Patents by Inventor Jonathan A. Eppstein

Jonathan A. Eppstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9918665
    Abstract: A transdermal permeant delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
    Type: Grant
    Filed: January 3, 2014
    Date of Patent: March 20, 2018
    Assignee: Nitto Denko Corporation
    Inventors: Stuart McRae, Wendy E. Bowerman, Stephen Wilson Braun, Regina Spiehl, Bernadette Messier, David Farquhar, Erin Koch Henkel, Jeremiah Peter O'Leary, Mark James Fisher, Uros Kascak, Loren J. Lantz, Zoran Novakovic, Jonathan Eppstein
  • Patent number: 9579380
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: February 28, 2017
    Assignee: NTT DENKO CORPORATION
    Inventor: Jonathan A. Eppstein
  • Patent number: 9486616
    Abstract: Providing a method for monitoring an analyte extracted from a patient and delivering a permeant composition to the patient. The method includes the steps of a) contacting a poration device to a tissue membrane of the patient, the poration device including at least one porator array; b) actuating poration of the tissue membrane using the at least one porator array in the poration device; c) extracting the analyte from the porated tissue membrane by way of the at least one porator array; d) analyzing the analyte to determine a concentration of the analyte within the tissue membrane; and e) delivering a permeant composition to the tissue membrane by way of the at least one porator array.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: November 8, 2016
    Assignee: NITTO DENKO CORPORATION
    Inventors: Jonathan Eppstein, Stuart McRae
  • Publication number: 20150265823
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Application
    Filed: April 22, 2015
    Publication date: September 24, 2015
    Inventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
  • Patent number: 9033950
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: May 19, 2015
    Assignee: Nitto Denko Corporation
    Inventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
  • Publication number: 20140228736
    Abstract: Providing a method for monitoring an analyte extracted from a patient and delivering a permeant composition to the patient. The method includes the steps of a) contacting a poration device to a tissue membrane of the patient, the poration device including at least one porator array; b) actuating poration of the tissue membrane using the at least one porator array in the poration device; c) extracting the analyte from the porated tissue membrane by way of the at least one porator array; d) analyzing the analyte to determine a concentration of the analyte within the tissue membrane; and e) delivering a permeant composition to the tissue membrane by way of the at least one porator array.
    Type: Application
    Filed: March 5, 2014
    Publication date: August 14, 2014
    Applicant: Nitto Denko Corporation
    Inventors: Jonathan Eppstein, Stuart McRae
  • Patent number: 8706210
    Abstract: The invention provides for a device for delivering a drug comprising: a. forming one or more micropores in a tissue membrane; and b. applying a patch containing a drug to the one or more micropores formed in the tissue membrane The invention also provides for methods of making and methods of using the same.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: April 22, 2014
    Assignee: Nitto Denko Corporation
    Inventors: Jonathan Eppstein, Stuart McRae
  • Patent number: 8641689
    Abstract: A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: February 4, 2014
    Assignee: Nitto Denko Corporation
    Inventors: Bernadette Messier, Zoran Novakovic, Jeremiah Peter O'Leary, Regina Spiehl, Wendy E. Bowerman, Stephen Wilson Braun, Jonathan Eppstein, David Farquhar, Mark James Fisher, Uros Kascak, Erin Koch Henkel, Loren J. Lantz, Stuart McRae
  • Patent number: 8517958
    Abstract: The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board connected to an energy source for actuating at least one porator; b) a fluid reservoir in fluid communication with the tissue; and c) a tissue interface layer, the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: August 27, 2013
    Assignee: Nitto Denko Corporation
    Inventors: Jonathan Eppstein, Stuart McRae
  • Publication number: 20120101426
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Application
    Filed: July 29, 2011
    Publication date: April 26, 2012
    Inventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
  • Patent number: 8116860
    Abstract: A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: February 14, 2012
    Assignee: Altea Therapeutics Corporation
    Inventors: Bernadette Messier, Zoran Novakovic, Jeremiah Peter O'Leary, Regina Spiehl, Wendy E. Bowerman, Stephen Wilson Braun, Jonathan Eppstein, David Farquhar, Mark James Fisher, Uros Kascak, Erin Koch Henkel, Loren J. Lantz, Stuart McRae
  • Publication number: 20120035555
    Abstract: A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
    Type: Application
    Filed: October 13, 2011
    Publication date: February 9, 2012
    Inventors: Bernadette Messier, Zoran Novakovic, Jeremiah Peter O'Leary, Regina Spiehl, Wendy E. Bowerman, Stephen Wilson Braun, Jonathan Eppstein, David Farquhar, Mark James Fisher, Uros Kascak, Erin Koch Henkel, Loren J. Lantz, Stuart McRae
  • Publication number: 20110245728
    Abstract: The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board connected to an energy source for actuating at least one porator; b) a fluid reservoir in fluid communication with the tissue; and c) a tissue interface layer, the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.
    Type: Application
    Filed: November 12, 2010
    Publication date: October 6, 2011
    Inventors: Jonathan Eppstein, Stuart McRae
  • Patent number: 8016811
    Abstract: A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: September 13, 2011
    Assignee: Altea Therapeutics Corporation
    Inventors: Alan Smith, Jonathan A. Eppstein, Bernadette Messier, Zoran Novakovic, Stuart McRae
  • Publication number: 20110060270
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Application
    Filed: November 12, 2010
    Publication date: March 10, 2011
    Inventor: Jonathan A. Eppstein
  • Publication number: 20100217212
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Application
    Filed: February 24, 2010
    Publication date: August 26, 2010
    Inventor: Jonathan A. Eppstein
  • Patent number: 7758561
    Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: July 20, 2010
    Assignee: Altea Therapeutics Corporation
    Inventor: Jonathan A. Eppstein
  • Publication number: 20090264810
    Abstract: The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: a) a controller board connected to an energy source for actuating at least one porator; b) a fluid reservoir in fluid communication with the tissue; and c) a tissue interface layer, the tissue interface layer containing the at least one porator, the porator in contact with the tissue for forming the cavity. The invention also provides for methods of making and methods of using the same.
    Type: Application
    Filed: January 27, 2009
    Publication date: October 22, 2009
    Inventors: Jonathan A. Eppstein, Stuart McRae
  • Patent number: 7392080
    Abstract: The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator comprising: i) an outer body defining a top of the actuator, the outer body containing a cavity; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) the porator array comprising: i) a top surface, with a removable adhesive attached to the top surface, the top surface containing two concentric electrical contact rings for contacting the interface connection port at the anode and the cathode upon removal of the adhesive layer; ii) a bottom surface comprising a tissue interface membrane, the tissue interface membrane further comprising a substrate with at least one porator contained on or within the substrate, the bottom surface further comprising an adhesive layer for a
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: June 24, 2008
    Assignee: Altea Therapeutics Corporation
    Inventors: Jonathan Eppstein, Stuart McRae, Alan Smith
  • Patent number: 7384396
    Abstract: A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: June 10, 2008
    Assignee: SpectRx Inc.
    Inventors: Mark A. Samuels, Jonathan A. Eppstein, Michael R. Hatch, Alan Smith, Mark Faupel