Abstract: Systems and methods for generating synthetic computed tomography (CT) images, such as generating synthetic time-resolved four-dimensional CT or single-photon emission CT images of the human respiratory system, are described. Generating a synthetic CT image includes processing at least one output from a physics-based lung simulation model in combination with at least one generative learning model. The output from the physics-based lung simulation model provides additional information that improves clinical decision-making without additional patient exposure to radiation-intensive imaging procedures.

Abstract: The invention relates to systems and methods for assessing the efficacy of an aerosol for pulmonary drug delivery as well as to an inhaler device, an orally inhaled drug product and a drug/device combination product. An aerosol can be generated by an inhaler device and comprises aerosol particles containing an orally inhaled drug product. The method comprises the steps of providing a computational lung model and a computational particle transport and deposition model, computing a spatial particle deposition distribution of discrete particles based on a determined aerosol value of an aerosol parameter, computing an efficacy value of an efficacy parameter based on the spatial particle deposition distribution and using the efficacy value for automatically assessing the efficacy for pulmonary drug delivery of the aerosol.

Abstract: The invention relates to systems and methods for assessing the efficacy of an aerosol for pulmonary drug delivery as well as to an inhaler device, an orally inhaled drug product and a drug/device combination product. An aerosol can be generated by an inhaler device and comprises aerosol particles containing an orally inhaled drug product. The method comprises the steps of providing a computational lung model and a computational particle transport and deposition model, computing a spatial particle deposition distribution of discrete particles based on a determined aerosol value of an aerosol parameter, computing an efficacy value of an efficacy parameter based on the spatial particle deposition distribution and using the efficacy value for automatically assessing the efficacy for pulmonary drug delivery of the aerosol.

Abstract: The invention relates to systems and methods for assessing the efficacy of an aerosol for pulmonary drug delivery as well as to an inhaler device, an orally inhaled drug product and a drug/device combination product. An aerosol can be generated by an inhaler device and comprises aerosol particles containing an orally inhaled drug product. The method comprises the steps of providing a computational lung model and a computational particle transport and deposition model, computing a spatial particle deposition distribution of discrete particles based on a determined aerosol value of an aerosol parameter, computing an efficacy value of an efficacy parameter based on the spatial particle deposition distribution and using the efficacy value for automatically assessing the efficacy for pulmonary drug delivery of the aerosol.

Abstract: The invention relates to a computer-implemented method, a computer program, a system, and a ventilation machine for determining patient-specific ventilation parameters for setting a ventilation machine by means of which the patient is to be ventilated.