Patents by Inventor Jonas Rosager Henriksen
Jonas Rosager Henriksen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220354789Abstract: The present invention relates to immune stimulating micelle compositions, and their use in treatment of diseases and disorders, such as cancer. In particular, the present invention relates to micelle compositions comprising a TLR7 agonist, such as 1V270.Type: ApplicationFiled: September 18, 2020Publication date: November 10, 2022Inventors: Jonas Rosager Henriksen, Thomas Lars Andresen, Simon Skjøde Jensen, Ladan Parhamifar, Rasmus Dithmar Münter, Anders E. Hansen, Camilla Stavnsbjerg, Esben Christensen
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Publication number: 20220339285Abstract: The present invention relates to a composition comprising non-water soluble dissacharides and oil, a solvent and at least one pharmaceutical ingredient, wherein the composition contains at least two compounds selected from saccharides and lipid oils such as lactose octabenzoate Methyl hepta-O-isobutyryl-?,?-lactoside, ?,?-Lactose octa para-iodobenzoate, 3-iodobenzyl hepta-O-isobutyryl-?,?-lactoside, lactose octapropionate, lactose octaisobutyrate, sucrose octabenzoate, glycerol trihexanoate, Glycerol trioctanoate, Glycerol tridecanoate, Lipiodol, ethyl myristate, ethyl palmitate, ethyl oleoate and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 2,000 centipoise (cP) after administration.Type: ApplicationFiled: June 12, 2020Publication date: October 27, 2022Inventors: Thomas Lars ANDRESEN, Jonas ROSAGER HENRIKSEN, Anders Elias HANSEN, Carl Fredrik MELANDER, Elizabeth SERRANO CHAVEZ, Linda Maria BRUUN
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Patent number: 11173178Abstract: The present invention provides liposomes that are useful for delivery of bioactive agents such as therapeutics. Among others, the liposomes of the invention are capable of delivering their payload at sites of increased secretory phospholipase A2 (sPLA2) activity, because phospholipase A2 (PLA2) will hydrolyse lipids of the liposome. Thus, the liposomes of the invention may e.g. be used in relation to cancer therapy. Another aspect of the invention is a liposomal formulation comprising the liposome of the invention. Still another aspect is a method of producing a liposomal formulation of the invention.Type: GrantFiled: February 10, 2020Date of Patent: November 16, 2021Assignee: LiPlasome Pharma ApSInventors: Anders Falk Vikbjerg, Sune Allan Petersen, Fredrik Melander, Jonas Rosager Henriksen, Kent Jørgensen
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Publication number: 20210275692Abstract: The present disclosure relates to a solution comprising a water insoluble carbohydrate and a fluorescent dye, such as a near infrared (NIR) contrast agent, wherein the solution sets under aqueous conditions, such as in vivo, to form e.g. a gel, a glass, a semi-solid, a solid, a crystal or any mixtures thereof. The disclosure further relates to preparation of such solution and use of such solution for in vivo imaging and/or guidance of surgery or interventional therapeutic procedures.Type: ApplicationFiled: June 19, 2019Publication date: September 9, 2021Inventors: Jonas Rosager HENRIKSEN, Thomas Lars ANDRESEN, Anders Elias HANSEN, Andreas Tue Ingemann JENSEN, Linda Maria BRUUN, Rasmus Irming JØLCK
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Publication number: 20210213010Abstract: The present disclosure relates to a method of loading a toll like receptor (TLR)7/8 agonist into a liposome using remote loading and a kit of parts suitable for the loading of a TLR7/8 agonist into a liposome by said method. The present disclosure further relates to a liposome comprising a salt of a TLR7/8 agonist in the liposome interior and to the use of said liposome for stimulation of an immune response and/or treatment of a clinical condition. Finally, the present disclosure relates to a TLR7/8 agonist which is suitable for being remotely loaded into a liposome.Type: ApplicationFiled: July 24, 2019Publication date: July 15, 2021Inventors: Thomas Lars Andresen, Jonas Rosager Henriksen, Martin Kisha Kraemer, Kira Røpke Jørgensen
