Abstract: The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating said membrane with an electric current from an array of treatment electrodes; and utilizing a driving force to move said molecule through said perforated membrane.

Abstract: The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating the membrane with an electric current from a treatment electrode; and utilizing a driving force to move the molecule through the perforated membrane.

Abstract: The present invention relates to an exothermic device for topically delivering an active agent comprising a liquid reservoir comprising water, a heating element comprising an oxidizable material, an oxygen-permeable outer-layer, an active agent, and a water-impermeable layer, wherein upon the rupturing of the liquid reservoir, the water contacts the heating element and the oxygen to create and exothermic reaction.

Abstract: The present invention relates to an apparatus for the delivery of an active agent through a body surface of a mammal comprising: (a) a housing with a delivery orifice through the housing; (b) a reservoir within the housing for containing the active where the reservoir is in communication with the delivery orifice; (c) an electrode within the reservoir where the electrode is capable of being in electronic communication with a current supply unit; and (d) a sensor within the reservoir where the sensor is capable of being in electronic communication with the current supply unit; wherein the current supply unit can modify an electric parameter at the electrode based upon feedback from the sensor.

Abstract: Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability

Abstract: The present invention relates to an apparatus for transporting a compound through a barrier membrane of a mammal comprising: (a) a vessel having a membrane contacting surface, said surface having a plurality of exposed blades and a channel adjacent to said blades; (b) a reservoir in communication with said channels for storage of said compound; and (c) an electrode in communication with said reservoir, wherein the width of said blades are tapered away from said surface.

Abstract: The present invention relates to a multi-layer exothermic bandage comprising an oxygen-impermeable layer, a water-impermeable layer, a heating element layer comprising an oxidizable material, and an active agent layer; and the use thereof.

Abstract: Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability.

Abstract: This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.

Abstract: This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.

Abstract: This invention relates to a method for topical treatment of human nail and skin diseases, including fungal infections, bacterial infections, and psoriatic infections. In addition, this invention relates to a method of treating the general condition of human nails including their strength, rate of growth and appearance. More particularly, the invention relates to an acidified composition and methods of using said composition. Still further the invention relates to an acidified lacquer useful in treating human nails and skin.

Abstract: The present invention relates to a two-part container containing an outer container and an inner container for use in containing skin care compositions.

Abstract: A skin care composition comprising an oil-in-water emulsion and a therapeutically effective amount of a retinoid selected from the group consisting of Vitamin A alcohol, Vitamin A aldehyde, retinyl acetate, retinyl palmitate and mixtures thereof, the composition having a pH of between about 4 and about 10 and further comprising an oil phase comprising one or more oils having a total unsaturation density, or C value, of about 1200 or less.

Abstract: There is disclosed a method for the treatment of fungal diseases in nails, which comprises the topical administration to the nail and, if desired, also to the surrounding skin, of (1) a sulfhydryl containing amino acid or a derivative thereof, the pharmaceutically acceptable salts or esters thereof, or stereoisomers thereof, (2) urea, (1) and (2) being administered in an amount sufficient to enhance the permeation of antifungal drugs through nail tissue, either prior to or, preferably, concurrently with the topical administration to the nail of (3) an effective amount of an antifungal drug.

Abstract: Entirely anhydrous topical preparations comprising (I) propylene carbonate, (II) one or more short carbon-chain alcohols and/or glycols including ethanol, isopropyl alcohol, propylene glycol, butylene glycol, polyethylene glycol, hexylene glycol, methoxypolyethylene glycol, and (III) either or both of glycerol and one or more therapeutically or cosmetically active ingredients.

Abstract: Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.

Abstract: This invention relates to compositions and methods for treating the skin containing retinoids and alpha hydroxy acids such as latic acid, malic acid, fruit acids and sugar-cane-derived acids, for mitigating the irratating effects of retinoids on the skin.

Abstract: There is disclosed a method for the treatment of fungal diseases in nails, which comprises the topical administration to the nail and, if desired, also to the surrounding skin, of (1) a sulfhydryl containing amino acid or a derivative thereof, the pharmaceutically acceptable salts or esters thereof, or stereoisomers thereof, (2) urea, (1) and (2) being administered in an amount sufficient to enhance the permeation of antifungal drugs through nail tissue, either prior to or, preferably, concurrently with the topical administration to the nail of (3) an effective amount of an antifungal drug.

Abstract: Skin care compositions comprising a water-in-oil emulsion base containing retinoids and possessing good physical and chemical stability.

Abstract: Skin care compositions comprising a water-in-oil emulsion base containing retinoids and possessing good physical and chemical stability.