Patents by Inventor Jonathan A. Eppstein

Jonathan A. Eppstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200023173
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Application
    Filed: April 30, 2019
    Publication date: January 23, 2020
    Inventors: ALAN SMITH, JONATHAN A. EPPSTEIN, BERNADETTE MESSIER, ZORAN NOVAKOVIC, STUART McRAE
  • Patent number: 9579380
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: February 28, 2017
    Assignee: NTT DENKO CORPORATION
    Inventor: Jonathan A. Eppstein
  • Publication number: 20150265823
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Application
    Filed: April 22, 2015
    Publication date: September 24, 2015
    Inventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
  • Patent number: 9033950
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: May 19, 2015
    Assignee: Nitto Denko Corporation
    Inventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
  • Publication number: 20120101426
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Application
    Filed: July 29, 2011
    Publication date: April 26, 2012
    Inventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
  • Patent number: 8016811
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: September 13, 2011
    Assignee: Altea Therapeutics Corporation
    Inventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
  • Publication number: 20110060270
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Application
    Filed: November 12, 2010
    Publication date: March 10, 2011
    Inventor: Jonathan A. Eppstein
  • Publication number: 20100217212
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Application
    Filed: February 24, 2010
    Publication date: August 26, 2010
    Inventor: Jonathan A. Eppstein
  • Patent number: 7758561
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: July 20, 2010
    Assignee: Altea Therapeutics Corporation
    Inventor: Jonathan A. Eppstein
  • Publication number: 20090264810
    Abstract: The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board connected to an energy source for actuating at least one porator; b) a fluid reservoir in fluid communication with the tissue; and c) a tissue interface layer, the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.
    Type: Application
    Filed: January 27, 2009
    Publication date: October 22, 2009
    Inventors: Jonathan A. Eppstein, Stuart McRae
  • Patent number: 7384396
    Abstract: A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: June 10, 2008
    Assignee: SpectRx Inc.
    Inventors: Mark A. Samuels, Jonathan A. Eppstein, Michael R. Hatch, Alan Smith, Mark Faupel
  • Patent number: 7037277
    Abstract: A fluid collection and sensor device for placement over at least one artificial opening made in a biological membrane for measuring a characteristic of a biological fluid collected from the tissue through the at least one artificial opening. The device comprises a sensor positioned in a flow path of the biological fluid for contacting a quantity of the biological fluid and generating an indication of a characteristic of the biological fluid. According to one aspect of the invention, a waste fluid storage element, such as a reservoir, is positioned in the device to collect the biological fluid after it has made contact with the sensor. According to another aspect of the invention, various surfaces of the fluid flow path of the fluid collection and sensor device are treated with an agent to limit or minimize clotting, aggregation or sepsis of the biological fluid, blockage or clogging of the flow path or degradation of the sensor.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: May 2, 2006
    Assignees: SpectRx, Inc., Altea Technologies, Inc.
    Inventors: Alan Smith, Harry K. Delcher, Jonathan A. Eppstein, David Farquhar, Michael R. Hatch, Krishna Kumar
  • Patent number: 6951411
    Abstract: An improved light beam generation and focusing device (15, 50) has a light source (16, 51) constructed and arranged to emit at least one beam of light (20), and a lens assembly (17, 19, 56) constructed and arranged to focus the at least one beam of light on a surface plane. The device is constructed and arranged to sequentially direct the at least one beam of light to at least two spaced locations (21, 21?) on the surface plane. The lens assembly comprises a collimating lens (17), and a spaced focusing lens (19).
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: October 4, 2005
    Assignees: SpectRx, Inc., Altea Technologies, Inc.
    Inventors: Krishna S. Kumar, Danny F. Lincoln, Jonathan A. Eppstein, Michael R. Hatch
  • Patent number: 6922578
    Abstract: An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: July 26, 2005
    Assignees: SpectRx, Inc., Altea Therapeutics Corporation
    Inventors: Jonathan A. Eppstein, Mark A. Samuels, Michael R. Hatch
  • Patent number: 6918874
    Abstract: A system and method for detecting a measuring an analyte in a biological fluid of an animal. A harvesting device (10) is provided suitable for positioning on the surface of tissue of an animal to harvest biological fluid therefrom. The harvesting device (10) comprises an analyte sensor (50) positioned to be contacted by the harvested biological fluid and which generates a measurement signal representative of the analyte. At least one attribute sensor (40) is provided to measure an attribute associated with the biological fluid harvesting operation of the harvesting device (10) or the assay of the biological fluid, and which generates an attribute signal representative of the attribute. Adjustments are made to operational parameters of the harvesting device (10) based on the one or more attributes.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: July 19, 2005
    Assignees: SpectRx, Inc., Altea Technologies, Inc.
    Inventors: Michael R. Hatch, Jonathan A. Eppstein, Stuart McRae
  • Patent number: 6882873
    Abstract: A system and method embodying the invention can be used to detect a characteristic or condition of a patient. A method embodying the invention may include the steps of illuminating a portion of a skin of the patient with light, detecting a frequency spectrum of light scattered from the skin, determining, from first and second portions of the spectrum, a first parameter indicative of a blood content of the skin and a second parameter indicative of a melanin content of the skin, determining, from a third portion of the spectrum, a third parameter indicative of an uncorrected bilirubin concentration, and calculating a corrected bilirubin concentration based on the first, second and third parameters.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: April 19, 2005
    Assignee: Respironics, Inc.
    Inventors: Mark A. Samuels, Keith D. Ignotz, Gregory J. Newman, Jonathan A. Eppstein, Fan Xu
  • Publication number: 20040220456
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Application
    Filed: February 6, 2004
    Publication date: November 4, 2004
    Applicant: Altea Therapeutics Corporation
    Inventor: Jonathan A. Eppstein
  • Publication number: 20040158137
    Abstract: An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive-to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum.
    Type: Application
    Filed: September 25, 2003
    Publication date: August 12, 2004
    Inventors: Jonathan A. Eppstein, Mark A. Samuels, Michael R. Hatch
  • Patent number: 6730028
    Abstract: A method and device for forming artificial openings in a biological membrane with a pyrotechnic charge that is exploded in a controlled manner in proximity of the biological membrane to form the artificial opening(s) therein. The method and device are useful in connection with transdermal delivery and monitoring applications.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: May 4, 2004
    Assignee: Altea Therapeutics Corporation
    Inventors: Jonathan A. Eppstein, Michael R. Hatch, Joseph Papp, Mark L. Faupel, Krishna Kumar
  • Patent number: 6692456
    Abstract: The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment applications, or extracting substances from the animal through the biological membrane for monitoring or other diagnosis applications and for increased transmembrane flux.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: February 17, 2004
    Assignee: Altea Therapeutics Corporation
    Inventors: Jonathan A. Eppstein, Michael R. Hatch, Joseph Papp