Abstract: Use of an ?-lactalbumin enriched whey protein extract as a source of sphingomyelin in a synthetic nutritional composition for an infant or child wherein, the ?-lactalbumin enriched WPE is obtained by a process comprising: a. acidifying a whey protein product to pH 4 or below b. forming a low calcium whey protein product by concentrating the proteins in the acidified whey protein until the calcium to protein ratio is less than about 0.001 and, c. Precipitating ?-lactalbumin from the low-calcium whey protein product, wherein said precipitating step includes the sub-steps of: I. diluting the low-calcium whey protein product, II. adjusting the pH of the diluted low-calcium whey protein product to between 4 and 5 to form a precipitate and soluble proteins, and III. Separating the precipitate proteins from the soluble proteins.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stenoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.

Abstract: A decoder-based irrigation controller comprising a controller housing; a first microcontroller within the controller housing; a decoder interface coupled to the first microcontroller; and a handheld user device, wherein the handheld user device comprises an optical imaging device configured to read an optically readable pattern from each of the plurality of decoder units, wherein the handheld user device is configured to cause data read from the optically readable pattern of the plurality of decoder units to be transferred to the first microcontroller, and wherein the data read comprises an address of each of the plurality of decoder units.

Abstract: The present disclosure is directed to a pre-filled container configured to store a pre-defined volume of a vaporizable liquid composition. The present disclosure is also directed to personal vaporizing devices for using such containers. In one embodiment, the pre-filled container is configured to provide a vaporizable liquid composition stored therein to an ultrasonic vaporizing component via capillary action for vaporization thereof.

Abstract: Computational algorithms integrate and analyze data to consider multiple interdependent, heterogeneous sources and forms of patient data, and using a classification model, provide new learning paradigms, including privileged learning and learning with uncertain clinical data, to determine patient status for conditions such as acute respiratory distress syndrome (ARDS) or non-ARDS.

Abstract: A policy can be consulted to determine an action to take when a disc image is mounted. The action to take can be based on the contents of an application program stored on the disc image. A notification can be received responsive to a user request to mount the disc image. Based on the determined action to take as specified by the policy, the application program can be installed using the privileges of the agent without changing the privileges of an account of a current user.

Abstract: Provided is a chimeric antigen receptor (CAR) or a T cell receptor (TCR) comprising one or more of the antigen binding motifs disclosed herein. Aspects of the disclosure relate to a polynucleotide encoding a chimeric antigen receptor (CAR) or a T cell receptor (TCR) comprising one or more of the antigen binding motifs. Provided are antibodies and antigen binding systems that comprise a binding motif that binds CD20 and optionally a binding motif that binds CD19, and methods of producing and using the same. Antibodies and antigen binding systems of the present disclosure comprise CARs that comprise an anti-CD20 binding motif and an anti-CD19 binding motif. Provided are compositions, such as antibodies and CARs that are or comprise an anti-CD20/anti-CD19 antigen binding system of the present disclosure, and cell therapies comprising the same, are useful, e.g., in the treatment of cancer.

Abstract: The present disclosure provides systems and methods for determining a curve.

Abstract: Methods and systems are provided for a dual-action catheter. In one example, a dual-action catheter system comprises a catheter including a catheter lumen, a bioelectric neuromodulation stylet of a diameter smaller than the lumen of the catheter for insertion of the bioelectric neuromodulation stylet within the catheter lumen, one or more electrodes positioned at a tip end of the bioelectric neuromodulation stylet, and a delivery pathway for delivery of pharmacological treatments therethrough while the bioelectric neuromodulation stylet is inserted within the catheter lumen.

Abstract: A device can receive information that identifies an airspace voxel that represents a three-dimensional portion of airspace during a particular time period. The device can associate one or more airspace parameters with the airspace voxel. The one or more airspace parameters can represent one or more conditions that relate to flight through the airspace voxel during the particular time period. The device can receive one or more flight parameters regarding a potential flight plan of an aircraft through a plurality of airspace voxels, including the airspace voxel, during the particular time period. The device can analyze the one or more flight parameters and a plurality of airspace parameters, associated with the plurality of airspace voxels, using one or more airspace rules. The device can output a recommendation regarding the potential flight plan based on analyzing the one or more flight parameters and the plurality of airspace parameters.

