Patents by Inventor Jon T. Holmlund

Jon T. Holmlund has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pulsatile Dosing of Gossypol for Treatment of Disease
    Publication number: 20100189683
    Abstract: This invention relates to pulsatile dose administration of gossypol or pharmaceutical compositions thereof for treating diseases, disorders and conditions responsive to gossypol, inhibiting the activity of anti-apoptotic Bcl-2 family proteins, inducing apoptosis in cells and increasing the sensitivity of cells to inducers of apoptosis.
    Type: Application
    Filed: December 10, 2009
    Publication date: July 29, 2010
    Applicant: Ascenta Therapeutics, Inc.
    Inventors: Jon T. Holmlund, Mel Sorensen, Lance Leopold, Dajun Yang
  • Pulsatile Dosing of Gossypol for Treatment of Disease
    Publication number: 20090175869
    Abstract: This invention relates to pulsatile dose administration of gossypol, a gossypol-related compound or pharmaceutical compositions thereof for treating diseases, disorders and conditions responsive to gossypol or gossypol-related compound, inhibiting the activity of anti-apoptotic Bcl-2 family proteins, inducing apoptosis in cells and increasing the sensitivity of cells to inducers of apoptosis.
    Type: Application
    Filed: December 10, 2008
    Publication date: July 9, 2009
    Applicant: Ascenta Therapeutics, Inc.
    Inventors: Jon T. Holmlund, Mel Sorensen, Lance Leopold, Dajun Yang
  • Pulsatile dosing of gossypol for treatment of disease
    Publication number: 20090010878
    Abstract: This invention relates to pulsatile dose administration of gossypol or pharmaceutical compositions thereof for treating diseases, disorders and conditions responsive to gossypol, inhibiting the activity of anti-apoptotic Bcl-2 family proteins, inducing apoptosis in cells and increasing the sensitivity of cells to inducers of apoptosis.
    Type: Application
    Filed: June 2, 2008
    Publication date: January 8, 2009
    Applicant: Ascenta Therapeutics, Inc.
    Inventors: Jon T. Holmlund, Mel Sorensen, Lance Leopold, Dajun Yang
  • Oligonucleotide inhibition of protein kinase C
    Publication number: 20030148989
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
    Type: Application
    Filed: January 21, 2003
    Publication date: August 7, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: C. Frank Bennett, Nicholas M. Dean, Jon T. Holmlund, F. Andrew Dorr
  • Oligonucleotide inhibition of protein kinase C
    Patent number: 6537973
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: March 25, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: C. Frank Bennett, Nicholas M. Dean, Jon T. Holmlund, F. Andrew Dorr