Abstract: The present invention provides an apparatus for dispensing rolled sheet material, the apparatus including a housing defining an interior adapted to rotatably support rolled sheet material and having a dispensing opening sized to allow sheet material to be dispensed therefrom. The apparatus further includes a nip within the housing such as, for example, may be formed by first and second rollers. In addition, the apparatus includes a sheet material dispensing surface proximate the dispensing opening, the sheet material dispensing surface comprising at least one protrusion.

Abstract: The present invention provides an apparatus for dispensing rolled sheet material, the apparatus including a housing defining an interior adapted to contain rolled sheet material and a dispensing opening for allowing sheet material to be dispensed from the interior of the housing. The apparatus further includes a nip within the housing such as, for example, may be formed by first and second rollers. In addition, the apparatus includes a mobile roll support system adapted to support a roll of sheet material within the housing wherein the roll of sheet material rotates to dispense sheet material and further wherein the mobile roll support system and the roll of sheet material move toward the nip as sheet material is dispensed.

Abstract: A dispenser adapted to dispense sheet material therefrom is provided and includes a housing configured to support a sheet material product therein which has an exit port. The dispenser also includes at least a removable orifice plate for controlling the movement of sheet material from the housing through the exit port. Methods of using and adjusting a dispenser having a removable orifice plate.

Abstract: A method for the treatment of angiogenesis in a patient in need of such treatment, e.g. a tumor patient or a patient suffering from an inflammatory disease, which comprises administering, preferably via an intra-arterial route, an effective amount of a bisphosphonate, e.g. pamidronic acid or zoledronic acid or salts or hydrates thereof, to the patient.

Abstract: An insulation-piercing connector interconnects an insulated conductor and a ribbon conductor embedded in an electrically insulating body. It comprises an insulation-piercing contact formed with a contact body and a tapered contact portion, and a housing device. A hole is made through both the electrically insulating body and ribbon conductor, this hole having a larger-diameter hole section and a smaller-diameter hole section separated by an annular abutment surface formed at least in part by one face of the ribbon conductor. The contact body comprises a larger-diameter body section inserted in the larger-diameter hole section, a smaller-diameter body section inserted in the smaller-diameter hole section, and an annular shoulder surface applied to the annular abutment surface to make contact with the ribbon conductor. The tapered contact portion has a threaded shank screwed in an axial threaded hole of the free end of the smaller-diameter body section to secure the tapered contact portion to the contact body.

Abstract: The invention relates to the use of methanebisphosphonic acid derivatives of formula I for the treatment of fractures. These compounds have surprisingly been found to promote a more rapid and stronger fracture healing in mammals including man.

Abstract: The invention relates to a method of treating the navicular disease in horses, which comprises treating the navicular disease in horses with an effective amount of at least one compound of formula (I), ##STR1## wherein R.sub.1 is hydrogen, hydroxy, amino or halogen, and R.sub.2 is hydrogen, halogen or a radical which is bound through C, N, S or O, or of a C.sub.1 -C.sub.4 tetraalkyl ester thereof, each in the free form or in the form of the salt and/or in the hydrate form; to a compound of formula (I) for use in a method of treating the navicular disease, to a composition for use in a method of treating the navicular disease, which comprises one or more than one compound of formula (I), as well as to the use of a compound of formula (I) for the preparation of a veterinary composition for treating the navicular disease.

Abstract: The invention relates to the use of certain methanebisphosphonic acid derivatives (for the manufacture of a pharmaceutical composition) for the prevention and treatment of prosthesis loosening and prosthesis migration in mammals including man.

Abstract: The invention relates to a novel advantageous oral dosage form for methanediphosphonates, especially the active ingredient disodium pamidronate. A preferred dosage form comprises:a) disodium-3-amino-1-hydroxypropane-1,1-diphosphonate (disodium pamidronate),b) a cationic macroporous ion exchange resin based on a styrene/divinylbenzene copolymer having an exchangeable aminophosphonate group and, where appropriate,c) further pharmaceutically acceptable excipients.The ingredients can be processed to form tablets, dragees, capsules etc.

Abstract: The invention relates to topically administrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives of formula ##STR1## and their salts, wherein R.sub.1 and R.sub.2 are hydrogen or C.sub.1 -C.sub.3 alkyl.

Abstract: The invention relates to topically adminstrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives of formula ##STR1## and their salts, wherein each of R.sub.1 and R.sub.2 is halogen, or wherein R.sub.1 is hydrogen and R.sub.2 is Ar--S-- or Het.sub.1 --NH--, in which Ar is unsubstituted or substituted phenyl and Het.sub.1 is unsubstituted or substituted, monocyclic, 5- or 6-membered monoaza-, diaza- or thiaza-aryl that is bonded via a ring carbon atom, or wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is --A--R.sub.3, in which A is alkylene and, on the one hand, R.sub.3 is Het.sub.2, which is Het.sub.1 bonded via a ring carbon or ring nitrogen atom, or, on the other hand, R.sub.3 is hydrogen, or amino that is unsubsituted or mono- or di-substituted by identical or different substituents selected from alkyl, cycloalkyl, Ar-alkyl, Ar-O-alkyl, Ar-S-alkyl and Het.sub.