Abstract: A directional illumination apparatus comprises a catadioptric micro-optic array comprising a reflective surface comprising light reflecting facets and an output transmissive surface comprising refractive structures. An array of micro-LEDs is arranged between the reflective surface and output transmissive surface and arranged to illuminate the reflective surface. The light reflecting facets and refractive structures cooperate to provide a uniform output illumination across the output aperture of the array with collimated output. A thin and efficient illumination apparatus may be used for switching display backlighting or environmental illumination applications.

Abstract: A LIDAR system has multiple LIDAR chips that each outputs a LIDAR output signal. External optics receive the LIDAR output signals from the LIDAR chips and operate on the LIDAR output signals such that the LIDAR output signals travel away from the external optics in different directions. A steering device receives the LIDAR output signals from the external optics and operates on the LIDAR output signals such that the LIDAR output signals travel away from the steering device in different directions. The system also includes electronics configured to operate the steering device so as to steer each LIDAR output signal to different sample regions in a field of view.

Abstract: A paintless dent removal tool for knocking down and removing a dent from a vehicle is disclosed. In some embodiments, the paintless dent removal tool includes a threaded bolt having a top end and a bottom end. The paintless dent removal tool further including an arm member having a first end and a second end. The first end of the arm member having a threaded borehole therethrough for detachably securing the threaded bolt in a position transverse to the position of the arm member. The paintless dent removal tool further including a foot member connected to the second end of the arm member. The foot member having a substantially flat lower surface configured to be placed on the outer surface of the vehicle for controlling vibration and improving accuracy when the top end of the bolt is struck by a striking tool.

Abstract: A method for facilitating travel reservations is described. The method may commence with receiving a travel-related query from a user and parsing the travel-related query to derive at least one attribute of the travel-related query. One or more further users may be selected based on comparing the at least one attribute of the user with attributes of the one or more further users. The at least one attribute of the user may be ranked based on preference data of the one or more further users. The method may continue with assigning weights to the at least one attribute based on the ranking to create at least one weighted attribute. Feasible travel itineraries may be searched based on the at least one attribute. The feasible travel itineraries may be scored based on the at least one weighted attribute and travel itineraries selected based on the scoring may be presented.

Abstract: A sheet of polymeric material is made using an extruding process and articles are formed from the sheet of polymeric material. The sheet of polymeric material and the articles comprise one or more polypropylene resins. In some embodiments, the sheet of polymeric material and the articles formed form the sheet of polymeric material are transparent.

Abstract: Methods and systems for monitoring network data packets within a secure network are described. One method includes receiving, at a consumer endpoint, a data packet from a second endpoint, the data packet being encrypted with an encryption key associated with a packet auditing community of interest and having a routing header appended thereto, the routing header identifying the consumer endpoint. The method includes decrypting the data packet using the encryption key associated with the packet auditing community of interest, and removing at least a portion of the routing header identifying the consumer endpoint from the decrypted data packet. The method also includes performing at least one packet auditing operation on the decrypted data packet.

Abstract: A transparent wearable data display having a source of collimated light, a deflector for deflecting the collimated light into a scanned beam, and a first of switchable grating elements sandwiched between first and second parallel transparent substrates, which together functioning as a first light guide. A first coupling is provided for directing the scanned beam into a first total internal reflection (TIR) light path of the first light guide along the first array column. The grating elements having diffracting and non-diffracting states, in their diffracting state deflecting light out of said light guide. The grating elements are switchable into their diffracting states one group of elements at a time.

Abstract: An input/output store instruction is handled. A data processing system includes a system nest coupled to at least one input/output bus by an input/output bus controller. The data processing system further includes at least a data processing unit including a core, system firmware and an asynchronous core-nest interface. The data processing unit is coupled to the system nest via an aggregation buffer. The system nest is configured to asynchronously load from and/or store data to at least one external device which is coupled to the at least one input/output bus. The data processing unit is configured to complete the input/output store instruction before an execution of the input/output store instruction in the system nest is completed. The asynchronous core-nest interface includes an input/output status array with multiple input/output status buffers. The system firmware includes a retry buffer and the core includes an analysis and retry logic.

Abstract: Systems and methods described provide dynamic and intelligent ways to change the required level of user interaction during use of a monitoring device. The systems and methods generally relate to real time switching between a first or initial mode of user interaction and a second or new mode of user interaction. In some cases, the switching will be automatic and transparent to the user, and in other cases user notification may occur. The mode switching generally affects the user's interaction with the device, and not just internal processing. The mode switching may relate to calibration modes, data transmission modes, control modes, or the like.