Patents by Inventor JON WINTER-HOLT

JON WINTER-HOLT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLQ inhibitors
    Patent number: 12653828
    Abstract: The specification generally relates to compounds of Formula (I): or a stereoisomer or pharmaceutically salt thereof, wherein G, Ga, Gb, X, Y, R1, R2, Q1, Q2, and Q3 have any of the meanings defined herein, together with compositions containing them and their use in therapy. The compounds are inhibitors of the polymerase, DNA polymerase theta (Pol? or POLQ), and are thereby particularly useful in the treatment of cancer.
    Type: Grant
    Filed: December 5, 2023
    Date of Patent: June 16, 2026
    Assignee: ASTRAZENECA AB
    Inventors: Bernard Barlaam, Michael Bodnarchuk, Gail Wrigley, Jon Winter-Holt, Oliver Turner, Ariamala Gopalsamy, Jason Shields, Sofia Ferrer Cabrera, Helen Elizabeth Jones
  • POLQ INHIBITORS
    Publication number: 20240366615
    Abstract: The specification generally relates to compounds of Formula (I): or a stereoisomer or pharmaceutically salt thereof, wherein G, Ga, Gb, X, Y, R1, R2, Q1, Q2, and Q3 have any of the meanings defined herein, together with compositions containing them and their use in therapy. The compounds are inhibitors of the polymerase, DNA polymerase theta (Pol? or POLQ), and are thereby particularly useful in the treatment of cancer.
    Type: Application
    Filed: December 5, 2023
    Publication date: November 7, 2024
    Inventors: BERNARD BARLAAM, MICHAEL BODNARCHUK, GAIL WRIGLEY, JON WINTER-HOLT, OLIVER TURNER, ARIAMALA GOPALSAMY, JASON SHIELDS, SOFIA FERRER CABRERA