Abstract: The present invention provides single chain T cell engager (TCE) molecules having an scFab that binds a target antigen and an scFv that binds CD3, and TCE molecules that bind CCR8 and CD3. Methods of treating cancer are also provided.

Abstract: The present invention provides anti-CCR8 antibodies and antigen-binding fragments thereof, and methods of making and using said anti-CCR8 antibodies and antigen-binding fragments thereof.

Abstract: The present invention provides bispecific antigen-binding molecules characterized by comprising a first and a second domain, each binding to any of CS1, BCMA, CD20, CD22, FLT3, CD123, CLL1, MSLN, CDH3 or EpCAM, a third domain binding to an extracellular epitope of the human and the Macaca CD3? chain and optionally a fourth domain, which is a Fc modality. Moreover, the invention provides a polynucleotide, encoding the antigen-binding molecule, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Abstract: An anti-squeal shim includes at least a first metal layer and an elastomer layer that is bonded to the first metal layer. The at least first metal layer is configured as a first electrode for electrical connection to a resistance measuring system, and the elastomer layer is configured with structural spatial features that enable the elastomer layer to obtain a reduced thickness when subjected to a mechanical force in a direction perpendicular to the elastomer layer.

Abstract: Sealing caps and method for manufacturing such sealing caps are presented wherein the sealing cap has a body (1) with a U-shaped profile with a base (9) and a perimeter wall (7) wherein the outside of the body is coated with a layer of an elastic material (5) and wherein the base is provided with a continuous convex ridge (12) adjacent the perimeter wall.

Abstract: An anti-squeal shim includes at least a first metal layer and an elastomer layer that is bonded to the first metal layer. The at least first metal layer is configured as a first electrode for electrical connection to a resistance measuring system, and the elastomer layer is configured with structural spatial features that enable the elastomer layer to obtain a reduced thickness when subjected to a mechanical force in a direction perpendicular to the elastomer layer.

Abstract: Sealing caps and method for manufacturing such sealing caps are presented wherein the sealing cap has a body (1) with a U-shaped profile with a base (9) and a perimeter wall (7) wherein the outside of the body is coated with a layer of an elastic material (5) and wherein the base is provided with a continuous convex ridge (12) adjacent the perimeter wall.

Abstract: A dilator may include a substantially conical body having a tip portion at a proximal end and a base portion at a distal end thereof. A wire lock portion may be configured to lock a guide wire to the dilator. A voice prosthesis holding portion may be connected to the substantially conical body by a connecting portion. The holding portion may have a central passage configured to have a tubular body of a voice prosthesis positioned therethrough, wherein at least one flange of the prosthesis is substantially unfolded proximally of the central passage.

Abstract: A dilator assembly for percutaneous dilatational tracheostomy includes a dilator element having a wall and a proximal end part extending into a distal tip part via an intermediate part. The wall has a substantially U-shaped cross section defining a dilator opening. The assembly extends towards the distal tip part. The dilator assembly is part of a tracheostomy device. The device has a first branch for arranging inside the trachea, and a second branch co-operative with the first branch. The first branch has a first end and a receiving member while the opposing second end has a first coupling part. The second branch has a first end with a guide for a neck penetration member and an opposing second end with a second coupling part for coupling with the first coupling part of the first branch. The first and second branches are detachably coupled together at their respective second ends.

Abstract: A dilator may include a substantially conical body having a tip portion at a proximal end and a base portion at a distal end thereof. A wire lock portion may be configured to lock a guide wire to the dilator. A voice prosthesis holding portion may be connected to the substantially conical body by a connecting portion. The holding portion may have a central passage configured to have a tubular body of a voice prosthesis positioned therethrough, wherein at least one flange of the prosthesis is substantially unfolded proximally of the central passage.

Abstract: A dilator may include a substantially conical body having a tip portion at a proximal end and a base portion at a distal end thereof. A wire lock portion may be configured to lock a guide wire to the dilator. A voice prosthesis holding portion may be connected to the substantially conical body by a connecting portion. The holding portion may have a central passage configured to have a tubular body of a voice prosthesis positioned therethrough, wherein at least one flange of the prosthesis is substantially unfolded proximally of the central passage.