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Publication number: 20200171080Abstract: The present invention provides liposomes that are useful for delivery of bioactive agents such as therapeutics. Among others, the liposomes of the invention are capable of delivering their payload at sites of increased secretory phospholipase A2 (sPLA2) activity, because phospholipase A2 (PLA2) will hydrolyse lipids of the liposome. Thus, the liposomes of the invention may e.g. be used in relation to cancer therapy. Another aspect of the invention is a liposomal formulation comprising the liposome of the invention. Still another aspect is a method of producing a liposomal formulation of the invention.Type: ApplicationFiled: February 10, 2020Publication date: June 4, 2020Inventors: Anders Falk VIKBJERG, Sune Allan PETERSEN, Fredrik MELANDER, Jonas Rosager HENRIKSEN, Kent JØRGENSEN
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Publication number: 20200163880Abstract: Disclosed herein are cationic liposomes suitable for specific delivery of immunomodulating agents to monocytes and dendritic cells. The cationic liposomes comprise phospholipids, cholesterol, cationic lipids, PEG and at least one active ingredient and have a zeta potential in the range of 13-25 mV. Further disclosed are uses of such cationic liposomes in various pharmaceutical applications.Type: ApplicationFiled: July 13, 2018Publication date: May 28, 2020Inventors: Thomas Lars ANDRESEN, Simon Skjøde JENSEN, Jonas Rosager HENRIKSEN, Ladan PARHAMIFAR, Rasmus Mikkel Münter LASSEN
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Publication number: 20160158392Abstract: The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides, for example 61Cu and 64Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.Type: ApplicationFiled: December 14, 2015Publication date: June 9, 2016Inventors: Anncatrine Luisa Petersen, Jonas Rosager Henriksen, Palle Hedengran Rasmussen, Andreas Kjær, Thomas Lars Andresen
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Patent number: 9226984Abstract: The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides, for example 61Cu and 64Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.Type: GrantFiled: December 14, 2011Date of Patent: January 5, 2016Assignee: Technical University of Denmark and RigshospitaletInventors: Anncatrine Luisa Petersen, Jonas Rosager Henriksen, Palle Hedengran Rasmussen, Andreas Kjær, Thomas Lars Andresen
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Patent number: 9161993Abstract: The present application discloses a nanoparticle comprising compounds of the formula A-B-C(-D), wherein A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; B designates a cleavable linker; C designates an anionic moiety having a net charge of at least ?2 at pH 6.0; and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue; and wherein the average net charge of the compounds is at least ?1 at pH 6.0. The application also discloses the individual compounds of the formula A-B-C(-D) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal.Type: GrantFiled: May 16, 2012Date of Patent: October 20, 2015Assignee: Danmarks Tekniske UniversitetInventors: Rasmus Irming Jølck, Jonas Rosager Henriksen, Torben Gjetting, Thomas Lars Andresen
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Publication number: 20150202336Abstract: The present invention relates to a novel composition and method for loading delivery systems such as liposome compositions with radionuclides useful in targeted diagnostic and/or therapy of target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The composition and methods of the invention find particular use in diagnosing and imaging cancerous tissue and, in general, pathological conditions associated with leaky blood vessels in a subject. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique. One specific aspect of the invention is directed to a method of producing nanoparticles with desired targeting properties for diagnostic and/or radio-therapeutic applications.Type: ApplicationFiled: December 22, 2014Publication date: July 23, 2015Inventors: Anncatrine Luisa Petersen, Palle Hedengran Rasmussen, Jonas Rosager Henriksen, Andreas Kjaer, Thomas Lars Andresen
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Publication number: 20150079155Abstract: This invention concerns a liposome comprising lipids and at least one active ingredient, wherein at least one of the lipids is a cationic lipid; said liposome exhibiting a net positive charge at physiological conditions at which said liposome preferentially adheres to monocytes in freshly drawn blood when compared to adherence to granulocytes, T-lymphocytes, B-lymphocytes and/or NK cells in freshly drawn blood, to a lipid-based pharmaceutical composition comprising said liposomes and their use in monocytic associated prophylaxis, treatment or amelioration of a condition such as cancer, an infectious disease, an inflammatory disease, an autoimmune disease or allergy.Type: ApplicationFiled: March 14, 2013Publication date: March 19, 2015Inventors: Simon Skjøde Jensen, Thomas Lars Andresen, Jonas Rosager Henriksen, Pia Thermann Johansen
