Abstract: An implant for at least partially filling a bore hole in a bone includes a biocompatible plate and a support structure. The support structure has a ring-shaped inner support frame having an outer surface defining the outer diameter of the inner support frame and an inner surface, and an outer support frame having a plurality of fastening points adapted for attaching the implant to bone surrounding a bore hole in which the plate is inserted. The outer support frame is connected to and extends away from the outer surface of the inner support frame. A method of forming the implant is also provided.

Abstract: A bone implant including a wire mesh support frame having a plurality of interconnected wire members and at least two fastening points in the form of retention eyelets connected to the support frame by at least one of the wire members, and a biocompatible plate formed about the support frame, the plate having a bore associated with each of the retention eyelets.

Abstract: An implant for filling a bore hole in a bone includes: a biocompatible plate having upper and lower surfaces; and a support frame having a central portion located at least partially within the plate, an outer rim having a plurality of fastening points adapted for attaching the implant to bone surrounding a bore hole in which the plate is inserted, and a plurality of arms extending between the central portion and the outer rim.

Abstract: A bone implant including a wire mesh support frame (120A) having a plurality of interconnected wire members and at least two fastening points in the form of retention eyelets (140A) connected to the support frame by deformable retention arms (138A), and a biocompatible plate (112) formed about the support frame, the plate having at least two open cavities (116) therein, wherein each of the retention arms extends out of the plate from or into one of the open cavities. A method for correcting a bone defect in a patient, a mesh support frame for use in a bone implant, and a method of fabricating a bone implant are also provided.

Abstract: A mosaic implant (2010) comprises a mesh support frame comprising a plurality of polygonal support rings (2040 A, B, C) connected by a plurality of struts (2014), and a plurality of mosaic plates (2012). The support rings are positioned within the mosaic plates; the struts extend between adjacent plates. An implant (1510) for filling a bore hole comprises a plate (1512) and a support frame (1520) having a central portion (1522) located at least partially within the plate, a polygonal outer rim (1524) having a plurality of fastening points for attaching the implant to bone surrounding a bore hole, and a plurality of arms (1530) extending between the central portion and the outer rim. The plurality of arms extend inwardly and downwardly away from the outer rim such that the central portion is located below the plane of the outer rim and the upper surface of the plate is flush with or slightly above the upper surface of the outer rim.

Abstract: Non-aqueous, hydraulic cement-forming compositions comprise a non-aqueous mixture of (a) a non-hydrated powder composition comprising calcium aluminate powder, and (b) non-aqueous water-miscible liquid. Hardened cements are formed from such hydraulic cement-forming compositions, and methods of producing hardened cements, kits, and articles of manufacture employ such hydraulic cement-forming compositions.

Abstract: A mosaic implant conformable to a curved surface, comprising first and second implant sections coupled along a beam portion extending across a length of the implant, each of the implant sections having—a plurality of biocompatible mosaic plates, and—a plurality of wires which interconnect the plates with one another. The mosaic implant is configured to be deformable such that at least a portion of the mosaic implant is conformable to a curved surface, with the beam portion providing structural support which resists inward deformation of the curved portion of the implant. A kit for forming a mosaic implant is also provided, along with a method for correcting a bone defect in a patient.

Abstract: A calcium phosphate monetite cement-forming composition comprises a monetite-forming calcium-based precursor powder and from 3 to 30 wt %, based on the weight of the precursor powder, of dicalcium pyrophosphate powder. Monetite cements formed form such compositions may be used in implants for correcting bone defects. Methods for bone defect repair employ implants formed from such monetite cements and slow implant resorption and/or improve in vivo bone induction in a patient.

Abstract: Non-aqueous hydraulic cement compositions comprise a non-aqueous mixture of (a) a non-hydrated powder composition comprising calcium silicate powder or calcium aluminate powder, and (b) non-aqueous water-miscible liquid. Hardened cements are formed from such hydraulic cement compositions, and methods of producing hardened cements, kits, and articles of manufacture employ such hydraulic cement compositions.

Abstract: An implant comprises a plurality of discrete biocompatible molded cement mosaic plates of maximum width w and thickness d connected by wire arms molded into and extending substantially laterally from the mosaic plates. Neighbouring mosaic plates are separated by a gap of width t, and at least some of the mosaic plates have a hexagon shape.

Abstract: Refrigerated hydraulic cement compositions comprise a mixture of (a) ?-tricalcium phosphate powder, (b) monocalcium phosphate comprising monocalcium phosphate anhydrous (MCPA), monocalcium phosphate monohydrate (MCPM), or a combination thereof, wherein a 0.1 g/ml saturated aqueous solution of the monocalcium phosphate has a pH less than 3.0, (c) non-aqueous water-miscible liquid, and (d) an aqueous hydrating liquid. The aqueous hydrating liquid is included in an amount of about 1-50 volume percent, based on the combined volume of the non-aqueous water-miscible liquid and the aqueous hydration liquid, and the refrigerated hydraulic cement composition is storage stable for greater than one day, without setting. Methods of forming hardened cements in vivo and/or for forming implants for use in vivo employ the hydraulic cement compositions.

Abstract: Non-aqueous hydraulic cement compositions comprise a non-aqueous mixture of a powder composition and a non-aqueous water-miscible liquid. In one embodiment, powder composition is a Brushite or Monetite-forming calcium phosphate powder composition. In another embodiment, the powder composition comprises porous ?-tricalcium phosphate (?-TCP) granules and at least one additional calcium phosphate powder. In another embodiment, the powder composition comprises calcium silicate powder. In a further embodiment, the powder composition comprises calcium aluminate powder. In another embodiment, the powder composition is a cement composition and comprises nanopowders having a grain size of less than 1 micron. Hardened cements are formed from such hydraulic cement compositions, and methods of producing hardened cements, kits, and articles of manufacture employ such hydraulic cement compositions.

Abstract: A non-aqueous hydraulic cement composition comprises a non-aqueous mixture of (a) ?-tricalcium phosphate powder, (b) monocalcium phosphate powder, and (c) non-aqueous water-miscible liquid, wherein (i) at least about 90% of the monocalcium phosphate powder has a grain size in a range of about 200-600 ?m and the powder (weight) to liquid (volume) ratio is about 2.5-5.5, (ii) at least about 90% of the monocalcium phosphate powder has a grain size in a range of about 1-400 ?m and the powder (weight) to liquid (volume) ratio is about 2-5, or (iii) at least about 90% of the monocalcium phosphate powder has a grain size in a range of about 1-600 ?m and the powder (weight) to liquid (volume) ratio is about 2.5-5.5. Methods, hardened cements, articles of manufacture and kits employ such compositions.