Patents by Inventor Jonas Branalt

Jonas Branalt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES
    Publication number: 20240101549
    Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.
    Type: Application
    Filed: December 16, 2021
    Publication date: March 28, 2024
    Inventors: Jonas BRÅNALT, Björn HOLM, Maria JOHANSSON, Olle KARLSSON, Daniel Laurent KNERR, Anneli NORDQVIST, Robert John SHEPPARD, Marianne SWANSON, Anna TOMBERG
  • N-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)-quinoline-4-carboxamides
    Patent number: 11858924
    Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.
    Type: Grant
    Filed: June 12, 2023
    Date of Patent: January 2, 2024
    Assignee: AstraZeneca
    Inventors: Jonas Brånalt, Maria Johansson, Anneli Nordqvist, Marianne Swanson
  • N-(2-(3-CYANO-2-AZABICYCLO[3.1.0]HEXAN-2-YL)-2-OXOETHYL)QUINOLINE-4-CARBOXAMIDES
    Publication number: 20230406840
    Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein R2, R3, R5, R6, R7, and R8 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.
    Type: Application
    Filed: June 20, 2023
    Publication date: December 21, 2023
    Inventors: Jonas BRÅNALT, Maria JOHANSSON, Anneli NORDQVIST, Gavin O'MAHONY, Marianne SWANSON
  • N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES
    Publication number: 20230312550
    Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.
    Type: Application
    Filed: June 12, 2023
    Publication date: October 5, 2023
    Inventors: Jonas BRÅNALT, Björn HOLM, Maria JOHANSSON, Olle KARLSSON, Daniel Laurent KNERR, Anneli NORDQVIST, Robert John SHEPPARD, Marianne SWANSON, Anna TOMBERG
  • Compounds 148
    Patent number: 8119673
    Abstract: This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containing them and synthetic routes to their production.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: February 21, 2012
    Assignee: AstraZeneca AB
    Inventors: Jonas Brånalt, David Gustafsson, Ingemar Nilsson, Magnus Polla
  • Heterocyclic Carboxamides For Use As Thrombin Inhibitors
    Publication number: 20110130432
    Abstract: This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containing them and synthetic routes to their production.
    Type: Application
    Filed: June 22, 2009
    Publication date: June 2, 2011
    Applicant: ASTRAZENECA AB
    Inventors: Jonas Branalt, David Gustafsson, Ingemar Nilsson, Magnus Polla
  • Novel Compounds 148
    Publication number: 20090318517
    Abstract: This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containing them and synthetic routes to their production.
    Type: Application
    Filed: June 23, 2009
    Publication date: December 24, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Jonas Branalt, David Gustafsson, Ingemar Nilsson, Magnus Polla
  • New Aza-Bicyclohexane Compounds Useful As Inhibitors Of Thrombin
    Publication number: 20090012087
    Abstract: This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containing them and synthetic routes to their production.
    Type: Application
    Filed: July 2, 2008
    Publication date: January 8, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Jonas Branalt, Ingemar Nilsson, Magnus Polla