Abstract: A method for the safe operation of a machine, which has a movable machine part comprising a hazardous section, comprises: the movable machine part moving according to a predefined sequence program; and an environment of the hazardous section being monitored, wherein, in the event of an engagement of an object into a defined protective volume, which is dependent on the current position of the hazardous section, within the monitored environment, a safety-related reaction is triggered that comprises the movement of the movable machine part being stopped if the engagement exceeds a defined engagement threshold of the protective volume.

Abstract: The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions.

Abstract: The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions.