Abstract: This invention provides devices for use in various analytical applications including single-molecule analytical reactions. Methods for detecting analytes optically by propagating optical energy by waveguides within a substrate are provided. Analytical devices are provided which have both shallow and deep waveguides in which illumination light is transported through the deep waveguides and coupled into the shallow waveguides. The shallow waveguides provide evanescent field illumination to analytes, such as single-molecule analytes, within nanometer scale wells. Integrated devices including integrated detectors such as CMOS detectors are included.

Abstract: A method includes displaying a graphical user interface (GUI) for a step sequencer in a digital audio workstation. The GUI includes a sequence of user interface elements corresponding to a portion of a roll for an audio composition. Each user interface element in the sequence of user interface elements represents a respective time interval for a note. The sequence of user interface elements. The method includes receiving a user input interacting with a first user interface element. The method includes, in response to the user input: splitting a played note represented by the first user interface element into two or more played notes. The method further includes providing the audio composition for playback by a speaker.

Abstract: A method includes displaying a graphical user interface (GUI) for a step sequencer in a digital audio workstation. The GUI includes a sequence of user interface elements corresponding to a portion of a roll for an audio composition. Each user interface element in the sequence of user interface elements represents a respective time interval for a note. The sequence of user interface elements. The method includes receiving a user input interacting with a first user interface element. The method includes, in response to the user input: splitting a played note represented by the first user interface element into two or more played notes. The method further includes providing the audio composition for playback by a speaker.