Patents by Inventor Jonas Helma-Smets

Jonas Helma-Smets has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
    Publication number: 20250090672
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Application
    Filed: November 26, 2024
    Publication date: March 20, 2025
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
    Patent number: 12171837
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: December 24, 2024
    Assignees: FORSCHUNGSVERBUND BERLIN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • NOVEL ANTI-TPBG ANTIBODY AND ANTIBODY-DRUG-CONJUGATES BASED THEREON, THERAPEUTIC METHODS AND USES THEREOF
    Publication number: 20240245798
    Abstract: The present invention relates to novel anti-TPBG antibody comprising Fc silencing mutations such as leucine (L) to alanine (A) substitution at the position 234 and 235 (LALA mutations), antibody-drug-conjugates (ADCs) based thereon as well as to therapeutic methods and uses thereof, particularly in relation to cancer treatment.
    Type: Application
    Filed: October 18, 2023
    Publication date: July 25, 2024
    Inventors: Jonas Helma-Smets, Annette Vogl, Saskia Schmitt, Isabelle Mai, Sarah Herterich, Dominik Schumacher, Marc-André Kasper, Philipp Cyprys, Marcus Gerlach
  • NOVEL ANTIBODY DRUG CONJUGATES WITH NOVEL NAPI2B ANTIBODIES, THERAPEUTIC METHODS AND USES THEREOF
    Publication number: 20240190958
    Abstract: The present invention relates to novel anti-NaPi2b antibodies, novel antibody-drug-conjugates (ADCs) based thereon as well as to therapeutic methods and uses thereof, particularly in relation to cancer treatment.
    Type: Application
    Filed: October 18, 2023
    Publication date: June 13, 2024
    Inventors: Jonas Helma-Smets, Annette Vogl, Saskia Schmitt, Isabelle Mai, Sarah Herterich, Dominik Schumacher, Marc-André Kasper, Philipp Cyprys, Marcus Gerlach
  • ANTI-NAPI2B ANTIBODIES AND ANTIBODY-DRUG-CONJUGATES BASED THEREON, THERAPEUTIC METHODS AND USES THEREOF
    Publication number: 20240182596
    Abstract: The present invention relates to novel anti-NaPi2b antibodies, antibody-drug-conjugates (ADCs) based thereon as well as to therapeutic methods and uses thereof, particularly in relation to cancer treatment.
    Type: Application
    Filed: October 18, 2023
    Publication date: June 6, 2024
    Inventors: Jonas Helma-Smets, Annette Vogl, Saskia Schmitt, Isabelle Mai, Sarah Herterich, Dominik Schumacher, Marc-André Kasper, Philipp Cyprys, Marcus Gerlach
  • CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
    Publication number: 20230348529
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Application
    Filed: July 10, 2023
    Publication date: November 2, 2023
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
    Patent number: 11746124
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: September 5, 2023
    Assignees: FORSCHUNGSVERBUND BERLIN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • Unusual substrates of tubulin tyrosine ligase
    Patent number: 11572384
    Abstract: The present invention provides means and methods for functionalizing a polypeptide of interest at its C-terminus with an amino acid derivative.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: February 7, 2023
    Assignees: Forschungsverbund Berlin e.V., Ludwig-Mavimilians-Universität München
    Inventors: Christian Hackenberger, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt
  • CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
    Publication number: 20220106356
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof.
    Type: Application
    Filed: August 30, 2021
    Publication date: April 7, 2022
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates
    Patent number: 11161873
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof. A process tor the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: November 2, 2021
    Assignees: FORSCHUNGSVERBUND BERLIN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl
  • CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
    Publication number: 20190330264
    Abstract: Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
    Type: Application
    Filed: September 1, 2017
    Publication date: October 31, 2019
    Inventors: Christian Hackenberger, Marc André Kasper, Maria Glanz, Tom Sauer, Dominik Schumacher, Jonas Helma-Smets, Heinrich Leonhardt, Andreas Stengl