Patents by Inventor Jonathan Andres Valderrama

Jonathan Andres Valderrama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reducing Antibiotic Resistance in Bacteria Using Pro-Active Genetics
    Publication number: 20230046246
    Abstract: CRISPR-based gene-drive system for inhibiting antibiotic resistance of bacteria, including Escherichia coli that efficiently copies a gRNA cassette and adjacent cargo that are flanked with sequences homologous to the targeted gRNA/Cas9 cleavage site. This “pro-active” genetic system (Pro-AG) functionally inactivates an antibiotic resistance marker on a high copy number plasmid with greater efficiency than control CRISPR-based methods. Pro-AG can effectively edit large plasmids or single-copy genomic targets, or introduce functional genes, with numerous applications to biotechnology and biomedicine.
    Type: Application
    Filed: December 14, 2020
    Publication date: February 16, 2023
    Inventors: Ethan Bier, Victor Nizet, Jonathan Andres Valderrama, Surashree Kulkarni