Abstract: The invention relates to a method for analysis of the AT/GC ratio of DNA by stretching the DNA in nanochannels and performing melting mapping of the AT/GC ratio along the DNA molecule.

Abstract: The invention relates to a method for analysis of the AT/GC ratio of DNA by stretching the DNA in nanochannels and performing melting mapping of the AT/GC ratio along the DNA molecule.

Abstract: The invention relates to a method for analysis of the AT/GC ratio of DNA by stretching the DNA in nanochannels and performing melting mapping of the AT/GC ratio along the DNA molecule.

Abstract: The invention regards a method of manufacturing a structure adapted to be transferred to a non-crystalline layer. The method comprises the steps of providing a substrate having a crystal orientation, providing a plurality of elongate nanostructures (nanowires) on said substrate, said nanostructures extending from the substrate such that the angle defined by the axis of elongation of each nanostructure and the surface normal of the substrate is smaller than 55 degrees, depositing at least one layer of material such that at least the exposed regions of the substrate are covered by said material, removing the substrate such that the deposited layer becomes lowermost layer and exposing at least the extremity of the respective nanostructure of the plurality of nanostructures. Invention also regards a structure manufactured using said method.

Abstract: The invention relates to a nanowire device for manipulation of charged molecules, comprising a tubular nanowire with a through-going channel; a plurality of individually addressable wrap gate electrodes arranged around said tubular nanowire with a spacing between each two adjacent wrap gate electrodes and means for connecting the wrap gate electrodes to a voltage source. The invention further relates to a nanowire system comprising at least one nanowire device, and to a method for manipulating of charged molecules within a through-going channel of a tubular nanowire.

Abstract: The invention relates to a method for analysis of the AT/GC ratio of DNA by stretching the DNA in nanochannels and performing melting mapping of the AT/GC ratio along the DNA molecule.

Abstract: The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.