Patents by Inventor Jonathan Bard

Jonathan Bard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF
    Publication number: 20200276176
    Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 3, 2020
    Inventors: Celia Dominguez, Jonathan Bard, Matthew R. Lee, Longbin Liu, Michael Edward Prime, Samuel Coe
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20200102328
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 2, 2019
    Publication date: April 2, 2020
    Inventors: Celia Dominguez, Samuel Coe, Peter David Johnson, Michael Edward Prime, Christopher John Brown, Sébastien René Gabriel Galan, Paul Richard Giles, Jonathan Bard, Elise Luciennen Paulette Gadouleau, Thomas Martin Krülle, Daniel Clark-Frew, John Wityak, Alex Kiselyov, Sarah Hayes
  • Probes for imaging huntingtin protein
    Patent number: 10479802
    Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: November 19, 2019
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, Samuel Coe, Jonathan Bard, Peter David Johnson, Michael Edward Prime, Christopher John Brown, Sébastien René Gabriel Galan, Paul Richard Giles, Elise Luciennen Paulette Gadouleau, Thomas Martin Krülle, Daniel Clark-Frew, John Wityak, Alex Kiselyov, Sarah Hayes
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20190167821
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: October 26, 2018
    Publication date: June 6, 2019
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Thomas Martin Krulle, Daniel Clark-Frew, Duane Higgins, Matthew Robert Mills, Richard Waldron Marston, Samuel Coe, Samantha Brown, Sarah Hayes
  • Probes for imaging Huntingtin protein
    Patent number: 10137211
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: November 27, 2018
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Thomas Martin Krulle, Daniel Clark-Frew, Duane Higgins, Matthew Robert Mills, Richard Waldron Marston, Samuel Coe, Samantha Brown, Sarah Hayes
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170292150
    Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 12, 2017
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Derek Alexander Weddell, Daryl Simon Walter, Paul Richard Giles, Ian James Wigginton, Malcolm George Taylor, Sébastien René Gabriel Galan, Peter David Johnson, Thomas Martin Krülle, Inaki Morao, Daniel Clark-Frew
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170281804
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 5, 2017
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Thomas Martin Krülle, Daniel Clark-Frew, Sarah Hayes
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170283436
    Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 5, 2017
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Alex Kiselyov, Christopher John Brown, Sébastien René Gabriel Galan, Michael Edward Prime, Paul Richard Giles, Elise Luciennen Paulette Gadouleau, Thomas Martin Krülle, Daniel Clark-Frew, Peter David Johnson, Samuel Coe, Sarah Hayes
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170283439
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 5, 2017
    Applicant: CCHDI Foundation Inc.
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Alex Kiselyov, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Daniel CLark-Frew
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170056535
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 26, 2016
    Publication date: March 2, 2017
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Thomas Martin Krulle, Daniel Clark-Frew, Duane Higgins, Matthew Robert Mills, Richard Waldron Marston, Samuel Coe, Samantha Louise Jones Green, Sarah Hayes
  • Method for identifying agents that interact with beta-site APP cleaving enzyme (BACE)
    Patent number: 7630838
    Abstract: This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: December 8, 2009
    Assignee: American Home Products Corporation
    Inventors: Rajiv Chopra, Kristine Svenson, Bethany Annis Freeman, Tatos N. Akopian, Jonathan Bard, Mark Lloyd Stahl, William S. Somers
  • Beta-amyloid peptide-binding proteins and polynucleotides encoding the same
    Publication number: 20060248605
    Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
    Type: Application
    Filed: July 12, 2006
    Publication date: November 2, 2006
    Applicant: Wyeth
    Inventors: Bradley Ozenberger, Jonathan Bard, Eileen Kajkowski, Jack Jacobsen, Stephen Walker, Heidi Sofia, David Howland
  • Beta-amyloid peptide-binding proteins and polynucleotides encoding the same
    Publication number: 20050282999
    Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
    Type: Application
    Filed: July 16, 2004
    Publication date: December 22, 2005
    Inventors: Bradley Ozenberger, Jonathan Bard, Eileen Kajkowski, Jack Jacobsen, Stephen Walker, Heidi Sofia, David Howland
  • Beta-amyloid peptide-binding proteins and polynucleotides encoding the same
    Publication number: 20050096460
    Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
    Type: Application
    Filed: July 16, 2004
    Publication date: May 5, 2005
    Inventors: Bradley Ozenberger, Jonathan Bard, Eileen Kajkowski, Jack Jacobsen, Stephen Walker, Heidi Sofia, David Howland
  • System and method for optimizing equipment schedules
    Publication number: 20050080660
    Abstract: Embodiments of the invention provide a system and method for developing and optimizing equipment operating schedules. Embodiments also describe the relationship between equipment scheduling and related objectives, such as staff scheduling. In one respect, embodiments of the invention consider staffing constraints in developing equipment schedules. In another respect, embodiments of the invention provide outputs from an equipment scheduling tool that can facilitate improved labor schedules, for example with respect to equipment operators and/or material handlers.
    Type: Application
    Filed: August 31, 2004
    Publication date: April 14, 2005
    Inventors: Anura deSilva, Jonathan Bard, Robert Carignan, Xiangtong Qi, Xinhui Zhang
  • System and method for preference scheduling of staffing resources
    Publication number: 20050004828
    Abstract: The invention provides a system and method for scheduling resources. In one respect, embodiments of the invention allow workers to indicate preferences for specific shifts during a planning horizon, within limitations imposed by the scheduling system. Embodiments of the system and method seek to meet all hard constraints, and utilize a flexible scoring technique to minimize the violation of soft constraints. Embodiments also consider the substitution of higher skilled workers in cases where there is an unmet demand for lower skilled workers.
    Type: Application
    Filed: May 25, 2004
    Publication date: January 6, 2005
    Inventors: Anura deSilva, Jonathan Bard, Robert Carignan, Daniil Yakimovich, Galip Karabulut, Hadi Purnomo, Abhinav Sharma, Sonali Jayawardena, Songul Ozdemir
  • Crystal structure of bace and uses thereof
    Publication number: 20020055459
    Abstract: This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
    Type: Application
    Filed: September 19, 2001
    Publication date: May 9, 2002
    Inventors: Rajiv Chopra, Kristine Svenson, Bethany Annis, Tatos N. Akopian, Jonathan Bard, Mark Lloyd Stahl, William S. Somers