Abstract: Embodiments of the present invention relate generally to non-invasive methods and tests that measure biomarkers (e.g., tumor antigens) and collect clinical parameters from patients, and computer-implemented machine learning methods, apparatuses, systems, and computer-readable media for assessing a likelihood that a patient has a disease, relative to a patient population or a cohort population. In one embodiment, a classifier is generated using a machine learning system based on training data from retrospective data and subset of inputs (e.g. at least two biomarkers and at least one clinical parameter), wherein each input has an associated weight and the classifier meets a predetermined Receiver Operator Characteristic (ROC) statistic, specifying a sensitivity and a specificity, for correct classification of patients.

Abstract: Nanostructure lipid carriers, delivery systems, methods of making nanostructured lipid carriers and delivery systems, and methods of using the same are disclosed. A composition is disclosed and comprises at least one nanostructured lipid carrier, the nanostructured lipid carrier comprising a shell comprising an emulsifier, and an inner matrix comprising a solid lipid and a liquid lipid, wherein the nanostructured lipid carrier has a diameter of 50 nm or less.

Abstract: A method for calculating a distance between a vehicle camera and an object, the method may include: (a) obtaining an image that was acquired by the vehicle camera of a vehicle; the image captures the horizon, the object, and road lane boundaries; (b) determining an initial row-location horizon estimate and a row-location contact point estimate, the contact point is between the object and a road on which the vehicle is positioned; (c) determining a vehicle camera roll angle correction that once applied will cause the lanes boundaries to be parallel to each other in the real world; (d) calculating a new row-location horizon estimate, wherein the calculating comprises updating the row-location horizon estimate based on the vehicle camera roll angle correction; and (e) calculating the distance between the vehicle camera based on a difference between the new row-location horizon estimate and the row-location contact point estimate.

Abstract: Various catheters are provided herein for recording, mapping, and/or ablating target tissue to reduce or eliminate unwanted electrical impulses. In one embodiment, a catheter can have a handle, an elongate body, and an end effector. The end effector has expanded and contracted configurations and can rotate about the elongate body. A plurality of electrodes can also be disposed on the end effector for recording, mapping, and/or ablating target tissue surrounding the catheter. The handle can guide the end effector through transitioning between the configurations and rotating about the elongate body.

Abstract: Techniques for low-latency packet processing are disclosed. A network device receives a first set of write transactions including a first set of data segments corresponding to a first DMA descriptor from a host. The network device receives a second set of write transactions including a second set of data segments corresponding to a second DMA descriptor from the host. The network device detects that the first set of data segments have been written. In response to detecting that the first set of data segments have been written, and prior to completely writing the second set of data segments and to receiving a packet notifier from the host, the network device processes the first DMA descriptor.

Abstract: A memory apparatus for detecting false hits in a content-addressable memory (CAM) is disclosed. The memory apparatus includes a controller coupled to the CAM and a memory. The controller receives a search result including an address from the CAM, the address corresponding to a matching entry from a first set of data entries that matches a search tag. The controller provides a read address based on the address to the memory, which returns a second data entry from a second set of data entries corresponding to the read address. The controller receives the read data and generates an error detection result based on a comparison between the second data entry and the search tag.

Abstract: Systems, methods, and machine-readable media for predicting interruptions to the use of spare cloud resources and rebalancing based on those predictions are disclosed. A computing platform collects data for customers over time. The computing platform runs a machine learning algorithm on the historical data to generate a prediction classifier. The prediction classifier relates to a time window for prediction into the future, on the order of minutes or hours. The prediction classifier is run on monitored data from ongoing activity with a cloud provider to generate a risk score. Each risk score may identify an amount of risk that a spare cloud resource related to new resource metrics data will be interrupted within the future time frame corresponding to that prediction classifier. If predicted to be interrupted, the customer may be assisted in rebalancing to other resources. As a result, interruptions can be predicted hours into the future.

Abstract: Various catheters are provided herein for recording, mapping, and/or ablating target tissue to reduce or eliminate unwanted electrical impulses. In one embodiment, a catheter can have a handle, an elongate body, and an end effector. The end effector has expanded and contracted configurations and can rotate about the elongate body. A plurality of electrodes can also be disposed on the end effector for recording, mapping, and/or ablating target tissue surrounding the catheter. The handle can guide the end effector through transitioning between the configurations and rotating about the elongate body.

Abstract: Various catheters are provided herein for recording, mapping, and/or ablating target tissue to reduce or eliminate unwanted electrical impulses. In one embodiment, a catheter can have a handle, an elongate body, and an end effector. The end effector has expanded and contracted configurations and can rotate about the elongate body. A plurality of electrodes can also be disposed on the end effector for recording, mapping, and/or ablating target tissue surrounding the catheter. The handle can guide the end effector through transitioning between the configurations and rotating about the elongate body.

Abstract: Various catheters with expandable and contractible fluid pathways extending therethrough, and methods of use, are provided herein. In an exemplary embodiment, a catheter is provided with an elongate body having an electrode at the distal end thereof. One or more expandable members or wings can extend between the electrode and the distal end of the elongate body. The catheter can also include an actuator extending therethrough and coupled to the electrode such that movement of the actuator is effective to advance and retract the electrode, thereby moving the one or more expandable members between a collapsed configuration and an expanded configuration. The catheter can also include a fluid sealed lumen formed therein and configured to receive fluid and to deliver fluid to one or more pathways formed in the electrode. The actuator can extend through the fluid sealed lumen, however it can be fluidly separated from the lumen.

