Abstract: A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated.

Abstract: A set including a first element with a cylindrical shaped part, a second element having a cylindrical shaped groove with a circular opening in an outer surface of the second element, and a mechanical locking device. The mechanical locking device includes a tongue groove, a displacement groove and a flexible tongue in the displacement groove, and is configured to lock the cylindrical shaped part to the cylindrical shaped groove. The flexible tongue is configured to cooperate with the tongue groove for locking the cylindrical shaped part to the cylindrical shaped groove. The flexible tongue is configured to be reshaped and displaced in the displacement groove during locking, and spring back to a locked position. The flexible tongue is configured to exert a spring force on the tongue groove in the locked position.

Abstract: A machine for inserting a tongue in an insertion groove in a panel. An operation of the machine involves displacing a first tongue to an end position of a tongue queue, which includes tongues under compression, in a tongue queue device, compressing the first tongue, displacing the tongues in the tongue queue by compression forces from the tongues under compression, displacing a second tongue, which is at a front position of the tongue queue, to an inserting device, displacing the second tongue into an insertion groove in a panel by the inserting device.

Abstract: A method and device for managing and separating a tongue from a tongue blank, including cutting a first edge of a tongue from the tongue blank by rotating a tool which includes a protruding part, and displacing the tongue by the protruding part to a tongue queue. The method and device may include a second tool for cutting a second edge of the tongue from the tongue blank.

Abstract: The present invention relates to compositions comprising anakinra, buffer, and optionally at least one osmolyte and optionally further excipients. Further, the present invention relates to use of said compositions for treatment of for example ophthalmic disorders.

Abstract: The present invention relates to a syringe having a barrel, a plunger arranged to travel within said barrel and a plunger rod for driving the plunger in a bidirectional manner. The plunger rod is provided with a head at a distal end thereof and a plurality of protruding finger grip enhancing means axially spaced along a length of the plunger rod.

Abstract: A device for inserting a tongue into an insertion groove in a panel including a first part including a supporting surface configured to cooperate with an upper surface of a panel. The device includes a second part, which is connected to the first part, including a guiding device for a displaceable puncher which is configured to displace a tongue into an insertion groove of a panel. The supporting surface is extending in a first direction and the guiding device is extending in second direction.

Abstract: A handheld device is disclosed for inserting a tongue into an insertion groove in a panel. The device includes a first part including a power unit which is configured for driving a puncher. The handheld device includes a second part, which is connected to the first part. The second part includes the displaceable puncher and a guiding device which is configured to guide the displaceable puncher and the tongue. An outer edge of the second part includes a first positioning element and a second positioning element. The first positioning element and the second positioning element are configured to be positioned at least partly in the insertion groove during an insertion of the tongue into the insertion groove. The displaceable puncher is configured to displace the tongue from the handheld device to an inserted position in the insertion groove.

Abstract: A method and device for inserting a tongue in an insertion groove in a panel by a device, wherein the method includes: displacing a tongue guiding device in a first direction by displacing a puncher in the first direction, and displacing a tongue between a first part and a second part of the tongue guiding device and into an insertion groove in panel by further displacing the puncher.

Abstract: A method and device for inserting a tongue in an insertion groove in a panel. The method includes displacing a first tongue to an end position of a tongue queue, which comprises tongues under compression, in a tongue queue device, compressing the first tongue, displacing the tongues in the tongue queue by compression forces from the tongues under compression, displacing a second tongue, which is at a front position of the tongue queue, to an inserting device, displacing the second tongue into an insertion groove in a panel by said inserting device.

Abstract: A method and device for inserting a tongue in an insertion groove in a panel. The method includes displacing a first tongue to an end position of a tongue queue, which comprises tongues under compression, in a tongue queue device, compressing the first tongue, displacing the tongues in the tongue queue by compression forces from the tongues under compression, displacing a second tongue, which is at a front position of the tongue queue, to an inserting device, displacing the second tongue into an insertion groove in a panel by said inserting device.

Abstract: A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the Pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated.

