Patents by Inventor Jon W. Weeks

Jon W. Weeks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pore-modified gram-negative bacteria and uses thereof
    Patent number: 11021521
    Abstract: Mutants of Gram-negative bacteria having outer membranes comprising modified OrbA nanopores absent an N-terminal plug domain are disclosed. The modified OrbA nanopores confer the outer membrane of the bacteria with enhanced permeability. The mutants of Gram-negative bacteria optionally comprise efflux-deficient efflux pumps. The mutants may be used, for example, in a screening method for identifying a compound having an anti-bacterial activity.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: June 1, 2021
    Assignee: THE BOARD OR REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventors: Helen Zgurskaya, Jon W. Weeks
  • PORE-MODIFIED GRAM-NEGATIVE BACTERIA AND USES THEREOF
    Publication number: 20190002508
    Abstract: Mutants of Gram-negative bacteria having outer membranes comprising modified OrbA nanopores absent an N-terminal plug domain are disclosed. The modified OrbA nanopores confer the outer membrane of the bacteria with enhanced permeability. The mutants of Gram-negative bacteria optionally comprise efflux-deficient efflux pumps. The mutants may be used, for example, in a screening method for identifying a compound having an anti-bacterial activity.
    Type: Application
    Filed: September 18, 2018
    Publication date: January 3, 2019
    Inventors: Helen Zgurskaya, Jon W. Weeks