Patents by Inventor Jonathan A. Covel

Jonathan A. Covel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridine derivatives substituted by heterocyclic ring and amino group
    Patent number: 11771688
    Abstract: Described herein are pyridine derivatives substituted by heterocycle and amino groups and pharmaceutical compositions comprising said compounds. The disclosed compounds are antifungal agents. The subject compounds and compositions are useful for the treatment of fungal diseases and infections.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: October 3, 2023
    Assignee: AMPLYX PHARMACEUTICALS, INC.
    Inventors: Andrei W. Konradi, Jonathan A. Covel, Michael Grey
  • HETEROCYCLE SUBSTITUTED PYRIDINE DERIVATIVE ANTIFUNGAL AGENTS
    Publication number: 20230065881
    Abstract: Described herein are heterocycle substituted pyridine derivative antifungal agents and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of fungal diseases and infections.
    Type: Application
    Filed: September 23, 2022
    Publication date: March 2, 2023
    Applicant: Amplyx Pharmaceuticals, Inc.
    Inventors: Michael Trzoss, Jonathan Covel, Karen Joy Shaw, Peter Webb
  • Heterocycle substituted pyridine derivative antifungal agents
    Patent number: 11512079
    Abstract: Described herein are heterocycle substituted pyridine derivative antifungal agents and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of fungal diseases and infections.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: November 29, 2022
    Assignee: Amplyx Pharmaceuticals, Inc.
    Inventors: Michael Trzoss, Jonathan Covel, Karen Joy Shaw, Peter Webb
  • PYRIDINE DERIVATIVES SUBSTITUTED BY HETEROCYCLIC RING AND AMINO GROUP
    Publication number: 20210275510
    Abstract: Described herein are pyridine derivatives substituted by heterocycle and amino groups and pharmaceutical compositions comprising said compounds. The disclosed compounds are antifungal agents. The subject compounds and compositions are useful for the treatment of fungal diseases and infections.
    Type: Application
    Filed: June 24, 2019
    Publication date: September 9, 2021
    Inventors: Andrei W. KONRADI, Jonathan A. COVEL, Michael GREY
  • HETEROCYCLE SUBSTITUTED PYRIDINE DERIVATIVE ANTIFUNGAL AGENTS
    Publication number: 20210163461
    Abstract: Described herein are heterocycle substituted pyridine derivative antifungal agents and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of fungal diseases and infections.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 3, 2021
    Inventors: Michael TRZOSS, Jonathan COVEL, Karen Joy SHAW, Peter WEBB
  • Antifungal compounds
    Patent number: 11000514
    Abstract: The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: May 11, 2021
    Assignee: Duke University
    Inventors: Jonathan A. Covel, Mitchell Mutz, Peter J. Webb, Robert Remme Webb, II
  • ANTIFUNGAL COMPOUNDS
    Publication number: 20200188364
    Abstract: The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 18, 2020
    Inventors: Jonathan A. Covel, Mitchell Mutz, Peter J. Webb, Robert Remme Webb, II
  • Antifungal compounds
    Patent number: 10568872
    Abstract: The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: February 25, 2020
    Assignee: Duke University
    Inventors: Jonathan A. Covel, Mitchell Mutz, Peter J. Webb, Robert Remme Webb
  • Antifungal Compounds
    Publication number: 20190000814
    Abstract: The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.
    Type: Application
    Filed: May 1, 2018
    Publication date: January 3, 2019
    Applicant: Amplyx Pharmaceuticals, Inc.
    Inventors: Jonathan A. Covel, Mitchell Mutz, Peter J. Webb, Robert Remme Webb
  • Antifungal compounds
    Patent number: 9956207
    Abstract: The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: May 1, 2018
    Assignee: Amplyx Pharmaceuticals, Inc.
    Inventors: Jonathan A. Covel, Mitchell Mutz, Peter J. Webb, Robert Remme Webb, II
  • BRYOSTATIN ANALOGS AND USE THEREOF AS ANTIVIRAL AGENTS
    Publication number: 20170239212
    Abstract: Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including the treatment or prevention of viral infection. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in a low number of steps and with a high degree of substitution and specificity.
    Type: Application
    Filed: August 10, 2015
    Publication date: August 24, 2017
    Inventors: Gary E. KECK, Matthew B. KRAFT, Anh P. TRUONG, Carina C. SANCHEZ, Wei LI, Jonathan A. COVEL, Dennie WELCH, Yam POUDEL, Mark E. PETERSEN
  • Antifungal Compounds
    Publication number: 20160331730
    Abstract: The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.
    Type: Application
    Filed: July 11, 2016
    Publication date: November 17, 2016
    Applicant: Amplyx Pharmaceuticals, Inc.
    Inventors: Jonathan A. Covel, Mitchell Mutz, Peter J. Webb, Robert Remme Webb, II
  • Biphenyl-ethyl-pyrrolidine derivatives as histamine H3 receptor modulators for the treatment of cognitive disorders
    Patent number: 9365511
    Abstract: The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, that modulate the activity of the histamine H3 receptor (Ia). Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: June 14, 2016
    Assignee: ARENA PHARMACEUTICALS, INC.
    Inventors: Jonathan A. Covel, Albert S. Ren, Graeme Semple, Thuy-Anh Tran, Zheng Wei, Yifeng Xiong
  • BIPHENYL-ETHYL-PYRROLIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR MODULATORS FOR THE TREATMENT OF COGNITIVE DISORDERS
    Publication number: 20150353488
    Abstract: The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, that modulate the activity of the histamine H3 receptor (Ia). Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders.
    Type: Application
    Filed: January 8, 2014
    Publication date: December 10, 2015
    Applicant: ARENA PHARMACEUTICALS, INC.
    Inventors: Jonathan A. Covel, Albert S. Ren, Graeme Semple, Thuy-Anh Tran, Zheng Wei, Yifeng Xiong
  • Bryostatin analogues and methods of making and using thereof
    Patent number: 9096550
    Abstract: Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: August 4, 2015
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Gary E Keck, Matthew B Kraft, Anh P Truong, Carina C Sanchez, Wei Li, Jonathan A Covel, Dennie Welch, Yam Poudel
  • BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20110269713
    Abstract: Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.
    Type: Application
    Filed: October 14, 2010
    Publication date: November 3, 2011
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Gary E. Keck, Matthew B. Kraft, Anh P. Truong, Carina C. Sanchez, Wei Li, Jonathan A. Covel, Dennie Welch, Yam Poudel
  • Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof
    Publication number: 20080004263
    Abstract: The present invention relates to compounds Formula I (I) that are modulators of the follicle stimulating hormone (FSH) receptor and are useful in the treatment of infertility and related disorders.
    Type: Application
    Filed: March 3, 2005
    Publication date: January 3, 2008
    Inventors: Vincent Santora, Jonathan Covel, Rena Hayashi, Robert Webb