Abstract: A device and a method for attaching a resealable opening device (2) on a package (1), the device comprising an attachment unit (100) having at least one carrier member (101) being movable between a pick-up position and an attachment position, in which latter the carrier member (101) is arranged for attachment of the opening device on the package by means of relative movement between the carrier member and the package. The device further comprises an abutment (113) and a knife arrangement (112), wherein the at least one carrier member, in said pick-up position, is arranged for relative movement towards the abutment for engagement with a web (12) of interconnected opening devices arranged therebetween and for pick-up of one opening device; and wherein the knife arrangement is arranged to cooperate with the carrier member and the abutment or cutting out the opening device during the engagement of the carrier member with the web.

Abstract: A resealable opening device for a flexible package (21) of collapsible type having a compartment defined by flexible walls (24), comprising a thin-walled body (2) having a back surface (3) attachable on one of the flexible walls (24) of the package (21) in a dispensing portion (23) of the package, a first hinge joint (5) extending in a first direction (P1) and connecting a first section (6) of the body (2) with a second section (7) of the body (2), the thin-wall body (2) being intended to be arranged such that the first hinge joint (5) is arranged transversely to a dispensing direction (P4) of the package, and a second hinge joint (8) extending in a second direction (P2) crossing the first hinge joint (5), wherein a locking member (14) is arranged for locking the first section (6) to the second section (7) when the first and second sections (6, 7) are folded towards each other about the first hinge joint (5).

Abstract: A device for inserting a tongue into an insertion groove in a panel including a first part including a supporting surface configured to cooperate with an upper surface of a panel. The device includes a second part, which is connected to the first part, including a guiding device for a displaceable puncher which is configured to displace a tongue into an insertion groove of a panel. The supporting surface is extending in a first direction and the guiding device is extending in second direction.

Abstract: A resealable opening device for a flexible package (21) of collapsible type having a compartment defined by flexible walls (24), comprising a thin-walled body (2) having a back surface (3) attachable on one of the flexible walls (24) of the package (21) in a dispensing portion (23) of the package, a first hinge joint (5) extending in a first direction (P1) and connecting a first section (6) of the body (2) with a second section (7) of the body (2), the thin-wall body (2) being intended to be arranged such that the first hinge joint (5) is arranged transversely to a dispensing direction (P4) of the package, and a second hinge joint (8) extending in a second direction (P2) crossing the first hinge joint (5), wherein a locking member (14) is arranged for locking the first section (6) to the second section (7) when the first and second sections (6, 7) are folded towards each other about the first hinge joint (5).

Abstract: The present invention relates to pharmaceutical compositions comprising anakinra as an active compound in the absence of sodium citrate. The said pharmaceutical compositions are useful for the treatment of IL-1 mediated disorders and for decreasing nociceptive pain during such treatment.

Abstract: A set including a first element with a cylindrical shaped part, a second element having a cylindrical shaped groove with a circular opening in an outer surface of the second element, and a mechanical locking device. The mechanical locking device includes a tongue groove, a displacement groove and a flexible tongue in the displacement groove, and is configured to lock the cylindrical shaped part to the cylindrical shaped groove. The flexible tongue is configured to cooperate with the tongue groove for locking the cylindrical shaped part to the cylindrical shaped groove. The flexible tongue is configured to be reshaped and displaced in the displacement groove during locking, and spring back to a locked position. The flexible tongue is configured to exert a spring force on the tongue groove in the locked position.

Abstract: A handheld device is disclosed for inserting a tongue into an insertion groove in a panel. The device includes a first part including a power unit which is configured for driving a puncher. The handheld device includes a second part, which is connected to the first part. The second part includes the displaceable puncher and a guiding device which is configured to guide the displaceable puncher and the tongue. An outer edge of the second part includes a first positioning element and a second positioning element. The first positioning element and the second positioning element are configured to be positioned at least partly in the insertion groove during an insertion of the tongue into the insertion groove. The displaceable puncher is configured to displace the tongue from the handheld device to an inserted position in the insertion groove.

Abstract: The present invention relates to compositions comprising anakinra, buffer, and optionally at least one osmolyte and optionally further excipients. Further, the present invention relates to use of said compositions for treatment of for example ophthalmic disorders.