion of the tubular body. The tubular body includes an outer surface and an inner surface defining a lumen of the tubular body. The balloon comprises a proximal end portion and a distal end portion each being secured to the tubular body, and a distensible portion defining an interior that is in fluid communication with the lumen of the tubular body. The distal end portion of the balloon extends through the outer surface and the inner surface into the lumen of the tubular body, forming a sealing portion circumferentially around the inner surface of the tubular body. A catheter assembly including a balloon catheter and a method of use are also provided.

Abstract: An endovascular system includes an implant and a delivery system configured to deliver and deploy the implant to a treatment site in a vessel. The implant is radially expandable and configured to be deployed in vessels with diameters ranging from a minimal diameter to a maximal diameter. The delivery system comprises a proximal landing zone indicator comprising a radiopaque marker having a length from a proximal end to a distal end of the radiopaque marker, wherein the proximal end of the radiopaque marker indicates a position of the proximal end of the implant if deployed at a treatment site in a vessel having the minimal diameter, and the distal end of the radiopaque marker indicates a position of the proximal end of the implant if deployed at a treatment site in a vessel having the maximal diameter. A method of delivering an expandable implant to a target site in a patient's vascular system is also disclosed.

Abstract: A catheter includes an elongate tubular body having a side wall defining a lumen extending between a proximal region and a distal region. The distal region comprises a tip portion capable of deflecting away from the proximal region when the tip portion is unconstrained, thereby forming a curved shape of the tip portion. The side wall of the elongate tubular body axially terminates at the tip portion with a slant cut, thereby forming an end surface of the tip portion defining an opening in a non-circular shape.