Abstract: A system and a method for renal replacement therapy includes a blood treatment unit connected to a blood circuit and a dialysis fluid circuit, the system further including a control unit configured to control the system according to control instructions during a treatment, so as to determine a system parameter value and an indication of membrane fouling of the membrane, and activate an automatic anti-fouling measure that includes a temporary change of the flow rate in the blood circuit and a temporary decrease of the ultrafiltration rate wherein a timing of the temporary change and a timing of the temporary reduction are synchronized.

Abstract: A control system is configured to implement a method of preparing a blood treatment apparatus (1) for blood treatment. The method comprises installing, by use of a disposable arrangement, first and second flow circuits (C1, C2) separated by a semi-permeable membrane (25), the first flow circuit (C1) being connected for fluid communication with the apparatus (1) and the second flow circuit (C2) being connected to form a closed loop that includes a sterilizing filter (46) and, optionally, a container (30). The method further comprises performing backfiltration to transfer a human-compatible fluid from the first flow circuit (C1) to the second flow circuit (C2) through the semi-permeable membrane (25), and circulating (304) the human-compatible fluid in the closed loop of second flow circuit (C2), to thereby sterilize the human-compatible fluid by the sterilizing filter (46) and, optionally, collect a resulting sterile fluid in the container (30) for later use.

Abstract: A renal failure therapy system includes a dialysis fluid circuit including a dialysis fluid pump; a source of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer in operable communication with the dialysis fluid pump, the logic implementer causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source to be added to purified water from the purified water source to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit without a subsequent rinse.

Abstract: A mobile dialysis fluid generation system includes a cargo unit configured to be transported by a vehicle; a cleanroom located inside the cargo unit; water purification equipment; at least one dialysis fluid preparation unit located inside the cleanroom; and at least one area provided outside the cleanroom but inside the cargo unit for storing at least one of a raw material or containers filled with dialysis fluid. The at least one dialysis fluid preparation unit includes at least one concentrate, a mixing device configured to receive purified water from the water purification equipment and to mix the purified water with the at least one concentrate to form dialysis fluid, a tubing set for transfer of the dialysis fluid from the mixing device to a container positioned and arranged to receive the dialysis fluid.

Abstract: A peritoneal dialysis fluid generation system including water purification equipment configured to provide purified water; a presterilized tubing set including a container for storing peritoneal dialysis fluid; at least one glucose or buffer concentrate; and a hemodialysis machine in fluid communication with the water purification equipment. The hemodialysis machine includes at least one mixing pump for mixing the at least one glucose or buffer concentrate with the purified water to form peritoneal dialysis fluid, a dialysis fluid pump for delivering the peritoneal dialysis fluid to the container, and a control unit configured to control the at least one mixing pump to form the peritoneal dialysis fluid and the dialysis fluid pump to deliver the peritoneal dialysis fluid to the container.

Abstract: A medical fluid generation system is disclosed. In an example, a peritoneal dialysis fluid generation system includes water purification equipment configured to provide purified water; a presterilized tubing set including a container for storing peritoneal dialysis fluid; at least one glucose or buffer concentrate; and a hemodialysis machine in fluid communication with the water purification equipment. The hemodialysis machine includes at least one mixing pump for mixing the at least one glucose or buffer concentrate with the purified water to form peritoneal dialysis fluid, a dialysis fluid pump for delivering the peritoneal dialysis fluid to the container, and a control unit configured to control the at least one mixing pump to form the peritoneal dialysis fluid and the dialysis fluid pump to deliver the peritoneal dialysis fluid to the container.

Abstract: A mobile dialysis fluid generation system includes a cargo unit configured to be transported by a vehicle; a cleanroom located inside the cargo unit; water purification equipment; at least one dialysis fluid preparation unit located inside the cleanroom; and at least one area provided outside the cleanroom but inside the cargo unit for storing at least one of a raw material or containers filled with dialysis fluid. The at least one dialysis fluid preparation unit includes at least one concentrate, a mixing device configured to receive purified water from the water purification equipment and to mix the purified water with the at least one concentrate to form dialysis fluid, and a tubing set for transfer of the dialysis fluid from the mixing device to a container positioned and arranged to receive the dialysis fluid.

Abstract: A control system is configured to implement a method of preparing a blood treatment apparatus (1) for blood treatment. The method comprises installing, by use of a disposable arrangement, first and second flow circuits (C1, C2) separated by a semi-permeable membrane (25), the first flow circuit (C1) being connected for fluid communication with the apparatus (1) and the second flow circuit (C2) being connected to form a closed loop that includes a sterilizing filter (46) and, optionally, a container (30). The method further comprises performing backfiltration to transfer a human-compatible fluid from the first flow circuit (C1) to the second flow circuit (C2) through the semi-permeable membrane (25), and circulating (304) the human-compatible fluid in the closed loop of second flow circuit (C2), to thereby sterilize the human-compatible fluid by the sterilizing filter (46) and, optionally, collect a resulting sterile fluid in the container (30) for later use.

Abstract: A renal failure therapy system includes a dialysis fluid circuit including a dialysis fluid pump; a source of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer in operable communication with the dialysis fluid pump, the logic implementer causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source to be added to purified water from the purified water source to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit without a subsequent rinse.

Abstract: A renal failure therapy system (10a, 10b) includes a dialysis fluid circuit (30) including a dialysis fluid pump (54, 58); a source (86, 90) of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source (22) of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer (20) in operable communication with the dialysis fluid pump (54,58), the logic implementer (20) causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source (86, 90) to be added to purified water from the purified water source (22) to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump (54,58) to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit (30) without a subsequent rinse.

Abstract: A system (1) and a method for renal replacement therapy comprising a blood treatment unit (4) connected to a blood circuit (2) and a dialysis fluid circuit (3), the system (1) further comprises a control unit (31) configured to control the system (1) according to control instructions comprising to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane (7), and activate an automatic anti-fouling measure comprising a temporary change of the flow rate in the blood circuit (2) and a temporary decrease of the ultrafiltration rate wherein a timing of the temporary change and a timing of the temporary reduction are synchronized.

Abstract: A renal failure therapy system (10a, 10b) includes a dialysis fluid circuit (30) including a dialysis fluid pump (54, 58); a source (86, 90) of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source (22) of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer (20) in operable communication with the dialysis fluid pump (54,58), the logic implementer (20) causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source (86, 90) to be added to purified water from the purified water source (22) to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump (54,58) to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit (30) without a subsequent rinse.