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Patent number: 8920775Abstract: The present invention relates to a novel composition and method for loading delivery systems such as liposome compositions with radionuclides useful in targeted diagnostic and/or therapy of target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The composition and methods of the invention find particular use in diagnosing and imaging cancerous tissue and, in general, pathological conditions associated with leaky blood vessels in a subject. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique. One specific aspect of the invention is directed to a method of producing nanoparticles with desired targeting properties for diagnostic and/or radio-therapeutic applications.Type: GrantFiled: July 16, 2010Date of Patent: December 30, 2014Assignees: Technical University of Denmark, RigshospitaletInventors: Anncatrine Luisa Petersen, Palle Hedengran Rasmussen, Jonas Rosager Henriksen, Andreas Kjær, Thomas Lars Andresen
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Publication number: 20140328897Abstract: The present application discloses a nanoparticle comprising compounds of the formula A-B-C(-D), wherein A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; B designates a cleavable linker; C designates an anionic moiety having a net charge of at least ?2 at pH 6.0; and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue; and wherein the average net charge of the compounds is at least ?1 at pH 6.0. The application also discloses the individual compounds of the formula A-B-C(-D) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal.Type: ApplicationFiled: May 16, 2012Publication date: November 6, 2014Applicant: DANMARKS TEKNISKE UNIVERSITETInventors: Rasmus Irming Jølck, Jonas Rosager Henriksen, Torben Gjetting, Thomas Lars Andresen
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Publication number: 20130251630Abstract: The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides, for example 61Cu and 64Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.Type: ApplicationFiled: December 14, 2011Publication date: September 26, 2013Inventors: Anncatrine Luisa Petersen, Jonas Rosager Henriksen, Palle Hedengran Rasmussen, Andreas Kjær, Thomas Lars Andresen
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Publication number: 20120213698Abstract: The present invention relates to a novel composition and method for loading delivery systems such as liposome compositions with radionuclides useful in targeted diagnostic and/or therapy of target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The composition and methods of the invention find particular use in diagnosing and imaging cancerous tissue and, in general, pathological conditions associated with leaky blood vessels in a subject. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique. One specific aspect of the invention is directed to a method of producing nanoparticles with desired targeting properties for diagnostic and/or radio-therapeutic applications.Type: ApplicationFiled: July 16, 2010Publication date: August 23, 2012Inventors: Anncatrine Luisa Petersen, Palle Hedengran Rasmussen, Jonas Rosager Henriksen, Andreas Kjær, Thomas Lars Andresen
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Publication number: 20120009243Abstract: The present invention provides liposomes that are useful for delivery of bioactive agents such as therapeutics. Among others, the liposomes of the invention are capable of delivering their payload at sites of increased secretory phospholipase A2 (sPLA2) activity, because phospholipase A2 (PLA2) will hydrolyse lipids of the liposome. Thus, the liposomes of the invention may e.g. be used in relation to cancer therapy. Another aspect of the invention is a liposomal formulation comprising the liposome of the invention. Still another aspect is a method of producing a liposomal formulation of the invention.Type: ApplicationFiled: May 25, 2009Publication date: January 12, 2012Applicant: LIPLASOME PHARMA APSInventors: Anders Falk Vikbjerg, Sune Allan Petersen, Fredrik Melander, Jonas Rosager Henriksen, Kent Jørgensen