Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.

Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Abstract: The present disclosure provides compositions and methods for the treatment of PPARG activated cancer. For example, the present disclosure provides PPARG signaling modulators for the treatment of bladder cancer. In particular, therapeutic and/or prophylactic compositions and uses of PPARG inverse-agonists are described.

Abstract: An egg sealing unit for an automated biological sample collection system and method of use. The egg sealing unit seals the section of egg from which the shell has been removed. The egg sealing unit includes a sampler, an applicator and an imaging adaptor providing an optical conduit between the surface of an egg and the CAM. The applicator is configured to deliver exogenous material to the CAM, the sampler is configured to collect samples from the CAM and the imaging adaptor allows the CAM to be monitored.

Abstract: An automated biological sample collection system and methods are disclosed. The system comprises an incubator, an applicator and a sampler. The incubator is configured to control the environment of a plurality of eggs, the applicator is configured to deliver exogenous material to the plurality of eggs, at least one sampler is configured to collect samples from the plurality of eggs, invasively or non-invasively and a system controller is operable to drive the various components of the system automatically according to assay specifications and configuration.

Abstract: A solar cell having a fill hole sealed by a spherical plug and at least one curable sealant layer.

Abstract: Solar dye cells having a plastic housing, and methods of construction such solar dye cells.

Abstract: A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.

Abstract: A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.

Abstract: The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Abstract: Accommodating a particular kind of out-of-order data; namely, when data arrives out-of-order because the data is generated in systems that may have different application timelines. As data arrives, it arrives with a particular partition key. For instance, the partition key might identify the source of the data. The data from each partition key is kept in-order with respect to all other data from that same partition key. That said, data from one key is permitted to have a different timeline as compared to data from any other key. Thus, the data may not be in-order when viewed globally across keys. Rather, data is tolerated to be out-of-order globally so long as the lag in the arrived data is within some tolerated lag. If the data arrives having a time that exceeds the maximum tolerated lag, then the system applies some policy to determine what to do with the delayed data.

Abstract: Embodiments include a displacement-generating battery cell for driving a drug-delivery device. The cell includes at least one volume-changing element. The cell also includes a housing formed according to a concertina-shaped design with folds in the walls thereof and containing an internal chemical reaction system. The arrangement of the chemical reaction system is such that as the cell is discharged, the volume-changing element expands, thereby lengthening the battery and thus reducing the extent of said folds, such that the cell becomes taller to reflect the expansion of the volume-changing component.

Abstract: A system and method for predicting or forecasting rare events, such as instances of violent crime within a spatial region, in combination with other correlative variables, such as weather data. One or more machine learning algorithms is employed in order to predict rare events in conjunction with geospatial information and one or more correlative variables. By employing a combination of a downsampling of the rare event data, followed by the application of an ensemble of machine learning algorithms, increased precision of the predictions of future occurrences of the rare events may be achieved.

Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.

Abstract: Methods and processes for brewing malt beverages with electrolytes are provided. In one embodiment of the invention, salts or electrolyte-yielding compounds are added in concentrations or levels greater than those currently believed to be practicable in the art. In some embodiments, the electrolyte-yielding compounds may be added in one or more stages of the brewing process. The methods presented provide flexibility in brewing malt beverages, including beer, with altered electrolyte levels, and alterations of one or more flavors.

Abstract: Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.

Abstract: A complex event processor is described which has a communications interface configured to retrieve event data by pulling it from one or more sources and to receive at least one live event stream pushed to the interface. An event processing pipeline connected to the communications interface comprises a plurality of operator nodes connected between the communications interface and a combiner node which is a node configured to combine event data from the source and from the live event stream. The communications interface is configured to retrieve events from the source and to push the events retrieved from the source along the event processing pipeline towards the combiner node. The communications interface is configured to retrieve and push the retrieved events only in response to request messages passed in an upstream direction from the combiner node to the communications interface along the pipeline.

Abstract: A photovoltaic cell including: (a) a housing including an at least partially transparent cell wall having an interior surface; (b) an electrolyte, disposed within the cell wall, and containing an iodide based species; (c) a transparent electrically conductive coating disposed on the interior surface; (d) an anode disposed on the conductive coating, the anode including: (i) a porous film containing titania, the porous film adapted to make intimate contact with the iodide based species, and (ii) a dye, absorbed on a surface of the porous film, the dye and the porous film adapted to convert photons to electrons; (e) a cathode disposed on an interior surface of the housing, and disposed substantially opposite the anode; (f) electrically-conductive metallic wires, disposed at least partially within the cell, the wires electrically contacting the anode and the electrically conductive coating, and (g) a second electrically conductive coating including an inorganic binder and an inorganic electrically conductive fill

Abstract: A plurality of data items that are annotated with progress markers may be obtained. The progress markers may indicate progress points associated with atemporal processing progress of the respective data items. Deterministic, massively parallel, progressive processing may be initiated on the plurality of data items on a plurality of devices, the progress markers indicating which of the plurality of data items are to be incorporated into results of the progressive processing, the progress markers further indicating an ordering for incorporation of the respective data items into the results.