Abstract: The present document describes a process for the preparation of an amino acid supplement formulation and a formulation thereof. The process comprises filtering a clarified whey protein solution with a filter having a molecular weight cut off between about 50 and 300 kDa to obtain a protein solution; dehydrating the protein solution to obtain a powder; and mixing the powder with lecithin. The present document also describes a process for the purification of a whey protein isolate, comprising filtering a clarified whey protein solution with a filter having a molecular weight cut off between about 50 and 300 kDa to obtain a protein solution; and filtering the protein solution with a filter having a molecular weight cut off between about 1 and 100 kDa to obtain a protein solution having at least one of active albumin, beta-lactoglobulin, and alpha-lactalbumin proteins.

Abstract: Embodiments of the present invention relate generally to non-invasive methods and diagnostic tests that measure biomarkers (e.g., tumor antigens), clinical parameters and computer-implemented machine learning methods, apparatuses, systems, and computer-readable media for assessing a likelihood that a patient with radiographic apparent pulmonary nodules are malignant as compared to benign, relative to a patient population or a cohort population. By utilizing algorithms generated from the biomarker levels (e.g., tumor antigens) from large volumes of longitudinal or prospectively collected blood samples (e.g., real world data from one or more regions where blood based tumor biomarker cancer screening is commonplace) together with one or more clinical parameters (e.g. age, smoking history, disease signs or symptoms) a risk level of that patient having malignant pulmonary nodules is provided.

Abstract: Various catheters with expandable and contractible fluid pathways extending therethrough, and methods of use, are provided herein. In an exemplary embodiment, a catheter is provided with an elongate body having an electrode at the distal end thereof. One or more expandable members or wings can extend between the electrode and the distal end of the elongate body. The catheter can also include an actuator extending therethrough and coupled to the electrode such that movement of the actuator is effective to advance and retract the electrode, thereby moving the one or more expandable members between a collapsed configuration and an expanded configuration. The catheter can also include a fluid sealed lumen formed therein and configured to receive fluid and to deliver fluid to one or more pathways formed in the electrode. The actuator can extend through the fluid sealed lumen, however it can be fluidly separated from the lumen.

Abstract: Various catheters are provided herein for recording, mapping, and/or ablating target tissue to reduce or eliminate unwanted electrical impulses. In one embodiment, a catheter can have a handle, an elongate body, and an end effector. The end effector has expanded and contracted configurations and can rotate about the elongate body. A plurality of electrodes can also be disposed on the end effector for recording, mapping, and/or ablating target tissue surrounding the catheter. The handle can guide the end effector through transitioning between the configurations and rotating about the elongate body.

Abstract: Improved ablation procedures and exemplary catheters for use with such procedures are provided. In one example, high quality homogenous lesions with well-defined borders can be created by introducing into a patient body a catheter that includes an electrode that is mounted on a distal end of the catheter, positioning the electrode to be in contact with tissue to be ablated such that at least 65 percent of an exposed distal surface area of the electrode is in contact with the tissue to be ablated, and applying electrical energy to the electrode sufficient to create an ablation lesion in the tissue.

Abstract: Improved mapping and ablation procedures and corresponding devices are provided. A variety of methods and apparatuses can be used for the treatment of cardiac arrhythmias by identifying the location of an arrhythmia source and ablating that source. The methods and apparatuses can provide an improved means of electrical mapping of the heart to identify the location of the arrhythmia source and advancing an ablation electrode to that location so that it may be ablated.

Abstract: An apparatus and a corresponding method. The apparatus includes an injection module operable to maintain packet sequence numbers for a group of network devices, receive a first packet and a second packet that is sent from the apparatus after the first packet and destined for a different device in the group than the first packet, and update the packets with different packet sequence numbers. The packet sequence number for the second packet is generated using the packet sequence number for the first packet. The apparatus further includes an encryption module operable to determine an initialization vector for each packet sequence number and apply an encryption algorithm to each packet. Each packet is encrypted using a corresponding initialization vector and an encryption key as inputs to the encryption algorithm.

Abstract: Various catheters with expandable and contractible fluid pathways extending therethrough, and methods of use, are provided herein. In an exemplary embodiment, a catheter is provided with an elongate body having an electrode at the distal end thereof. One or more expandable members or wings can extend between the electrode and the distal end of the elongate body. The catheter can also include an actuator extending therethrough and coupled to the electrode such that movement of the actuator is effective to advance and retract the electrode, thereby moving the one or more expandable members between a collapsed configuration and an expanded configuration. The catheter can also include a fluid sealed lumen formed therein and configured to receive fluid and to deliver fluid to one or more pathways formed in the electrode. The actuator can extend through the fluid sealed lumen, however it can be fluidly separated from the lumen.

Abstract: A decoder is disclosed that is used to select an area of address space in an Integrated Circuit. The decoder uses a hardware shifting module that performs shift operations on constants. Such a structure reduces an overall area consumption of the shifting module. Additionally, the decoder can perform a multi-bit shift operation in a single clock cycle.

Abstract: Disclosed herein are classifier models, computer implemented systems, machine learning systems and methods thereof for classifying asymptomatic patients into a risk category for having or developing cancer and/or classifying a patient with an increased risk of having or developing cancer into an organ system-based malignancy class membership and/or into a specific cancer class membership.