Patents by Inventor Jonas Uppenberg

Jonas Uppenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds modulating PPAR-gamma
    Publication number: 20030082631
    Abstract: The present invention relates to a method for identifying compounds capable of binding the ligand binding domain of peroxisome proliferator-activated receptor gamma (PPAR&ggr;), and selectively modulating the activity of PPAR&ggr;. The said method includes providing compounds that fit spatially and preferentially into a PPAR&ggr; ligand binding domain having the pharmacophoric features shown in Table I in the patent specification.
    Type: Application
    Filed: July 3, 2002
    Publication date: May 1, 2003
    Inventors: Anna-Lena Gustavsson, Stefan Svensson, Jonas Uppenberg
  • Method of structure-based drug design using a crystalline form of activated trap
    Patent number: 6403330
    Abstract: A crystalline form of mammalian TRAP (tartrate-resistant and purple acid phosphatase) is described. The enzyme is activated by cleavage prior to crystallization with a protease and the crystalline form of the mammalian TRAP is capable of being used for X-ray studies.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: June 11, 2002
    Assignee: Biovitrum AB
    Inventor: Jonas Uppenberg
  • Crystalline form of activated trap and use thereof for structure-based drug design
    Publication number: 20020037283
    Abstract: The invention relates to crystalline form of active TRAP (tartrate-resistant and purple acid phosphatases), preferably human or rat TRAP. The atomic structural coordinates are given as well as the conserved surface which is created by special atoms, relevant for the design of modulators or inhibitors of the human TRAP. This crystalline form of active TRAP can be used for structure-based drug design for specific modulator, activator or inhibitor of TRAP activity, useful in the treatment of diseases or degenerative conditions resulting in increased bone resorption, such as tissue damages, bone metabolic disorders, osteoporosis.
    Type: Application
    Filed: August 2, 2001
    Publication date: March 28, 2002
    Inventor: Jonas Uppenberg
  • Crystalline form of activated tartrate-resistant and purple acid phosphatase
    Patent number: 6329184
    Abstract: A crystalline form of mammalian TRAP (tartrate-resistant and purple acid phosphatase) is described. The enzyme is activated by cleavage prior to crystallization with a protease and the crystalline form of the mammalian TRAP is capable of being used for X-ray studies.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: December 11, 2001
    Assignee: Pharmacia & Upjohn AB
    Inventor: Jonas Uppenberg