Abstract: Refrigerated hydraulic cement compositions comprise a mixture of (a) ?-tricalcium phosphate powder, (b) monocalcium phosphate comprising monocalcium phosphate anhydrous (MCPA), monocalcium phosphate monohydrate (MCPM), or a combination thereof, wherein a 0.1 g/ml saturated aqueous solution of the monocalcium phosphate has a pH less than 3.0, (c) non-aqueous water-miscible liquid, and (d) an aqueous hydrating liquid. The aqueous hydrating liquid is included in an amount of about 1-50 volume percent, based on the combined volume of the non-aqueous water-miscible liquid and the aqueous hydration liquid, and the refrigerated hydraulic cement composition is storage stable for greater than one day, without setting. Methods of forming hardened cements in vivo and/or for forming implants for use in vivo employ the hydraulic cement compositions.

Abstract: The present invention relates to mosaic implant (15) comprising a plurality of mosaic plates (17) connected by a wire or mesh anchoring arrangement (9). Methods for forming such implants and methods for using said implants for correction of bone and soft tissue defects are described.

Abstract: Non-aqueous hydraulic cement compositions comprise a non-aqueous mixture of a powder composition and a non-aqueous water-miscible liquid. In one embodiment, powder composition is a Brushite or Monetite-forming calcium phosphate powder composition. In another embodiment, the powder composition comprises porous ?-tricalcium phosphate (?-TCP) granules and at least one additional calcium phosphate powder. In another embodiment, the powder composition comprises calcium silicate powder. In a further embodiment, the powder composition comprises calcium aluminate powder. In another embodiment, the powder composition is a cement composition and comprises nanopowders having a grain size of less than 1 micron. Hardened cements are formed from such hydraulic cement compositions, and methods of producing hardened cements, kits, and articles of manufacture employ such hydraulic cement compositions.

Abstract: A hydraulic cement composition comprises a mixture of (a) a cement powder composition which is soluble or partly soluble in water, (b) a non-aqueous water-miscible liquid, and (c) an aqueous hydration liquid. Methods of producing a hardened cement, hardened cements, kits, and articles of manufacture employ such compositions.

Abstract: The present invention relates to mosaic implant (15) comprising a plurality of mosaic plates (17) connected by a wire or mesh anchoring arrangement (9). Methods for forming such implants and methods for using said implants for correction of bone and soft tissue defects are described.

Abstract: Non-aqueous hydraulic cement compositions comprise a non-aqueous mixture of a powder composition and a non-aqueous water-miscible liquid. In one embodiment, powder composition is a Brushite or Monetite-forming calcium phosphate powder composition. In another embodiment, the powder composition comprises porous ?-tricalcium phosphate (?-TCP) granules and at least one additional calcium phosphate powder. In another embodiment, the powder composition comprises calcium silicate powder. In a further embodiment, the powder composition comprises calcium aluminate powder. In another embodiment, the powder composition is a cement composition and comprises nanopowders having a grain size of less than 1 micron. Hardened cements are formed from such hydraulic cement compositions, and methods of producing hardened cements, kits, and articles of manufacture employ such hydraulic cement compositions.