Abstract: A device (11) for facilitating tracheotomy. The device comprises a first branch (92), which is adapted to be introduced down the trachea of a patient, such that the end thereof is located below the larynx, and a second branch (114), adapted to be arranged on the outside of the neck with the end thereof located adjacent to the site intended for the tracheostoma. The end of the second branch comprises a guiding tube for a needle, and the end of the first branch comprises a protection plate. When the needle is moved towards the skin through the guiding tube and penetrates the skin and tracheal wall in order to provide said tracheostoma, the needle is directed towards the protection plate, and may engage it after passage through the tracheal wall. In such a manner the other side of the tracheal wall is protected. Furthermore, the tracheostoma will automatically be located at the best position.

Abstract: An improved method and device for securely inserting a tubular element (30) into a through-aperture (40) in a flexible wall (60) accessible from one side only. The tubular element has a retainer (31, 32) projecting transversely at each end thereof, said retainer being resiliently foldable towards the axis of said tubular element. The element is inserted into a loading tube (11), wherein the retainers are automatically folded into the correct orientation by an automatic bending means (18). The bending means is part of a self-contained device for inserting said tubular element (30) into said through-aperture (40).

Abstract: A dilator may include a substantially conical body having a tip portion at a proximal end and a base portion at a distal end thereof. A wire lock portion may be configured to lock a guide wire to the dilator. A voice prosthesis holding portion may be connected to the substantially conical body by a connecting portion. The holding portion may have a central passage configured to have a tubular body of a voice prosthesis positioned therethrough, wherein at least one flange of the prosthesis is substantially unfolded proximally of the central passage.

Abstract: A dilator assembly for percutaneous dilatational tracheostomy includes a dilator element having a wall and a proximal end part extending into a distal tip part via an intermediate part. The wall has a substantially U-shaped cross section defining a dilator opening. The assembly extends towards the distal tip part. The dilator assembly is part of a tracheostomy device. The device has a first branch for arranging inside the trachea, and a second branch co-operative with the first branch. The first branch has a first end and a receiving member while the opposing second end has a first coupling part. The second branch has a first end with a guide for a neck penetration member and an opposing second end with a second coupling part for coupling with the first coupling part of the first branch. The first and second branches are detachably coupled together at their respective second ends.

Abstract: The present invention relates to a device for covering an area, which device comprises an attachment portion and a body. Said body is designed partly spherical made of a flexible material and designed as a cover with a wall essentially extending around the entire cover which has an open end portion. Said wall extends from an end point to said end portion, which end portion is configured to assume a first position with regard to a plane in said end point of said cover and a second position by folding said wall and displacing said end portion past said plane.

Abstract: A device for facilitating tracheotomy includes a first branch (14), which is adapted to be introduced down the trachea of a patient, such that the end thereof is located below the larynx, and a second branch (12), adapted to be arranged on the outside of the neck with the end thereof located adjacent to the site intended for the tracheostoma. The end of the second branch has a guiding tube for a needle, and the end of the first branch has a protection plate. When the needle is moved towards the skin through the guiding tube and penetrates the skin and tracheal wall in order to provide the tracheostoma, the needle is directed towards the protection plate, and may engage it after passage through the tracheal wall. In such a manner the other side of the tracheal wall is protected. Furthermore, the tracheostoma will automatically be located at the best position.

Abstract: The present invention relates to a device for covering an area, which device comprises an attachment portion and a body. Said body is designed partly spherical made of a flexible material and designed as a cover with a wall essentially extending around the entire cover which has an open end portion. Said wall extends from an end point to said end portion, which end portion is configured to assume a first position with regard to a plane in said end point of said cover and a second position by folding said wall and displacing said end portion past said plane.

Abstract: An improved method and device for securely inserting a tubular element (30) into a through-aperture (40) in a flexible wall (60) accessible from one side only. The tubular element has a retainer (31, 32) projecting transversely at each end thereof, said retainer being resiliently foldable towards the axis of said tubular element. The element is inserted into a loading tube (11), wherein the retainers are automatically folded into the correct orientation by an automatic bending means (18). The bending means is part of a self-contained device for inserting said tubular element (30) into said through-aperture (40).

Abstract: A device (11) for facilitating tracheotomy. The device comprises a first branch (92), which is adapted to be introduced down the trachea of a patient, such that the end thereof is located below the larynx, and a second branch (114), adapted to be arranged on the outside of the neck with the end thereof located adjacent to the site intended for the tracheostoma. The end of the second branch comprises a guiding tube for a needle, and the end of the first branch comprises a protection plate. When the needle is moved towards the skin through the guiding tube and penetrates the skin and tracheal wall in order to provide said tracheostoma, the needle is directed towards the protection plate, and may engage it after passage through the tracheal wall. In such a manner the other side of the tracheal wall is protected. Furthermore, the tracheostoma will automatically be located at the best position.