Abstract: An antibody specifically binding to TIGIT or an antigen-binding fragment thereof can effectively block the binding of TIGIT to a ligand thereof and release the inhibitory effect of the ligand of TIGIT on a downstream signal of TIGIT. The present invention further relates to a composition containing the antibody or antigen-binding fragment thereof, a nucleic acid coding the antibody or the antigen-binding fragment thereof, a host cell containing the nucleic acid, and a related use. In addition, the present invention also relates to treatment and diagnosis uses of the antibody or the antigen-binding fragment thereof.

Abstract: A computing device may receive, from a remote computing device, a request to establish a communication session with the remote computing device and contextual information indicative of an urgency level of the communication session. The computing device may output, at one or more output devices, the contextual information indicative of the urgency level of the communication session and at least one of: haptic output or an audible alert that indicates the request to establish the communication session.

Abstract: A method of calibrating an ultrasonic characteristic on a wire bonding system is provided. The method includes the steps of: (a) determining a reference ultrasonic characteristic for formation of a wire bond; (b) determining a reference non-stick ultrasonic characteristic that results in a non-stick wire bond condition; (c) determining a calibration non-stick ultrasonic characteristic, on a wire bonding system to be calibrated, that results in a non-stick wire bond condition; and (d) determining a calibration factor for the wire bonding system to be calibrated using the reference non-stick ultrasonic characteristic and the calibration non-stick ultrasonic characteristic.

Abstract: A pedestal leg assembly includes a pedestal leg and floor base. The leg includes a plurality of teeth near the bottom end of the leg and a connecting bolt in a threaded engagement with the bottom end of the leg. The floor base includes a recessed portion having a slot in its bottom surface to receive the bolt and a release mechanism configured to pivot between a lock position and a release position. In lock position the release mechanism engages at least one of the teeth to prevent rotation of the pedestal leg in at least one direction. When pivoted into release position, the release mechanism is moved away from engagement with the teeth to allow rotation of the pedestal leg in both clockwise and counterclockwise directions. The pedestal leg assembly may include a powered connection to receive input power and/or a communication signal at the floor base and transfer the power and communication signals to a supported table top surface.

Abstract: The invention relates to the targeted delivery of therapeutic molecules to organs, tissues, and cells of humans and other mammals. The invention is directed to a chemical construct for delivering such therapeutic molecules and to methods of making and using the constructs.

Abstract: The present invention provides a method and system for providing a mobile device with a selected subset of global address list (GAL) contacts. The offline GAL contacts stored on the device are in sync with the master corporate GAL. The GAL contacts are automatically selected based on the user's emails or meetings and are not duplicates of the contacts within the user's personal contact list. The GAL contacts are browsed and searched seamlessly with the user's other contacts.

Abstract: A system for data communication is disclosed. The system comprises a detection module that ascertains when a mobile wireless communication device is located within a first range of a data source. The system further comprises a data module that automatically sends information to the mobile wireless communication device when the mobile wireless communication device is within the first range. Methods of using the system are also disclosed.

Abstract: A system for authenticating a mobile computing device is disclosed. The system comprises an access credential module that creates and uses a self-signed access credential. The self-signed access credential indicates that a mobile computing device possessing the access credential is trusted. The system further comprises a data protection module that applies the access credential to data used by the mobile computing device. Methods for using the system are also disclosed.

Abstract: A system for data communication is disclosed. The system comprises a detection module that ascertains when a mobile wireless communication device is located within a first range of a data source. The system further comprises a data module that automatically sends information to the mobile wireless communication device when the mobile wireless communication device is within the first range. Methods of using the system are also disclosed.

Abstract: The present invention provides a method and system for providing a mobile device with a selected subset of global address list (GAL) contacts. The offline GAL contacts stored on the device are in sync with the master corporate GAL. The GAL contacts are automatically selected based on the user's emails or meetings and are not duplicates of the contacts within the user's personal contact list. The GAL contacts are browsed and searched seamlessly with the user's other contacts.